Search Results - "Reuter, Christoph W."

Prognostic role of docetaxel-induced suppression of free testosterone serum levels in metastatic prostate cancer patients by Kappler, Paula, Morgan, Michael A., Ivanyi, Philipp, Brunotte, Stefan J., Ganser, Arnold, Reuter, Christoph W. M.

“…To date, only few data concerning the biologically active, free form of testosterone (FT) are available in metastatic prostate cancer (mPC) and the impact of…”
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Impact of sarcopenia in advanced and metastatic soft tissue sarcoma by Strassmann, Dennis, Hensen, Bennet, Grünwald, Viktor, Stange, Katharina, Eggers, Hendrik, Länger, Florian, Omar, Mohamed, Zardo, Patrick, Christiansen, Hans, Reuter, Christoph W., Wacker, Frank K., Ganser, Arnold, Ivanyi, Philipp

“…Introduction Advanced or metastatic soft tissue sarcoma (a/mSTS) is associated with a dismal prognosis. Patient counseling on treatment aggressiveness is…”
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Modulation of anthracycline-induced cytotoxicity by targeting the prenylated proteome in myeloid leukemia cells by Morgan, Michael A., Onono, Fredrick O., Spielmann, H. Peter, Subramanian, Thangaiah, Scherr, Michaela, Venturini, Letizia, Dallmann, Iris, Ganser, Arnold, Reuter, Christoph W. M.

“…Deregulation of Ras/ERK signaling in myeloid leukemias makes this pathway an interesting target for drug development. Myeloid leukemia cell lines were screened…”
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Carboplatin plus weekly docetaxel as salvage chemotherapy in docetaxel-resistant and castration-resistant prostate cancer by Reuter, Christoph W. M., Morgan, Michael A., Ivanyi, Philipp, Fenner, Martin, Ganser, Arnold, Grünwald, Viktor

“…Background There is no proven, effective, standard second-line chemotherapy for castration- and docetaxel-resistant prostate cancer (DRPC). Recent data suggest…”
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NADH dehydrogenase subunit 4 variant sequences in childhood acute myeloid leukaemia by Morgan, Michael A., Markus, Birgit, Hermkens, Malou, Damm, Frederik, Reinhardt, Dirk, Zimmermann, Martin, Thol, Felicitas, Bunke, Tania, Bogoeva, Dessislava, Reuter, Christoph W. M., Haas, Valerie, Heuvel‐Eibrink, Marry M., Zwaan, Christian M., Reinhardt, Katarina

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Lack of noncanonical RAS mutations in cytogenetically normal acute myeloid leukemia by Reuter, Christoph W. M., Krauter, Jürgen, Onono, Fredrick O., Bunke, Tania, Damm, Frederik, Thol, Felicitas, Wagner, Katharina, Göhring, Gudrun, Schlegelberger, Brigitte, Heuser, Michael, Ganser, Arnold, Morgan, Michael A.

“…Transforming mutations in RAS genes are commonly found in human malignancies, including myeloid leukemias. To investigate the incidence, spectrum, and…”
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Combining prenylation inhibitors causes synergistic cytotoxicity, apoptosis and disruption of RAS‐to‐MAP kinase signalling in multiple myeloma cells by Morgan, Michael A., Sebil, Tarkan, Aydilek, Erdem, Peest, Dietrich, Ganser, Arnold, Reuter, Christoph W. M.

“…Summary The high incidence of activating RAS mutations, coupled with accumulating evidence linking RAS to multiple myeloma (MM) pathogenesis, indicate that…”
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Molecularly targeted therapies in myelodysplastic syndromes and acute myeloid leukemias by Morgan, Michael A, Reuter, Christoph W M

“…Although there has been significant progress in acute myeloid leukemia (AML) treatment in younger adults during the last decade, standard induction therapy…”
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Cell-cycle–dependent activation of mitogen-activated protein kinase kinase (MEK-1/2) in myeloid leukemia cell lines and induction of growth inhibition and apoptosis by inhibitors of RAS signaling by Morgan, Michael A., Dolp, Oliver, Reuter, Christoph W.M.

“…Disruption of the RAS–to–mitogen-activated protein kinase (MAPK/ERK) signaling pathway, either directly through activatingRAS gene mutations or indirectly…”
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Targeting vascular endothelial growth factor (VEGF)-receptor-signaling in renal cell carcinoma by REUTER, Christoph W. M, MORGAN, Michael A, GRÜNWALD, Viktor, HERRMANN, Thomas R. W, BURCHARDT, Martin, GANSER, Arnold

“…Metastatic renal cell carcinoma (RCC) is resistant to conventional chemotherapy. Combined data for a variety of immunotherapies resulted in an overall chance…”
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A Tagging-via-substrate Approach to Detect the Farnesylated Proteome Using Two-dimensional Electrophoresis Coupled with Western Blotting by Onono, Fredrick O., Morgan, Michael A., Spielmann, H. Peter, Andres, Douglas A., Subramanian, Thangaiah, Ganser, Arnold, Reuter, Christoph W.M.

“…Prenylation is a post-translational modification critical for the proper function of multiple physiologically important proteins, including small G-proteins,…”
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Prognostic role of docetaxel-induced reduction of free testosterone serum levels in metastatic prostate cancer patients by Kappler, Paula, Brunotte, Stefan, Ivanyi, Philipp, Morgan, Michael A., Reuter, Christoph W.

“…Abstract only 144 Background: We have recently demonstrated that a salvage therapy with carboplatin plus weekly docetaxel is effective in docetaxel-refractory…”
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Role of free testosterone serum levels during salvage chemotherapy with carboplatin plus weekly docetaxel in patients with docetaxel-refractory, metastatic castration-resistant prostate cancer (mCRPC) by Brunotte, Stefan, Ivanyi, Philipp, Kappler, Paula, Morgan, Michael A., Reuter, Christoph W.

“…Abstract only 145 Background: Carboplatin plus docetaxel (CD) may be effective in mDRPC. Platinum(II)-complexes interfere with steroid biosynthesis and thus…”
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Survival in metastatic renal cell carcinoma (mRCC) patients over two decades: Does age mater? by Eggers, Hendik, Schuenemann, Christoph, Grünwald, Viktor, Rudolph, Linda, Tiemann, Maria-Luisa, Reuter, Christoph W., Ganser, Arnold, Ivanyi, Philipp

“…Abstract only e17103 Background: Although the therapeutic landscape changed dramatically in the recent past, little is known about the outcome of elderly mRCC…”
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Prognostic value of testosterone levels during chemotherapy with carboplatin plus weekly docetaxel in metastatic castration- and docetaxel-resistant prostate cancer (mDRPC) by Reuter, Christoph W., Ivanyi, Philipp, Grünwald, Viktor, von Klot, Christoph AJ, Morgan, Michael A., Brunotte, Stefan

“…Abstract only…”
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Sarcopenia (SMI(+)) in patients (pts) with advanced or metastatic soft tissue sarcoma (a/mSTS): Potential parameter for risk prediction during multimodal therapy (MT)? by Strassmann, Dennis, Hensen, Bennet, Gruenwald, Viktor, Stange, Katharina, Eggers, Hendik, Länger, Florain, Panzica, Martin, Zardo, Patrick, Christiansen, Hans, Reuter, Christoph W., Wacker, Frank, Ganser, Arnold, Ivanyi, Philipp

“…Abstract only 11069 Background: Objective parameters identifying ideal pts for MT from pts with a/mSTS remain scarce. Here, we analysed the impact of…”
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Association of multimodality treatment (MT) with improved overall survival (OS) in patients (pts) with advanced/metastastic soft tissue sarcoma (a/m STS) by Ivanyi, Philipp, Stange, Katharina, Eggers, Hendik, Reuter, Christoph W., Panzica, Martin, Zardo, Patrick, Länger, Florain, Christiansen, Hans, Ganser, Arnold, Grünwald, Viktor

“…Abstract only…”
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Prognostic significance of free testosterone levels during chemotherapy with carboplatin plus docetaxel (CD) in metastatic castration- and docetaxel-resistant prostate cancer (mDRPC) by Reuter, Christoph W., Ivanyi, Philipp, von Klot, Christoph A. J., Merseburger, Axel Stuart, Grünwald, Viktor, Ganser, Arnold

“…Abstract only…”
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Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematologic malignancies? by Reuter, Christoph W. M., Morgan, Michael A., Bergmann, Lothar

“…A series of alterations in the cellular genome affecting the expression or function of genes controlling cell growth and differentiation is considered to be…”
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Late onset of bone metastases as a prognostic parameter in metastatic renal cell cancer (mRCC): A single-center experience in 82 mRCC patients treated with sunitinib by Ivanyi, Philipp, Koenig, Jasper, Trummer, Arne, Reuter, Christoph W., Ganser, Arnold, Grünwald, Viktor

“…Abstract only 523 Background: Bone metastasis (BM) is considered a negative prognostic marker in metastatic renal cell carcinoma (mRCC). Here, we address the…”
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