Search Results - "Reuss, David E"

Updates on the WHO diagnosis of IDH-mutant glioma by Reuss, David.E.

“…Purpose The WHO classification of Tumors of the Central Nervous System represents the international standard classification for brain tumors. In 2021 the 5th…”
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Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience by Capper, David, Stichel, Damian, Sahm, Felix, Jones, David T. W., Schrimpf, Daniel, Sill, Martin, Schmid, Simone, Hovestadt, Volker, Reuss, David E., Koelsche, Christian, Reinhardt, Annekathrin, Wefers, Annika K., Huang, Kristin, Sievers, Philipp, Ebrahimi, Azadeh, Schöler, Anne, Teichmann, Daniel, Koch, Arend, Hänggi, Daniel, Unterberg, Andreas, Platten, Michael, Wick, Wolfgang, Witt, Olaf, Milde, Till, Korshunov, Andrey, Pfister, Stefan M., von Deimling, Andreas

“…Recently, we described a machine learning approach for classification of central nervous system tumors based on the analysis of genome-wide DNA methylation…”
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IDH mutant diffuse and anaplastic astrocytomas have similar age at presentation and little difference in survival: a grading problem for WHO by Reuss, David E., Mamatjan, Yasin, Schrimpf, Daniel, Capper, David, Hovestadt, Volker, Kratz, Annekathrin, Sahm, Felix, Koelsche, Christian, Korshunov, Andrey, Olar, Adriana, Hartmann, Christian, Reijneveld, Jaap C., Wesseling, Pieter, Unterberg, Andreas, Platten, Michael, Wick, Wolfgang, Herold-Mende, Christel, Aldape, Kenneth, von Deimling, Andreas

“…The WHO 2007 classification of tumors of the CNS distinguishes between diffuse astrocytoma WHO grade II (A II WHO2007 ) and anaplastic astrocytoma WHO grade…”
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A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR by Sievers, Philipp, Sill, Martin, Schrimpf, Daniel, Stichel, Damian, Reuss, David E, Sturm, Dominik, Hench, Jürgen, Frank, Stephan, Krskova, Lenka, Vicha, Ales, Zapotocky, Michal, Bison, Brigitte, Castel, David, Grill, Jacques, Debily, Marie-Anne, Harter, Patrick N, Snuderl, Matija, Kramm, Christof M, Reifenberger, Guido, Korshunov, Andrey, Jabado, Nada, Wesseling, Pieter, Wick, Wolfgang, Solomon, David A, Perry, Arie, Jacques, Thomas S, Jones, Chris, Witt, Olaf, Pfister, Stefan M, von Deimling, Andreas, Jones, David T W, Sahm, Felix

“…Abstract Background Malignant astrocytic gliomas in children show a remarkable biological and clinical diversity. Small in-frame insertions or missense…”
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Morphologic and immunohistochemical features of malignant peripheral nerve sheath tumors and cellular schwannomas by Pekmezci, Melike, Reuss, David E, Hirbe, Angela C, Dahiya, Sonika, Gutmann, David H, von Deimling, Andreas, Horvai, Andrew E, Perry, Arie

“…Cellular schwannoma is an uncommon, but well-recognized, benign peripheral nerve sheath tumor, which can be misdiagnosed as malignant peripheral nerve sheath…”
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Methylation-based classification of benign and malignant peripheral nerve sheath tumors by Röhrich, Manuel, Koelsche, Christian, Schrimpf, Daniel, Capper, David, Sahm, Felix, Kratz, Annekathrin, Reuss, Jana, Hovestadt, Volker, Jones, David T. W., Bewerunge-Hudler, Melanie, Becker, Albert, Weis, Joachim, Mawrin, Christian, Mittelbronn, Michel, Perry, Arie, Mautner, Victor-Felix, Mechtersheimer, Gunhild, Hartmann, Christian, Okuducu, Ali Fuat, Arp, Mirko, Seiz-Rosenhagen, Marcel, Hänggi, Daniel, Heim, Stefanie, Paulus, Werner, Schittenhelm, Jens, Ahmadi, Rezvan, Herold-Mende, Christel, Unterberg, Andreas, Pfister, Stefan M., von Deimling, Andreas, Reuss, David E.

“…The vast majority of peripheral nerve sheath tumors derive from the Schwann cell lineage and comprise diverse histological entities ranging from benign…”
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Infratentorial IDH-mutant astrocytoma is a distinct subtype by Banan, Rouzbeh, Stichel, Damian, Bleck, Anja, Hong, Bujung, Lehmann, Ulrich, Suwala, Abigail, Reinhardt, Annekathrin, Schrimpf, Daniel, Buslei, Rolf, Stadelmann, Christine, Ehlert, Karoline, Prinz, Marco, Acker, Till, Schittenhelm, Jens, Kaul, David, Schweizer, Leonille, Capper, David, Harter, Patrick N., Etminan, Nima, Jones, David T. W., Pfister, Stefan M., Herold-Mende, Christel, Wick, Wolfgang, Sahm, Felix, von Deimling, Andreas, Hartmann, Christian, Reuss, David E.

“…Diffuse IDH-mutant astrocytic tumors are rarely diagnosed in the cerebellum or brainstem. In this multi-institutional study, we characterized a series of…”
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Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience by Pfaff, Elke, El Damaty, Ahmed, Balasubramanian, Gnana Prakash, Blattner-Johnson, Mirjam, Worst, Barbara C., Stark, Sebastian, Witt, Hendrik, Pajtler, Kristian W., van Tilburg, Cornelis M., Witt, Ruth, Milde, Till, Jakobs, Martin, Fiesel, Petra, Frühwald, Michael C., Hernáiz Driever, Pablo, Thomale, Ulrich W., Schuhmann, Martin U., Metzler, Markus, Bochennek, Konrad, Simon, Thorsten, Dürken, Matthias, Karremann, Michael, Knirsch, Stephanie, Ebinger, Martin, von Bueren, André O., Pietsch, Torsten, Herold-Mende, Christel, Reuss, David E., Kiening, Karl, Lichter, Peter, Eggert, Angelika, Kramm, Christof M., Pfister, Stefan M., Jones, David T.W., Bächli, Heidi, Witt, Olaf

“…Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive paediatric brain tumour with fatal outcome. The Individualised Therapy For Relapsed Malignancies…”
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Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations by Reuss, David E., Piro, Rosario M., Jones, David T. W., Simon, Matthias, Ketter, Ralf, Kool, Marcel, Becker, Albert, Sahm, Felix, Pusch, Stefan, Meyer, Jochen, Hagenlocher, Christian, Schweizer, Leonille, Capper, David, Kickingereder, Phillipp, Mucha, Jana, Koelsche, Christian, Jäger, Natalie, Santarius, Thomas, Tarpey, Patrick S., Stephens, Philip J., Andrew Futreal, P., Wellenreuther, Ruth, Kraus, Jürgen, Lenartz, Doris, Herold-Mende, Christel, Hartmann, Christian, Mawrin, Christian, Giese, Nathalia, Eils, Roland, Collins, V. Peter, König, Rainer, Wiestler, Otmar D., Pfister, Stefan M., von Deimling, Andreas

“…Meningiomas are among the most frequent intracranial tumors. The secretory variant of meningioma is characterized by glandular differentiation, formation of…”
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Routine RNA sequencing of formalin-fixed paraffin-embedded specimens in neuropathology diagnostics identifies diagnostically and therapeutically relevant gene fusions by Stichel, Damian, Schrimpf, Daniel, Casalini, Belén, Meyer, Jochen, Wefers, Annika K., Sievers, Philipp, Korshunov, Andrey, Koelsche, Christian, Reuss, David E., Reinhardt, Annekathrin, Ebrahimi, Azadeh, Fernández-Klett, Francisco, Kessler, Tobias, Sturm, Dominik, Ecker, Jonas, Milde, Till, Herold-Mende, Christel, Witt, Olaf, Pfister, Stefan M., Wick, Wolfgang, Jones, David T. W., von Deimling, Andreas, Sahm, Felix

“…Molecular markers have become pivotal in brain tumor diagnostics. Mutational analyses by targeted next-generation sequencing of DNA and array-based DNA…”
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Quercetin promotes degradation of survivin and thereby enhances death-receptor-mediated apoptosis in glioma cells by Siegelin, Markus D, Reuss, David E, Habel, Antje, Rami, Abdelhaq, von Deimling, Andreas

“…The flavonoid quercetin has been reported to inhibit the proliferation of cancer cells, whereas it has no effect on nonneoplastic cells. U87-MG, U251, A172,…”
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Tumors diagnosed as cerebellar glioblastoma comprise distinct molecular entities by Reinhardt, Annekathrin, Stichel, Damian, Schrimpf, Daniel, Koelsche, Christian, Wefers, Annika K, Ebrahimi, Azadeh, Sievers, Philipp, Huang, Kristin, Casalini, M Belén, Fernández-Klett, Francisco, Suwala, Abigail, Weller, Michael, Gramatzki, Dorothee, Felsberg, Joerg, Reifenberger, Guido, Becker, Albert, Hans, Volkmar H, Prinz, Marco, Staszewski, Ori, Acker, Till, Dohmen, Hildegard, Hartmann, Christian, Paulus, Werner, Heß, Katharina, Brokinkel, Benjamin, Schittenhelm, Jens, Buslei, Rolf, Deckert, Martina, Mawrin, Christian, Hewer, Ekkehard, Pohl, Ute, Jaunmuktane, Zane, Brandner, Sebastian, Unterberg, Andreas, Hänggi, Daniel, Platten, Michael, Pfister, Stefan M, Wick, Wolfgang, Herold-Mende, Christel, Korshunov, Andrey, Reuss, David E, Sahm, Felix, Jones, David T W, Capper, David, von Deimling, Andreas

“…In this multi-institutional study we compiled a retrospective cohort of 86 posterior fossa tumors having received the diagnosis of cerebellar glioblastoma…”
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Pleomorphic xanthoastrocytoma is a heterogeneous entity with pTERT mutations prognosticating shorter survival by Ebrahimi, Azadeh, Korshunov, Andrey, Reifenberger, Guido, Capper, David, Felsberg, Joerg, Trisolini, Elena, Pollo, Bianca, Calatozzolo, Chiara, Prinz, Marco, Staszewski, Ori, Schweizer, Leonille, Schittenhelm, Jens, Harter, Patrick N, Paulus, Werner, Thomas, Christian, Kohlhof-Meinecke, Patricia, Seiz-Rosenhagen, Marcel, Milde, Till, Casalini, Belén M, Suwala, Abigail, Wefers, Annika K, Reinhardt, Annekathrin, Sievers, Philipp, Kramm, Christof M, Etminam, Nima, Unterberg, Andreas, Wick, Wolfgang, Herold-Mende, Christel, Sturm, Dominik, Pfister, Stefan M, Sill, Martin, Jones, David T W, Schrimpf, Daniel, Reuss, David E, Aldape, Ken, Abdullaev, Zied, Sahm, Felix, von Deimling, Andreas, Stichel, Damian

“…Pleomorphic xanthoastrocytoma (PXA) in its classic manifestation exhibits distinct morphological features and is assigned to CNS WHO grade 2 or grade 3…”
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Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation by Korshunov, Andrey, Okonechnikov, Konstantin, Schmitt-Hoffner, Felix, Ryzhova, Marina, Sahm, Felix, Stichel, Damian, Schrimpf, Daniel, Reuss, David E, Sievers, Philipp, Suwala, Abigail Kora, Kumirova, Ella, Zheludkova, Olga, Golanov, Andrey, Jones, David T W, Pfister, Stefan M, Kool, Marcel, von Deimling, Andreas

“…Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly malignant neoplasms posing diagnostic challenge due to a lack of defining…”
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Pediatric-type high-grade neuroepithelial tumors with CIC gene fusion share a common DNA methylation signature by Sievers, Philipp, Sill, Martin, Schrimpf, Daniel, Abdullaev, Zied, Donson, Andrew M., Lake, Jessica A., Friedel, Dennis, Scheie, David, Tynninen, Olli, Rauramaa, Tuomas, Vepsäläinen, Kaisa L., Samuel, David, Chapman, Rebecca, Grundy, Richard G., Pajtler, Kristian W., Tauziède-Espariat, Arnault, Métais, Alice, Varlet, Pascale, Snuderl, Matija, Jacques, Thomas S., Aldape, Kenneth, Reuss, David E., Korshunov, Andrey, Wick, Wolfgang, Pfister, Stefan M., von Deimling, Andreas, Sahm, Felix, Jones, David T. W.

“…Pediatric neoplasms in the central nervous system (CNS) show extensive clinical and molecular heterogeneity and are fundamentally different from those…”
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The flavonoid kaempferol sensitizes human glioma cells to TRAIL-mediated apoptosis by proteasomal degradation of survivin by Siegelin, Markus D, Reuss, David E, Habel, Antje, Herold-Mende, Christel, von Deimling, Andreas

“…Resistance to tumor necrosis factor–related apoptosis-inducing ligand (TRAIL/Apo2L) limits its potential as a drug for cancer therapy. Here, we report that…”
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Sensitivity of malignant peripheral nerve sheath tumor cells to TRAIL is augmented by loss of NF1 through modulation of MYC/MAD and is potentiated by curcumin through induction of ROS by Reuss, David E, Mucha, Jana, Hagenlocher, Christian, Ehemann, Volker, Kluwe, Lan, Mautner, Victor, von Deimling, Andreas

“…Malignant peripheral nerve sheath tumor (MPNST) is a rare aggressive form of sarcoma often associated with the tumor syndrome neurofibromatosis type 1 (NF1)…”
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Genome-wide methylation profiling and copy number analysis in atypical fibroxanthomas and pleomorphic dermal sarcomas indicate a similar molecular phenotype by Koelsche, Christian, Stichel, Damian, Griewank, Klaus G, Schrimpf, Daniel, Reuss, David E, Bewerunge-Hudler, Melanie, Vokuhl, Christian, Dinjens, Winand N M, Petersen, Iver, Mittelbronn, Michel, Cuevas-Bourdier, Adrian, Buslei, Rolf, Pfister, Stefan M, Flucke, Uta, Mechtersheimer, Gunhild, Mentzel, Thomas, von Deimling, Andreas

“…Atypical fibroxanthomas (AFX) and pleomorphic dermal sarcomas (PDS) are lesions of the skin with overlapping histologic features and unspecific molecular…”
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Rapid detection of 2-hydroxyglutarate in frozen sections of IDH mutant tumors by MALDI-TOF mass spectrometry by Longuespée, Rémi, Wefers, Annika K, De Vita, Elena, Miller, Aubry K, Reuss, David E, Wick, Wolfgang, Herold-Mende, Christel, Kriegsmann, Mark, Schirmacher, Peter, von Deimling, Andreas, Pusch, Stefan

“…All isocitrate dehydrogenase (IDH) mutant solid neoplasms exhibit highly elevated levels of D-2-hydroxyglutarate (D-2HG). Detection of 2HG in tumor tissues…”
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Heterogeneity of DNA methylation profiles and copy number alterations in 10782 adult-type glioblastomas, IDH-wildtype by Reuss, David E, Schrimpf, Daniel, Cherkezov, Asan, Suwala, Abigail K, Lausová, Tereza, Snuderl, Matija, Capper, David, Sill, Martin, Jones, David T W, Pfister, Stefan M, Sahm, Felix, von Deimling, Andreas

“…The morphological patterns leading to the diagnosis of glioblastoma may also commonly be observed in several other distinct tumor entities, which can result in…”
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