Search Results - "Retz, Daniel M"

Synthesis of labeled ambroxol and its major metabolites by Latli, Bachir, Hrapchak, Matt, Switek, Heinz-Karl, Retz, Daniel M., Krishnamurthy, Dhileepkumar, Senanayake, Chris H.

“…Ambroxol is a mucolytic agent used in the treatment of respiratory diseases. Herein, we report the synthesis of carbon‐14‐labeled ambroxol with the radioactive…”
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Benzoxaborole antimalarial agents. Part 3: design and syntheses of (carboxy-13C-3,3-2H2)-labeled and (3-14C)-labeled 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles by Zhang, Yong-Kang, Plattner, Jacob J., Easom, Eric E., Liu, Liang, Retz, Daniel M., Ge, Min, Zhou, Hui-Hong

“…Two new isotopically labeled compounds, (carboxy‐13C‐3,3‐2H2)‐7‐(2‐carboxyethyl)‐1,3‐dihydro‐1‐hydroxy‐2,1‐benzoxaborole (2) and…”
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Fenchylamine Sulfonamide Inhibitors of Amyloid β Peptide Production by the γ-Secretase Proteolytic Pathway:  Potential Small-Molecule Therapeutic Agents for the Treatment of Alzheimer's Disease by Rishton, Gilbert M, Retz, Daniel M, Tempest, Paul A, Novotny, James, Kahn, Steve, Treanor, James J. S, Lile, Jack D, Citron, Martin

“…The brain plaques associated with Alzheimer's disease (AD) are composed primarily of the amyloid beta peptides (A beta 40,42) which are produced from the…”
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Synthesis and pharmacological evaluation of 4a-phenanthrenamine derivatives acting at the phencyclidine binding site of the N-methyl-D-aspartate receptor complex by Bigge, Christopher F, Malone, Thomas C, Hays, Sheryl J, Johnson, Graham, Novak, Perry M, Lescosky, Leonard J, Retz, Daniel M, Ortwine, Daniel F, Probert, Albert W

“…A novel series of octahydrophenanthrenamines and their heterocyclic analogues have been synthesized as potential noncompetitive antagonists of the…”
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Synthesis of 1,4,7,8,9,10-hexahydro-9-methyl-6-nitropyrido[3,4-f]-quinoxaline-2,3-dione and related quinoxalinediones: characterization of .alpha.-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (and N-methyl-D-aspartate) receptor and anticonvulsant activity by Bigge, Christopher F, Malone, Thomas C, Boxer, Peter A, Nelson, Carrie B, Ortwine, Daniel F, Schelkun, Robert, Retz, Daniel M, Lescosky, Leonard J, Borosky, Susan A

“…Four related series of substituted quinoxalinediones containing angular fused-piperidine rings have been synthesized as…”
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Exploration of N-phosphonoalkyl-, N-phosphonoalkenyl-, and N-(phosphonoalkyl)phenyl-spaced .alpha.-amino acids as competitive N-methyl-D-aspartic acid antagonists by Bigge, Christopher F, Johnson, Graham, Ortwine, Daniel F, Drummond, James T, Retz, Daniel M, Brahce, Laura J, Coughenour, Linda L, Marcoux, Frank W, Probert, Albert W

“…A series of N-substituted alpha-amino acids containing terminal phosphonic acid groups has been synthesized as potential N-methyl-D-aspartate (NMDA) receptor…”
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