Search Results - "Rettenmeier, Albert W."
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Recent advances in the use of Sus scrofa (pig) as a model system for proteomic studies
Published in Proteomics (Weinheim) (01-02-2011)“…Of the numerous animal models available for proteomic studies only a small number have been successfully used in understanding human biology. To date, rodents…”
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Benzo[a]pyrene-induced metabolic shift from glycolysis to pentose phosphate pathway in the human bladder cancer cell line RT4
Published in Scientific reports (29-08-2017)“…Benzo[a]pyrene (B[a]P), a well-known polyaromatic hydrocarbon, is known for its lung carcinogenicity, however, its role in bladder cancer development is still…”
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Sensory irritation as a basis for setting occupational exposure limits
Published in Archives of toxicology (01-10-2014)“…There is a need of guidance on how local irritancy data should be incorporated into risk assessment procedures, particularly with respect to the derivation of…”
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Protein expression profiling in chemical carcinogenesis: A proteomic-based approach
Published in Proteomics (Weinheim) (01-02-2011)“…The simultaneous analysis of a wide array of proteins may provide valuable information on the activation and suppression of cellular systems at different…”
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Role of Intestinal Microbiota in Transformation of Bismuth and Other Metals and Metalloids into Volatile Methyl and Hydride Derivatives in Humans and Mice
Published in Applied and Environmental Microbiology (01-05-2008)“…The present study shows that feces samples of 14 human volunteers and isolated gut segments of mice (small intestine, cecum, and large intestine) are able to…”
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Subcellular Distribution of Inorganic and Methylated Arsenic Compounds in Human Urothelial Cells and Human Hepatocytes
Published in Drug metabolism and disposition (01-05-2008)“…Epidemiological studies have indicated that exposure of humans to inorganic arsenic in drinking water is associated with the occurrence of bladder cancer. The…”
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Benzo[a]pyrene mediated time- and dose-dependent alteration in cellular metabolism of primary pig bladder cells with emphasis on proline cycling
Published in Archives of toxicology (01-09-2019)“…Exposure to xenobiotic such as benzo[a]pyrene (B[a]P) induces metabolic changes, which have a considerable impact on the cellular response. Nevertheless, we…”
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Review on proteomic analyses of benzo[a]pyrene toxicity
Published in Proteomics (Weinheim) (01-06-2012)“…Benzo[a]pyrene (BaP), a five‐ring polycyclic aromatic hydrocarbon, is a well‐recognized environmental pollutant. Coal‐processing waste products, petroleum…”
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Methylated metal(loid) species in humans
Published in Metal ions in life sciences (01-01-2010)“…While the metal(loid)s arsenic, bismuth, and selenium (probably also tellurium) have been shown to be enzymatically methylated in the human body, this has not…”
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CBB staining protocol with higher sensitivity and mass spectrometric compatibility
Published in Electrophoresis (2010)“…Various CBB-based methods for staining proteins separated by 2-D gel electrophoresis were compared with regard to sensitivity and resolution. A modified Kang's…”
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Proteomic Analysis of Human Bladder Epithelial Cells by 2D Blue Native SDS-PAGE Reveals TCDD-Induced Alterations of Calcium and Iron Homeostasis Possibly Mediated by Nitric Oxide
Published in Journal of proteome research (02-01-2015)“…A proteomic analysis of the interaction among multiprotein complexes involved in 2,3,7,8-dibenzo-p-dioxin (TCDD)-mediated toxicity in urinary bladder…”
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Integrated proteomic and metabolomic analysis to assess the effects of pure and benzo[a]pyrene-loaded carbon black particles on energy metabolism and motility in the human endothelial cell line EA.hy926
Published in Archives of toxicology (01-04-2014)“…Epidemiological studies suggest that environmental exposure to airborne particulate matter may promote cardiovascular diseases; however, it is not clear…”
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Benzo[a]pyrene-mediated toxicity in primary pig bladder epithelial cells: A proteomic approach
Published in Journal of proteomics (24-06-2013)“…The studies described in this paper deal with a sequence of cellular events induced by the environmental toxicant benzo[a]pyrene (B[a]P) that were investigated…”
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Exposure of primary porcine urothelial cells to benzo(a)pyrene: in vitro uptake, intracellular concentration, and biological response
Published in Archives of toxicology (01-12-2012)“…More than 90 % of all bladder cancers are transitional cell carcinomas arising from the cells lining the inside of the hollow organ (uroepithelium). Cell…”
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Gel-based separation of phosphoproteins in samples stored in urea/thiourea after precipitation by lanthanum chloride
Published in Electrophoresis (01-02-2013)“…The recent introduction of the La3+ precipitation method for the enrichment of phosphoproteins allows a gel‐based analysis of these posttranslationally…”
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Proteome and phosphoproteome of primary cultured pig urothelial cells
Published in Electrophoresis (01-12-2011)“…Epithelial tissue lining the inner side of the urinary bladder is the most common target for bladder cancer‐related diseases. Bladders of freshly slaughtered…”
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Precipitation by lanthanum ions: A straightforward approach to isolating phosphoproteins
Published in Journal of proteomics (21-12-2011)“…Posttranslational modification (PTM) of proteins, particularly phosphorylation, is a key element in the regulation of cell functions. In many signal…”
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Modulation of intracellular calcium homeostasis by trimethyltin chloride in human tumour cells: Neuroblastoma SY5Y and cervix adenocarcinoma HeLa S3
Published in Toxicology (Amsterdam) (01-12-2005)“…Physiological modifications of intracellular Ca 2+ ([Ca 2+] i) levels trigger and/or regulate a diversity of cellular activities (e.g. neurotransmitter…”
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The use of mini-organ cultures of human upper aerodigestive tract epithelia in ecogenotoxicology
Published in Mutation research (11-07-2004)“…The carcinogenic potential of xenobiotics and possible confounders are often difficult to differentiate in in vivo studies. In contrast, in vitro studies allow…”
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