Search Results - "Reto, Guler"

The gut microbiome in tuberculosis susceptibility and treatment response: guilty or not guilty? by Eribo, Osagie A., du Plessis, Nelita, Ozturk, Mumin, Guler, Reto, Walzl, Gerhard, Chegou, Novel N.

“…Although tuberculosis (TB) is a curable disease, it remains the foremost cause of death from a single pathogen. Globally, approximately 1.6 million people died…”
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Transcriptional landscape of Mycobacterium tuberculosis infection in macrophages by Roy, Sugata, Schmeier, Sebastian, Kaczkowski, Bogumil, Arner, Erik, Alam, Tanvir, Ozturk, Mumin, Tamgue, Ousman, Parihar, Suraj P., Kawaji, Hideya, Itoh, Masayoshi, Lassmann, Timo, Carninci, Piero, Hayashizaki, Yoshihide, Forrest, Alistair R. R., Guler, Reto, Bajic, Vladimir B., Brombacher, Frank, Suzuki, Harukazu

“…Mycobacterium tuberculosis (Mtb) infection reveals complex and dynamic host-pathogen interactions, leading to host protection or pathogenesis. Using a unique…”
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Targeting Batf2 for infectious diseases and cancer by Guler, Reto, Roy, Sugata, Suzuki, Harukazu, Brombacher, Frank

“…The family members Batf, Batf2 and Batf3 belong to a class of transcription factors containing basic leucine zipper domains that regulate various immunological…”
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Transcriptionally induced enhancers in the macrophage immune response to Mycobacterium tuberculosis infection by Denisenko, Elena, Guler, Reto, Mhlanga, Musa, Suzuki, Harukazu, Brombacher, Frank, Schmeier, Sebastian

“…Tuberculosis is a life-threatening infectious disease caused by Mycobacterium tuberculosis (M.tb). M.tb subverts host immune responses to build a favourable…”
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Targeting Molecular Inflammatory Pathways in Granuloma as Host-Directed Therapies for Tuberculosis by Guler, Reto, Ozturk, Mumin, Sabeel, Solima, Motaung, Bongani, Parihar, Suraj P, Thienemann, Friedrich, Brombacher, Frank

“…Globally, more than 10 million people developed active tuberculosis (TB), with 1.4 million deaths in 2020. In addition, the emergence of drug-resistant strains…”
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Batf2/Irf1 induces inflammatory responses in classically activated macrophages, lipopolysaccharides, and mycobacterial infection by Roy, Sugata, Guler, Reto, Parihar, Suraj P, Schmeier, Sebastian, Kaczkowski, Bogumil, Nishimura, Hajime, Shin, Jay W, Negishi, Yutaka, Ozturk, Mumin, Hurdayal, Ramona, Kubosaki, Atsutaka, Kimura, Yasumasa, de Hoon, Michiel J L, Hayashizaki, Yoshihide, Brombacher, Frank, Suzuki, Harukazu

“…Basic leucine zipper transcription factor Batf2 is poorly described, whereas Batf and Batf3 have been shown to play essential roles in dendritic cell, T cell,…”
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MIREyA: a computational approach to detect miRNA-directed gene activation [version 2; peer review: 1 approved, 2 approved with reservations] by Elizarova, Anna, Ozturk, Mumin, Guler, Reto, Medvedeva, Yulia A

“…Emerging studies demonstrate the ability of microRNAs (miRNAs) to activate genes via different mechanisms. Specifically, miRNAs may trigger an enhancer…”
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The C-type Lectin Receptor CLECSF8 (CLEC4D) Is Expressed by Myeloid Cells and Triggers Cellular Activation through Syk Kinase by Graham, Lisa M., Gupta, Vandana, Schafer, Georgia, Reid, Delyth M., Kimberg, Matti, Dennehy, Kevin M., Hornsell, William G., Guler, Reto, Campanero-Rhodes, Maria A., Palma, Angelina S., Feizi, Ten, Kim, Stella K., Sobieszczuk, Peter, Willment, Janet A., Brown, Gordon D.

“…Background: C-type lectins play important roles in immunity and homeostasis. Results: CLECSF8 is expressed on neutrophils and monocytes and can mediate…”
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Differential Targeting of c-Maf, Bach-1, and Elmo-1 by microRNA-143 and microRNA-365 Promotes the Intracellular Growth of Mycobacterium tuberculosis in Alternatively IL-4/IL-13 Activated Macrophages by Tamgue, Ousman, Gcanga, Lorna, Ozturk, Mumin, Whitehead, Lauren, Pillay, Shandre, Jacobs, Raygaana, Roy, Sugata, Schmeier, Sebastian, Davids, Malika, Medvedeva, Yulia A, Dheda, Keertan, Suzuki, Harukazu, Brombacher, Frank, Guler, Reto

“…(Mtb) can subvert the host defense by skewing macrophage activation toward a less microbicidal alternative activated state to avoid classical effector killing…”
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Antisense Therapy for Infectious Diseases by Buthelezi, Lwanda Abonga, Pillay, Shandre, Ntuli, Noxolo Nokukhanya, Gcanga, Lorna, Guler, Reto

“…Infectious diseases, particularly Tuberculosis (TB) caused by , pose a significant global health challenge, with 1.6 million reported deaths in 2021, making it…”
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Evaluation of Berberine as an Adjunct to TB Treatment by Ozturk, Mumin, Chia, Julius E, Hazra, Rudranil, Saqib, Mohd, Maine, Rebeng A, Guler, Reto, Suzuki, Harukazu, Mishra, Bibhuti B, Brombacher, Frank, Parihar, Suraj P

“…Tuberculosis (TB) is the global health problem with the second highest number of deaths from a communicable disease after COVID-19. Although TB is curable,…”
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IL-4-Responsive B Cells Are Detrimental During Chronic Tuberculosis Infection in Mice by Parihar, Suraj P., Ozturk, Mumin, Höft, Maxine A., Chia, Julius E., Guler, Reto, Keeton, Roanne, van Rensburg, Ilana C., Loxton, Andre G., Brombacher, Frank

“…In tuberculosis, T cell-mediated immunity is extensively studied whilst B cells received limited attention in human and mice. Of interest, Mycobacterium…”
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Deletion of N-acetylmuramyl-L-alanine amidases alters the host immune response to Mycobacterium tuberculosis infection by Kieswetter, Nathan Scott, Ozturk, Mumin, Jones, Shelby-Sara, Senzani, Sibusiso, Chengalroyen, Melissa Dalcina, Brombacher, Frank, Kana, Bavesh, Guler, Reto

“…Peptidoglycan (PG), a heteropolysaccharide component of the mycobacterial cell wall can be shed during tuberculosis infection with immunomodulatory…”
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Comparing gene expression profiles of adults with isolated spinal tuberculosis to disseminated spinal tuberculosis identified by 18FDG-PET/CT at time of diagnosis, 6- and 12-months follow-up: classifying clinical stages of spinal tuberculosis and monitoring treatment response (Spinal TB X cohort study) by Scherer, Julian, Mukasa, Sandra L, Wolmarans, Karen, Guler, Reto, Kotze, Tessa, Song, Taeksun, Dunn, Robert, Laubscher, Maritz, Pape, Hans-Christoph, Held, Michael, Thienemann, Friedrich

“…Abstract Background Tuberculosis (TB) is one of the top ten causes of death worldwide, with approximately 10 million cases annually. Focus has been on…”
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Redefining the transcriptional regulatory dynamics of classically and alternatively activated macrophages by deepCAGE transcriptomics by Roy, Sugata, Schmeier, Sebastian, Arner, Erik, Alam, Tanvir, Parihar, Suraj P, Ozturk, Mumin, Tamgue, Ousman, Kawaji, Hideya, de Hoon, Michiel J L, Itoh, Masayoshi, Lassmann, Timo, Carninci, Piero, Hayashizaki, Yoshihide, Forrest, Alistair R R, Bajic, Vladimir B, Guler, Reto, Brombacher, Frank, Suzuki, Harukazu

“…Classically or alternatively activated macrophages (M1 and M2, respectively) play distinct and important roles for microbiocidal activity, regulation of…”
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COVID-19Base v3: Update of the knowledgebase for drugs and biomedical entities linked to COVID-19 by Basit, Syed Abdullah, Qureshi, Rizwan, Musleh, Saleh, Guler, Reto, Rahman, M Sohel, Biswas, Kabir H, Alam, Tanvir

“…COVID-19 has taken a huge toll on our lives over the last 3 years. Global initiatives put forward by all stakeholders are still in place to combat this…”
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Lyl1-deficiency promotes inflammatory responses and increases mycobacterial burden in response to Mycobacterium tuberculosis infection in mice by Jones, Shelby-Sara, Ozturk, Mumin, Kieswetter, Nathan Scott, Poswayo, Sibongiseni K L, Hazra, Rudranil, Tamgue, Ousman, Parihar, Suraj P, Suzuki, Harukazu, Brombacher, Frank, Guler, Reto

“…Lymphoblastic leukemia 1 (Lyl1) is a well-studied transcription factor known to exhibit oncogenic potential in various forms of leukemia with pivotal roles in…”
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Simvastatin enhances protection against Listeria monocytogenes infection in mice by counteracting Listeria-induced phagosomal escape by Parihar, Suraj P, Guler, Reto, Lang, Dirk M, Suzuki, Harukazu, Marais, A David, Brombacher, Frank

“…Statins are well-known cholesterol lowering drugs targeting HMG-CoA-reductase, reducing the risk of coronary disorders and hypercholesterolemia. Statins are…”
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IL-4Rα-dependent alternative activation of macrophages is not decisive for Mycobacterium tuberculosis pathology and bacterial burden in mice by Guler, Reto, Parihar, Suraj P, Savvi, Suzana, Logan, Erin, Schwegmann, Anita, Roy, Sugata, Nieuwenhuizen, Natalie E, Ozturk, Mumin, Schmeier, Sebastian, Suzuki, Harukazu, Brombacher, Frank

“…Classical activation of macrophages (caMph or M1) is crucial for host protection against Mycobacterium tuberculosis (Mtb) infection. Evidence suggests that…”
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To treat or not to treat tuberculosis –clinical decision making in patients with previous pulmonary tuberculosis using 18F-FDG PET/CT by Günther, Gunar, Abu- Hussain, Nebal, Keller, Peter M., Guler, Reto, Mukasa, Sandra L., Wolmarans, Karen, Thienemann, Friedrich

“…Post-tuberculosis (TB) radiological changes and symptoms can mimic TB. PCR-based diagnostic tests can show positive results, suggesting the presence of…”
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