Search Results - "Retana, Ana M. Ochoa"
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3D Bioprinted Hydroxyapatite or Graphene Oxide Containing Nanocellulose‐Based Scaffolds for Bone Regeneration
Published in Macromolecular bioscience (01-11-2022)“…Bone tissue is usually damaged after big traumas, tumors, and increasing aging‐related diseases such as osteoporosis and osteoarthritis. Current treatments are…”
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Diastereoselective ZnCl2-Mediated Joullié–Ugi Three-Component Reaction for the Preparation of Phosphorylated N-Acylaziridines from 2H-Azirines
Published in Molecules (Basel, Switzerland) (27-02-2024)“…We disclose a direct approach to the diastereoselective synthesis of phosphorus substituted N-acylaziridines based on a one-pot ZnCl2-catalyzed Joullié–Ugi…”
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3
Synthesis of α-Aminophosphonic Acid Derivatives Through the Addition of O- and S-Nucleophiles to 2H-Azirines and Their Antiproliferative Effect on A549 Human Lung Adenocarcinoma Cells
Published in Molecules (Basel, Switzerland) (22-07-2020)“…This work reports a straightforward regioselective synthetic methodology to prepare α-aminophosphine oxides and phosphonates through the addition of oxygen and…”
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4
Synthesis and Antiproliferative Activity of Phosphorus Substituted 4-Cyanooxazolines, 2-Aminocyanooxazolines, 2-Iminocyanooxazolidines and 2-Aminocyanothiazolines by Rearrangement of Cyanoaziridines
Published in Molecules (Basel, Switzerland) (14-07-2021)“…Several phosphorus-substituted N-acylated cyanoaziridines 2 and N-carbamoylated cyanoziridines 5 were prepared in good to high yields. N-Acylated…”
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5
Multicomponent reactions (MCRs): a useful access to the synthesis of benzo-fused γ-lactams
Published in Beilstein journal of organic chemistry (2019)“…Benzo-fused γ-lactam rings such as isoindolin-2-ones and 2-oxindoles are part of the structure of many pharmaceutically active molecules. They can be often…”
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Catalytic Asymmetric Darzens and Aza‐Darzens Reactions for the Synthesis of Chiral Epoxides and Aziridines
Published in ChemCatChem (22-11-2018)“…This review presents an overview on the recent advances in the catalytic enantioselective Darzens and aza‐Darzens reactions for the synthesis of enantiopure…”
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7
Regioselective Synthesis of Fluoroalkylated β-Aminophosphorus Derivatives and Aziridines from Phosphorylated Oximes and Nucleophilic Reagents
Published in Journal of organic chemistry (04-08-2006)“…A simple and efficient stereoselective synthesis of fluoroalkyl substituted aziridine-2-phosphine oxides and -phosphonates by diastereoselective addition of…”
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8
Synthesis of Fluoroalkylated β-Aminophosphonates and Pyridines from Primary β-Enaminophosphonates
Published in Journal of organic chemistry (20-06-2008)“…A simple and efficient stereoselective synthesis of fluorine containing β-aminophosphonates by reduction of β-enaminophosphonates is described. Reduction with…”
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9
Reaction of 2H-Azirine Phosphine Oxide and -Phosphonates with Nucleophiles. Stereoselective Synthesis of Functionalized Aziridines and α- and β-Aminophosphorus Derivatives
Published in Journal of organic chemistry (28-10-2005)“…A simple and efficient stereoselective synthesis of aziridine-2-phosphonate 3, and -phosphine oxide 5 by diastereoselective addition of Grignard reagents to…”
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10
First synthesis of merged hybrids phosphorylated azirino[2,1-b]benzo[e][1,3]oxazine derivatives as anticancer agents
Published in European journal of medicinal chemistry (01-01-2020)“…This work describes a straightforward diastereoselective synthetic access to azirino[2,1-b]benzo[e][1,3]oxazines containing phosphorus substituents such as…”
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Synthesis and biological evaluation of cyanoaziridine phosphine oxides and phosphonates with antiproliferative activity
Published in European journal of medicinal chemistry (01-02-2019)“…This work reports an efficient diastereoselective synthetic methodology for the preparation of phosphorus substituted cyanoaziridines through the nucleophilic…”
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12
Easy and efficient synthesis of enantiomerically enriched 2H-azirines derived from phosphonates
Published in Tetrahedron letters (08-07-2000)Get full text
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13
Reaction of 2H‑Azirine-Phosphine Oxides and -Phosphonates with Enolates Derived from β‑Keto Esters
Published in Journal of organic chemistry (04-01-2016)“…Cyclopenta[b]-pyrrole-2-phosphine oxides 4a and -phosphonates 4b,c are generated by the addition of cyclic enolates derived from ethyl…”
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14
Selective Synthesis of Substituted Pyrrole-2-phosphine Oxides and -phosphonates from 2H-Azirines and Enolates from Acetyl Acetates and Malonates
Published in Journal of organic chemistry (18-11-2011)“…A simple and efficient selective synthesis of 1H-pyrrole-2-phosphine oxides 3 and -phosphonates 7 by addition of enolates derived from acetyl acetates to…”
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15
Fluoroalkylated α,β-Unsaturated Imines as Synthons for the Preparation of Fluorinated Triazinane-2,4-diones and Dihydropyrimidin-2(1H)‑ones
Published in Journal of organic chemistry (06-06-2014)“…A regioselective addition of isocyanates to fluoroalkylated α,β-unsaturated imines 1 is described. Fluoroalkyl-substituted triazinane-2,4-diones 4 are obtained…”
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16
Reaction of phosphinyl nitrosoalkenes with electron-rich heterocycles
Published in Phosphorus, sulfur, and silicon and the related elements (27-05-2019)“…Here we described the behavior of phosphinyl nitrosoalkenes with indole, pyrrole and 2,5-dimethylpyrrole. 3-Substituted indoles have been prepared through the…”
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17
Regioselective Conjugate Addition of Nitriles to [alpha],[beta]-Unsaturated Imines: Synthesis of Fluorinated Primary Enamines and 2-Aminopyridine Derivatives
Published in European journal of organic chemistry (01-09-2013)“…The regioselective Michael addition of the carbanion of 2-phenylacetonitrile (R2 = Ph) and malononitrile (R2 = CN) to fluoroalkylated…”
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18
Efficient synthesis of fluorinated α- and β-amino nitriles from fluoroalkylated α,β-unsaturated imines
Published in Tetrahedron (25-02-2011)“…A simple and efficient synthesis of fluoroalkylated α-amino nitrile ( 4) derivatives by regioselective 1,2-addition of trimethylsilyl cyanide to…”
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Fluoroalkyl α,β-Unsaturated Imines. Valuable Synthetic Intermediates from Primary Fluorinated Enamine Phosphonates
Published in Organic letters (07-03-2002)“…A simple method for the preparation of fluoroalkyl allylamines or α,β-unsaturated ketones by an olefination reaction of primary enamine phosphonates and…”
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20
Fluoroalkylated α,β-Unsaturated Imines: Efficient and Versatile Substrates for the Synthesis of Fluorinated Vinylogous β-Amino Esters and 3,4-Dihydropyridin-2-ones
Published in European Journal of Organic Chemistry (01-12-2010)“…A simple and efficient synthesis of vinylogous fluoroalkylated β‐amino mono‐ (4) and diester (9) derivatives by the regioselective 1,2‐addition of enolates…”
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