Chitosan/Polyvinyl Alcohol/Tea Tree Essential Oil Composite Films for Biomedical Applications

Tissue engineering is crucial, since its early adoption focused on designing biocompatible materials that stimulate cell adhesion and proliferation. In this sense, scaffolds made of biocompatible and resistant materials became the researchers’ focus on biomedical applications. Humans have used essen...

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Bibliographic Details
Published in:	Polymers Vol. 13; no. 21; p. 3753
Main Authors:	Castro, Jorge Iván, Valencia-Llano, Carlos Humberto, Valencia Zapata, Mayra Eliana, Restrepo, Yilmar Joan, Mina Hernandez, José Herminsul, Navia-Porras, Diana Paola, Valencia, Yamid, Valencia, Cesar, Grande-Tovar, Carlos David
Format:	Journal Article
Language:	English
Published:	Basel MDPI AG 29-10-2021 MDPI
Subjects:	Aluminum Antioxidants Biocompatibility Biomedical engineering Biomedical materials Biopolymers Body fluids Calcium chloride Cell adhesion Cell adhesion & migration Cell growth Chitosan Essential oils Fourier transforms Fungicides Insecticide resistance Insecticides Mechanical properties membrane Modulus of elasticity Morphology Oils & fats Particle size Polymers Polyvinyl alcohol Scaffolds Scanning electron microscopy Sodium chloride tea tree essential oil Tissue engineering Ultrasonic imaging Palo Alto California United States > US Madrid Spain Japan Spain
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Summary:	Tissue engineering is crucial, since its early adoption focused on designing biocompatible materials that stimulate cell adhesion and proliferation. In this sense, scaffolds made of biocompatible and resistant materials became the researchers’ focus on biomedical applications. Humans have used essential oils for a long time to take advantage of their antifungal, insecticide, antibacterial, and antioxidant properties. However, the literature demonstrating the use of essential oils for stimulating biocompatibility in new scaffold designs is scarce. For that reason, this work describes the synthesis of four different film composites of chitosan/polyvinyl alcohol/tea tree (Melaleuca alternifolia), essential oil (CS/PVA/TTEO), and the subdermal implantations after 90 days in Wistar rats. According to the Young modulus, DSC, TGA, mechanical studies, and thermal studies, there was a reinforcement effect with the addition of TTEO. Morphology and energy-dispersive (EDX) analysis after the immersion in simulated body fluid (SBF) exhibited a light layer of calcium chloride and sodium chloride generated on the material’s surface, which is generally related to a bioactive material. Finally, the biocompatibility of the films was comparable with porcine collagen, showing better signs of resorption as the amount of TTEO was increased. These results indicate the potential application of the films in long-term biomedical needs.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2073-4360 2073-4360
DOI:	10.3390/polym13213753