Search Results - "Restifo, Nicholas"

Adoptive cell transfer as personalized immunotherapy for human cancer by Rosenberg, Steven A., Restifo, Nicholas P.

“…Adoptive cell therapy (ACT) is a highly personalized cancer therapy that involves administration to the cancer-bearing host of immune cells with direct…”
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Epigenetic control of CD8+ T cell differentiation by Henning, Amanda N., Roychoudhuri, Rahul, Restifo, Nicholas P.

“…Key Points According to the linear differentiation model, progressive changes to gene expression and the epigenetic landscape regulate the gradual acquisition…”
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Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy by Kishton, Rigel J., Sukumar, Madhusudhanan, Restifo, Nicholas P.

“…Cancer immunotherapy is an increasingly successful strategy for the treatment of patients who have advanced or conventional therapy-resistant cancers. T cells…”
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Essentials of Th17 cell commitment and plasticity by Muranski, Pawel, Restifo, Nicholas P.

“…CD4+ T helper (Th) cells exist in a variety of epigenetic states that determine their function, phenotype, and capacity for persistence. These polarization…”
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Nutrient Competition: A New Axis of Tumor Immunosuppression by Sukumar, Madhusudhanan, Roychoudhuri, Rahul, Restifo, Nicholas P.

“…It is thought that cancer cells engage in Warburg metabolism to meet intrinsic biosynthetic requirements of cell growth and proliferation. Papers by Chang…”
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Acquired resistance to immunotherapy and future challenges by Restifo, Nicholas P., Smyth, Mark J., Snyder, Alexandra

“…Many patients have now received various types of immunotherapy, so we asked three scientists to give their views on whether acquired resistance to…”
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TH17 cells in tumour immunity and immunotherapy by Zou, Weiping, Restifo, Nicholas P.

“…Key Points T helper 17 (T H 17) cells are found in human and mouse tumours. However, the numbers of T H 17 cells are limited and are lower than that of other T…”
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T(H)17 cells in tumour immunity and immunotherapy by Zou, Weiping, Restifo, Nicholas P

“…T helper 17 (T(H)17) cells have well-described roles in autoimmune disease. Recent evidence suggests that this effector T cell subset is also involved in…”
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Developing neoantigen-targeted T cell–based treatments for solid tumors by Yamamoto, Tori N., Kishton, Rigel J., Restifo, Nicholas P.

“…Stimulating an immune response against cancer through adoptive transfer of tumor-targeting lymphocytes has shown great promise in hematological malignancies,…”
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Lineage relationship of effector and memory T cells by Restifo, Nicholas P, Gattinoni, Luca

“…Adaptive immunity is characterized by the ability to form long-lived immunological memory. Upon re-exposure to antigen, memory T cells respond more rapidly and…”
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Paths to stemness: building the ultimate antitumour T cell by Gattinoni, Luca, Klebanoff, Christopher A., Restifo, Nicholas P.

“…Key Points T lymphocytes transition through progressive stages of differentiation that are characterized by a stepwise loss of functional and therapeutic…”
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Human memory T cells: generation, compartmentalization and homeostasis by Farber, Donna L., Yudanin, Naomi A., Restifo, Nicholas P.

“…Key Points Most of our understanding of memory T cell generation, function and maintenance comes from mouse studies, which cannot recapitulate the exposure to…”
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Cellular Constituents of Immune Escape within the Tumor Microenvironment by KERKAR, Sid P, RESTIFO, Nicholas P

“…Established tumors are complex masses that contain not only neoplastic cells but also nontransformed cellular elements such as stromal cells, the…”
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Adoptive immunotherapy for cancer: harnessing the T cell response by Restifo, Nicholas P., Dudley, Mark E., Rosenberg, Steven A.

“…Key Points Populations of T cells that are specific for tumour-associated antigens can be expanded to generate large numbers of cells and transferred into…”
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Prospects for gene-engineered T cell immunotherapy for solid cancers by Klebanoff, Christopher A, Rosenberg, Steven A, Restifo, Nicholas P

“…Prospects for engineered T cell therapy of solid tumors. Adoptive transfer of receptor-engineered T cells has produced impressive results in treating patients…”
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Synthetic soldiers: Turning T cells into immortal warriors by Restifo, Nicholas P, Gattinoni, Luca

“…The creation of synthetic T cell states has captivated the field of cell-based therapies. Wang et al. (https://doi.org/10.1084/jem.20232368) describe how…”
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Reassessing target antigens for adoptive T-cell therapy by Hinrichs, Christian S, Restifo, Nicholas P

“…Adoptive T-cell therapy can target and kill widespread malignant cells thereby inducing durable clinical responses in melanoma and selected other malignances…”
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Ionic immune suppression within the tumour microenvironment limits T cell effector function by Eil, Robert, Vodnala, Suman K., Clever, David, Klebanoff, Christopher A., Sukumar, Madhusudhanan, Pan, Jenny H., Palmer, Douglas C., Gros, Alena, Yamamoto, Tori N., Patel, Shashank J., Guittard, Geoffrey C., Yu, Zhiya, Carbonaro, Valentina, Okkenhaug, Klaus, Schrump, David S., Linehan, W. Marston, Roychoudhuri, Rahul, Restifo, Nicholas P.

“…Potassium ions released by necrotic cells in tumours impair T cell function by increasing the intracellular potassium concentration in vitro and in vivo …”
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MicroRNA-155 Is Required for Effector CD8+ T Cell Responses to Virus Infection and Cancer by Dudda, Jan C., Salaun, Bruno, Ji, Yun, Palmer, Douglas C., Monnot, Gwennaelle C., Merck, Estelle, Boudousquie, Caroline, Utzschneider, Daniel T., Escobar, Thelma M., Perret, Rachel, Muljo, Stefan A., Hebeisen, Michael, Rufer, Nathalie, Zehn, Dietmar, Donda, Alena, Restifo, Nicholas P., Held, Werner, Gattinoni, Luca, Romero, Pedro

“…MicroRNAs (miRNAs) regulate the function of several immune cells, but their role in promoting CD8+ T cell immunity remains unknown. Here we report that…”
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Defining ‘T cell exhaustion’ by Blank, Christian U., Haining, W. Nicholas, Held, Werner, Hogan, Patrick G., Kallies, Axel, Lugli, Enrico, Lynn, Rachel C., Philip, Mary, Rao, Anjana, Restifo, Nicholas P., Schietinger, Andrea, Schumacher, Ton N., Schwartzberg, Pamela L., Sharpe, Arlene H., Speiser, Daniel E., Wherry, E. John, Youngblood, Benjamin A., Zehn, Dietmar

“…‘T cell exhaustion’ is a broad term that has been used to describe the response of T cells to chronic antigen stimulation, first in the setting of chronic…”
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