Prevalence of rotavirus and human bocavirus in immunosuppressed individuals after renal transplantation in the Northern Region of Brazil

Prevalence of rotavirus and human bocavirus in immunosuppressed individuals after renal transplantation in the Northern Region of Brazil

Immunosuppressive therapy causes severe impairment of host defense and diarrhea is a frequent complication in renal transplant recipients. This study aimed to describe the occurrence of Rotavirus A (RVA) and Human Bocavirus (HBoV) in fecal samples of immunosuppressed patients submitted to renal tran...

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Bibliographic Details
Published in:Journal of medical virology Vol. 91; no. 12; pp. 2125 - 2133
Main Authors: Castro, Luanda R. P., Calvet, Flávio C., Sousa, Karoline L., Silva, Victor P., Lobo, Patrícia S., Penha, Edvaldo T., Guerra, Sylvia F. S., Bezerra, Delana A. M., Mascarenhas, Joana D. P., Pinheiro, Helder H. C., Costa, Igor B., Resque, Hugo R., Soares, Luana S.
Format: Journal Article
Language:English
Published: United States Wiley Subscription Services, Inc 01-12-2019
Subjects:
Correlation analysis
Diarrhea
Epidemiology
Genotypes
Health risk assessment
Human Bocavirus
Immunosuppressive agents
Kidney transplantation
Kidney transplants
Patients
Phylogeny
Rotavirus
Sewage
Statistical analysis
Statistical methods
Transplantation
Transplants & implants
Virology
Viruses
Waste treatment
Wastewater treatment
Water treatment
Brazil
rotavirus
Human Bocavirus
kidney transplantation
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Summary:Immunosuppressive therapy causes severe impairment of host defense and diarrhea is a frequent complication in renal transplant recipients. This study aimed to describe the occurrence of Rotavirus A (RVA) and Human Bocavirus (HBoV) in fecal samples of immunosuppressed patients submitted to renal transplantation during posttransplant follow‐up. A longitudinal study was carried out involving a 25‐patient cohort, selected for kidney transplantation. A total of 126 fecal samples were collected between May 2014 and May 2016. Molecular techniques were used to detect and characterize circulating RVA and HBoV genotypes and statistical analysis were applied to verify the association between epidemiological and clinical characteristics. The prevalence of RVA and HBoV was 24% (6/25) and 40% (10/25), respectively. Among RVA and HBoV positive cases, the majority was female; did not conduct water treatment nor had adequate sewage facilities. The most detected genotypes were RVA G3 (62.5%) and HBoV‐3 (95%). Phylogenetic analysis of HBoV strains indicated that studied samples were similar to those found in Asian and American countries. The present study point out the circulation of these viral agents among immunosuppressed individuals and these findings will enable the construction of new knowledge and care perspectives on the cause of diarrhea in this population. Highlight RVA and HBoV present high frequency among immunosuppressed individuals after kidney transplant. Prolonged excretion of HBoV has been observed in immunosuppressed individuals.
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ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.25569