Search Results - "Resovi, Andrea"

Soluble stroma‐related biomarkers of pancreatic cancer by Resovi, Andrea, Bani, Maria Rosa, Porcu, Luca, Anastasia, Alessia, Minoli, Lucia, Allavena, Paola, Cappello, Paola, Novelli, Francesco, Scarpa, Aldo, Morandi, Eugenio, Falanga, Anna, Torri, Valter, Taraboletti, Giulia, Belotti, Dorina, Giavazzi, Raffaella

“…The clinical management of pancreatic ductal adenocarcinoma (PDAC) is hampered by the lack of reliable biomarkers. This study investigated the value of soluble…”
Get full text

Fibronectin fragments generated by pancreatic trypsin act as endogenous inhibitors of pancreatic tumor growth by Resovi, Andrea, Persichitti, Perla, Brunelli, Laura, Minoli, Lucia, Borsotti, Patrizia, Garattini, Giulia, Tironi, Matteo, Dugnani, Erica, Redegalli, Miriam, De Simone, Giulia, Pastorelli, Roberta, Bani, Maria Rosa, Piemonti, Lorenzo, Mosher, Deane F, Giavazzi, Raffaella, Taraboletti, Giulia, Belotti, Dorina

“…The pancreatic microenvironment has a defensive role against cancer but it can acquire tumor-promoting properties triggered by multiple mechanisms including…”
Get full text

CCN-Based Therapeutic Peptides Modify Pancreatic Ductal Adenocarcinoma Microenvironment and Decrease Tumor Growth in Combination with Chemotherapy by Resovi, Andrea, Borsotti, Patrizia, Ceruti, Tommaso, Passoni, Alice, Zucchetti, Massimo, Berndt, Alexander, Riser, Bruce L, Taraboletti, Giulia, Belotti, Dorina

“…The prominent desmoplastic stroma of pancreatic ductal adenocarcinoma (PDAC) is a determinant factor in tumor progression and a major barrier to the access of…”
Get full text

Inhibition of SIRT2 Potentiates the Anti-motility Activity of Taxanes: Implications for Antineoplastic Combination Therapies by Bonezzi, Katiuscia, Belotti, Dorina, North, Brian J, Ghilardi, Carmen, Borsotti, Patrizia, Resovi, Andrea, Ubezio, Paolo, Riva, Antonella, Giavazzi, Raffaella, Verdin, Eric, Taraboletti, Giulia

“…Abstract Taxanes are potent inhibitors of cell motility, a property implicated in their antiangiogenic and antimetastatic activity and unrelated to their…”
Get full text

Thrombospondin-1 promotes mesenchymal stromal cell functions via TGFβ and in cooperation with PDGF by Belotti, Dorina, Capelli, Chiara, Resovi, Andrea, Introna, Martino, Taraboletti, Giulia

“…Mesenchymal stromal cells (MSC) are characterized by unique tropism for wounded tissues, high differentiating capacity, ability to induce tissue repair, and…”
Get full text

Current understanding of the thrombospondin-1 interactome by Resovi, Andrea, Pinessi, Denise, Chiorino, Giovanna, Taraboletti, Giulia

“…The multifaceted action of thrombospondin-1 (TSP-1) depends on its ability to physically interact with different ligands, including structural components of…”
Get full text

Abstract 198: The T3R domain of thrombospondin-1 delays tumor growth and improves tumor response to chemotherapy by remodeling the tumor vasculature by Pinessi, Denise, Resovi, Andrea, Morosi, Lavinia, Borsotti, Patrizia, Berndt, Alexander, Giavazzi, Raffaella, Zucchetti, Massimo, Taraboletti, Giulia

“…Abstract The disorganized and inefficient nature of the tumor vasculature affects the delivery and activity of antineoplastic treatments. Certain…”
Get full text

Thrombospondin-1 promotes mesenchymal stromal cell functions via TGFß and in cooperation with PDGF by Belotti, Dorina, Capelli, Chiara, Resovi, Andrea, Introna, Martino, Taraboletti, Giulia

“…Mesenchymal stromal cells (MSC) are characterized by unique tropism for wounded tissues, high differentiating capacity, ability to induce tissue repair, and…”
Get full text

Tumor vascular remodeling by thrombospondin-1 enhances drug delivery and antineoplastic activity by Pinessi, Denise, Resovi, Andrea, Sangalli, Fabio, Morosi, Lavinia, Zentilin, Lorena, Borsotti, Patrizia, Carlessi, Elena, Passoni, Alice, Davoli, Enrico, Belotti, Dorina, Giavazzi, Raffaella, Giacca, Mauro, Valbusa, Giovanni, Berndt, Alexander, Zucchetti, Massimo, Taraboletti, Giulia

“…•The abnormal morphological and functional properties of the tumor vasculature are a major hindrance to the distribution and efficacy of antineoplastic…”
Get full text

Targeting angiogenesis with compounds from the extracellular matrix by Belotti, Dorina, Foglieni, Chiara, Resovi, Andrea, Giavazzi, Raffaella, Taraboletti, Giulia

“…The extracellular matrix (ECM) is the central element of a pericellular network of bioactive molecules. It orchestrates molecular interactions, availability…”
Get full text

Abstract 2981: Identification of circulating stroma-related biomarkers for pancreatic ductal adenocarcinoma by Resovi, Andrea, Porcu, Luca, Anastasia, Alessia, Allavena, Paola, Cappello, Paola, Falanga, Anna, Taraboletti, Giulia, Bani, Mariarosa, Belotti, Dorina, Giavazzi, Raffaella

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive epithelial malignancies characterized by a relevant amount of tumor stroma. It…”
Get full text

Integrating computational and chemical biology tools in the discovery of antiangiogenic small molecule ligands of FGF2 derived from endogenous inhibitors by Foglieni, Chiara, Pagano, Katiuscia, Lessi, Marco, Bugatti, Antonella, Moroni, Elisabetta, Pinessi, Denise, Resovi, Andrea, Ribatti, Domenico, Bertini, Sabrina, Ragona, Laura, Bellina, Fabio, Rusnati, Marco, Colombo, Giorgio, Taraboletti, Giulia

“…The FGFs/FGFRs system is a recognized actionable target for therapeutic approaches aimed at inhibiting tumor growth, angiogenesis, metastasis, and resistance…”
Get full text

Apelin Resistance Contributes to Muscle Loss during Cancer Cachexia in Mice by Re Cecconi, Andrea David, Barone, Mara, Forti, Mara, Lunardi, Martina, Cagnotto, Alfredo, Salmona, Mario, Olivari, Davide, Zentilin, Lorena, Resovi, Andrea, Persichitti, Perla, Belotti, Dorina, Palo, Federica, Takakura, Nobuyuki, Kidoya, Hiroyasu, Piccirillo, Rosanna

“…Cancer cachexia consists of dramatic body weight loss with rapid muscle depletion due to imbalanced protein homeostasis. We found that the mRNA levels of…”
Get full text

Abstract B12: Circulating stroma-related molecules as potential biomarkers for pancreatic ductal adenocarcinoma by Belotti, Dorina, Resovi, Andrea, Taraboletti, Giulia, Lawlor, Rita T., Scarpa, Aldo, Giavazzi, Raffaella

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with limited treatment options. Early diagnostic serological markers capable of…”
Get full text

Abstract 3857: Patient-derived tumor xenografts as pharmacological model of human pancreatic ductal adenocarcinoma by Anastasia, Alessia, Resovi, Andrea, Ghilardi, Carmen, Avigni, Roberta, Micotti, Edoardo, Minoli, Lucia, Scanziani, Eugenio, Corbellini, Carlo, Morandi, Eugenio, Belotti, Dorina, Giavazzi, Raffaella, Bani, MariaRosa

“…Abstract INTRODUCTION and AIM Pancreatic ductal adenocarcinoma is a lethal disease with an overall survival rate of 5% and a median survival time of less than…”
Get full text

Trabectedin and Lurbinectedin Extend Survival of Mice Bearing C26 Colon Adenocarcinoma, without Affecting Tumor Growth or Cachexia by Aquila, Giorgio, Re Cecconi, Andrea David, Forti, Mara, Frapolli, Roberta, Bello, Ezia, Novelli, Deborah, Russo, Ilaria, Licandro, Simonetta Andrea, Staszewsky, Lidia, Martinelli, Giulia Benedetta, Talamini, Laura, Pasetto, Laura, Resovi, Andrea, Giavazzi, Raffaella, Scanziani, Eugenio, Careccia, Giorgia, Vénéreau, Emilie, Masson, Serge, Latini, Roberto, D'Incalci, Maurizio, Piccirillo, Rosanna

“…Trabectedin (ET743) and lurbinectedin (PM01183) limit the production of inflammatory cytokines that are elevated during cancer cachexia. Mice carrying C26…”
Get full text

Expression of thrombospondin-1 by tumor cells in patient-derived ovarian carcinoma xenografts by Pinessi, Denise, Ostano, Paola, Borsotti, Patrizia, Bello, Ezia, Guffanti, Federica, Bizzaro, Francesca, Frapolli, Roberta, Bani, Maria Rosa, Chiorino, Giovanna, Taraboletti, Giulia, Resovi, Andrea

“…Thrombospondin-1 (TSP-1), a major regulator of cell interaction with the environment, is often deregulated in cancers, including ovarian carcinoma. Both the…”
Get more information

Inhibition of SIRT2 Potentiates the Anti-motility Activity of Taxanes: Implications for Antineoplastic Combination Therapies12 by Bonezzi, Katiuscia, Belotti, Dorina, North, Brian J, Ghilardi, Carmen, Borsotti, Patrizia, Resovi, Andrea, Ubezio, Paolo, Riva, Antonella, Giavazzi, Raffaella, Verdin, Eric, Taraboletti, Giulia

“…Taxanes are potent inhibitors of cell motility, a property implicated in their antiangiogenic and antimetastatic activity and unrelated to their…”
Get full text