Search Results - "Reshma, Rudraraju Srilakshmi"

Identification and development of benzoxazole derivatives as novel bacterial glutamate racemase inhibitors by Malapati, Prasanthi, Krishna, Vagolu Siva, Nallangi, Radhika, Srilakshmi, Rudraraju Reshma, Sriram, Dharmarajan

“…In the present study, we attempted to develop novel class of Mycobacterium tuberculosis (Mtb) inhibitors by exploring the pharmaceutically underexploited…”
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Synthesis, in vitro, and in vivo (Zebra fish) antitubercular activity of 7,8-dihydroquinolin-5(6H)-ylidenehydrazinecarbothioamides by Marvadi, Sandeep kumar, Krishna, Vagolu Siva, Surineni, Goverdhan, Srilakshmi Reshma, Rudraraju, Sridhar, Balasubramanian, Sriram, Dharmarajan, Kantevari, Srinivas

“…[Display omitted] •Twenty-two dihydroquinolinylidenehydrazinecarbothioamides 4a–v was synthesized.•Five compounds 4a, 4e, 4g, 4j and 4k were resulted as the…”
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Lead identification and optimization of bacterial glutamate racemase inhibitors by Malapati, Prasanthi, Siva Krishna, Vagolu, Nallangi, Radhika, Meda, Nikhila, Reshma Srilakshmi, Rudraraju, Sriram, Dharmarajan

“…[Display omitted] Mycobacterium tuberculosis glutamate racemase is an essential enzyme involved in peptidoglycan synthesis and conserved in most bacteria…”
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Synthesis and anti-mycobacterial activity of 4-(4-phenyl-1H-1,2,3-triazol-1-yl)salicylhydrazones: revitalizing an old drug by Abdu-Allah, Hajjaj H. M., Youssif, Bahaa G. M., Abdelrahman, Mostafa H., Abdel-Hamid, Mohammed K., Reshma, Rudraraju Srilakshmi, Yogeeswari, Perumal, Aboul-Fadl, Tarek, Sriram, Dharmarajan

“…The antitubercular drug; para -aminosalicylic acid (PAS) was used as the core scaffold for the design of a series of 1 H -1,2,3-triazolylsalicylhydrazones upon…”
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Design and development of novel inhibitors for the treatment of latent tuberculosis by Reshma, Rudraraju Srilakshmi, Yogeeswari, Perumal, Sriram, Dharmarajan

“…Abstract Objective/background “The captain of all these men of death”, is the apt sobriquet for the age-old disease tuberculosis (TB). Despite the availability…”
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Engineering another class of anti-tubercular lead: Hit to lead optimization of an intriguing class of gyrase ATPase inhibitors by Jeankumar, Variam Ullas, Reshma, Rudraraju Srilakshmi, Vats, Rahul, Janupally, Renuka, Saxena, Shalini, Yogeeswari, Perumal, Sriram, Dharmarajan

“…A structure based medium throughput virtual screening campaign of BITS-Pilani in house chemical library to identify novel binders of Mycobacterium tuberculosis…”
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Synthesis and evaluation of 4′,5′-dihydrospiro[piperidine-4,7′-thieno[2,3-c]pyran] analogues against both active and dormant Mycobacterium tuberculosis by Alluri, Kiran Kumar, Reshma, Rudraraju Srilakshmi, Suraparaju, Raghuram, Gottapu, Suryanarayana, Sriram, Dharmarajan

“…[Display omitted] Need for new drugs to fight against tuberculosis (TB) is increasing day by day. In the present work we have taken a spiro compound (GSK…”
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A robust synthesis of functionalized 2H-indazoles via solid state melt reaction (SSMR) and their anti-tubercular activity by Vidyacharan, Shinde, Adhikari, Chandan, Krishna, Vagolu Siva, Reshma, Rudraraju Srilakshmi, Sriram, Dharmarajan, Sharada, Duddu S.

“…[Display omitted] A facile and convenient approach has been developed for the synthesis of functionalized indazoles via solid state melt reaction using easily…”
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Engineering of Ancestors as a Tool to Elucidate Structure, Mechanism, and Specificity of Extant Terpene Cyclase by Schriever, Karen, Saenz-Mendez, Patricia, Rudraraju, Reshma Srilakshmi, Hendrikse, Natalie M, Hudson, Elton P, Biundo, Antonino, Schnell, Robert, Syrén, Per-Olof

“…Structural information is crucial for understanding catalytic mechanisms and to guide enzyme engineering efforts of biocatalysts, such as terpene cyclases…”
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Lead derivatization of ethyl 6-bromo-2-((dimethylamino)methyl)-5-hydroxy-1-phenyl-1H-indole-3-carboxylate and 5-bromo-2-(thiophene-2-carboxamido) benzoic acid as FabG inhibitors targeting ESKAPE pathogens by Varakala, Saiprasad Dasugari, Reshma, Rudraraju Srilakshmi, Schnell, Robert, Dharmarajan, Sriram

“…Our previous studies on FabG have identified two compounds 5-bromo-2-(thiophene-2-carboxamido) benzoic acid (A) and ethyl…”
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A FabG inhibitor targeting an allosteric binding site inhibits several orthologs from Gram-negative ESKAPE pathogens by Vella, Peter, Rudraraju, Reshma Srilakshmi, Lundbäck, Thomas, Axelsson, Hanna, Almqvist, Helena, Vallin, Michaela, Schneider, Gunter, Schnell, Robert

“…[Display omitted] •FabG from the bacterial fatty acid biosynthesis (FAS-II) system is a potential target for antibiotics.•Inhibitors were identified by…”
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Mycobacterium tuberculosis lysine-ɛ-aminotransferase a potential target in dormancy: Benzothiazole based inhibitors by Reshma, Rudraraju Srilakshmi, Jeankumar, Variam Ullas, Kapoor, Nidhi, Saxena, Shalini, Bobesh, Karyakulam Andrews, Vachaspathy, Astakala Rishi, Kolattukudy, Pappachan E., Sriram, Dharmarajan

“…[Display omitted] MTB lysine-ɛ-aminotransferase (LAT) was found to play a crucial role in persistence and antibiotic tolerance. LAT serves as a potential…”
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Design and development of new class of Mycobacterium tuberculosis l-alanine dehydrogenase inhibitors by Reshma, Rudraraju Srilakshmi, Saxena, Shalini, Bobesh, Karyakulam Andrews, Jeankumar, Variam Ullas, Gunda, Saritha, Yogeeswari, Perumal, Sriram, Dharmarajan

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Replacement of cardiotoxic aminopiperidine linker with piperazine moiety reduces cardiotoxicity? Mycobacterium tuberculosis novel bacterial topoisomerase inhibitors by Bobesh, Karyakulam Andrews, Renuka, Janupally, Srilakshmi, Rudraraju Reshma, Yellanki, Swapna, Kulkarni, Pushkar, Yogeeswari, Perumal, Sriram, Dharmarajan

“…This kind of compounds retains good potency and showed reduced cardiotoxicity compared to aminopiperidines. [Display omitted] Recently numerous…”
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Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis by Brunner, Katharina, Maric, Selma, Reshma, Rudraraju Srilakshmi, Almqvist, Helena, Seashore-Ludlow, Brinton, Gustavsson, Anna-Lena, Poyraz, Ömer, Yogeeswari, Perumal, Lundbäck, Thomas, Vallin, Michaela, Sriram, Dharmarajan, Schnell, Robert, Schneider, Gunter

“…Cysteine is an important amino acid in the redox defense of Mycobacterium tuberculosis, primarily as a building block of mycothiol. Genetic studies have…”
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A robust synthesis of functionalized 2 H -indazoles via solid state melt reaction (SSMR) and their anti-tubercular activity by Vidyacharan, Shinde, Adhikari, Chandan, Krishna, Vagolu Siva, Reshma, Rudraraju Srilakshmi, Sriram, Dharmarajan, Sharada, Duddu S.

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Profiling of in vitro activities of urea-based inhibitors against cysteine synthases from Mycobacterium tuberculosis by Brunner, Katharina, Steiner, Eva Maria, Reshma, Rudraraju Srilakshmi, Sriram, Dharmarajan, Schnell, Robert, Schneider, Gunter

“…[Display omitted] CysK1 and CysK2 are two members of the cysteine/S-sulfocysteine synthase family in Mycobacterium tuberculosis, responsible for the de novo…”
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Enabling the (3 + 2) cycloaddition reaction in assembling newer anti-tubercular lead acting through the inhibition of the gyrase ATPase domain: lead optimization and structure activity profiling by Jeankumar, Variam Ullas, Reshma, Rudraraju Srilakshmi, Janupally, Renuka, Saxena, Shalini, Sridevi, Jonnalagadda Padma, Medapi, Brahmam, Kulkarni, Pushkar, Yogeeswari, Perumal, Sriram, Dharmarajan

“…DNA gyrase, the sole type II topoisomerase present in Mycobacterium tuberculosis, is absent in humans and is a well validated target for anti-tubercular drug…”
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Design and development of new class of Mycobacterium tuberculosisl-alanine dehydrogenase inhibitors by Reshma, Rudraraju Srilakshmi, Saxena, Shalini, Bobesh, Karyakulam Andrews, Jeankumar, Variam Ullas, Gunda, Saritha, Yogeeswari, Perumal, Sriram, Dharmarajan

“…[Display omitted] Mycobacterium tuberculosisl-alanine dehydrogenase (MTB l-AlaDH) is one of the important drug targets for treating latent/persistent…”
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Structure-Guided Discovery of Antitubercular Agents That Target the Gyrase ATPase Domain by Jeankumar, Variam U., Saxena, Shalini, Vats, Rahul, Reshma, Rudraraju Srilakshmi, Janupally, Renuka, Kulkarni, Pushkar, Yogeeswari, Perumal, Sriram, Dharmarajan

“…In this study we explored the pharmaceutically underexploited ATPase domain of DNA gyrase (GyrB) as a potential platform for developing novel agents that…”
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