Search Results - "Resh, Marilyn D."

Trafficking and signaling by fatty-acylated and prenylated proteins by Resh, Marilyn D

“…A wide variety of signaling proteins are modified by covalently linked fatty acids and/or prenyl groups. These hydrophobic moieties, which include myristate,…”
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Specification of positional identity in forebrain organoids by Cederquist, Gustav Y., Asciolla, James J., Tchieu, Jason, Walsh, Ryan M., Cornacchia, Daniela, Resh, Marilyn D., Studer, Lorenz

“…Human brain organoids generated with current technologies recapitulate histological features of the human brain, but they lack a reproducible topographic…”
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Myristoylation and Membrane Binding Regulate c-Src Stability and Kinase Activity by Patwardhan, Parag, Resh, Marilyn D.

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Palmitoylation of Hedgehog proteins by Hedgehog acyltransferase: roles in signalling and disease by Resh, Marilyn D

“…Hedgehog acyltransferase (Hhat), a member of the membrane-bound -acyltransferase (MBOAT) family, catalyses the covalent attachment of palmitate to the…”
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Identification of Key Residues and Regions Important for Porcupine-mediated Wnt Acylation by Rios-Esteves, Jessica, Haugen, Brittany, Resh, Marilyn D.

“…Wnts comprise a family of lipid-modified, secreted signaling proteins that control embryogenesis, as well as tissue homeostasis in adults. Post-translational…”
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Hhat Is a Palmitoylacyltransferase with Specificity for N-Palmitoylation of Sonic Hedgehog by Buglino, John A., Resh, Marilyn D.

“…Palmitoylation of Sonic Hedgehog (Shh) is critical for effective long- and short-range signaling. Genetic screens uncovered a potential…”
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Open Biology: overview for special issue on dynamics of protein fatty acylation by Resh, Marilyn D

“…Fatty acylation is a widespread form of protein modification that occurs on specific intracellular and secreted proteins. Beyond increasing hydrophobicity and…”
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Use of analogs and inhibitors to study the functional significance of protein palmitoylation by Resh, Marilyn D.

“…Covalent attachment of palmitate to proteins is a post-translational modification that exerts diverse effects on protein localization and function. The three…”
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Hedgehog Acyltransferase Promotes Uptake of Palmitoyl-CoA across the Endoplasmic Reticulum Membrane by Asciolla, James J., Resh, Marilyn D.

“…Attachment of palmitate to the N terminus of Sonic hedgehog (Shh) is essential for Shh signaling. Shh palmitoylation is catalyzed on the luminal side of the…”
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Fatty acylation of proteins: The long and the short of it by Resh, Marilyn D.

“…Long, short and medium chain fatty acids are covalently attached to hundreds of proteins. Each fatty acid confers distinct biochemical properties, enabling…”
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Stearoyl CoA Desaturase Is Required to Produce Active, Lipid-Modified Wnt Proteins by Rios-Esteves, Jessica, Resh, Marilyn D.

“…Wnt proteins contain palmitoleic acid, an unusual lipid modification. Production of an active Wnt signal requires the acyltransferase Porcupine and depends on…”
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Identification of N-terminal Residues of Sonic Hedgehog Important for Palmitoylation by Hedgehog Acyltransferase by Hardy, Rayshonda Y., Resh, Marilyn D.

“…Sonic Hedgehog (Shh) is a secreted morphogen that regulates embryonic development. After removal of the signal peptide, Shh is processed to the mature, active…”
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Identification of conserved regions and residues within Hedgehog acyltransferase critical for palmitoylation of Sonic Hedgehog by Buglino, John A, Resh, Marilyn D

“…Sonic hedgehog (Shh) is a palmitoylated protein that plays key roles in mammalian development and human cancers. Palmitoylation of Shh is required for…”
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Covalent lipid modifications of proteins by Resh, Marilyn D.

“…Attachment of lipophilic groups is a widespread modification that occurs on nearly 1,000 proteins of diverse structure and function. At least five different…”
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Membrane targeting of lipid modified signal transduction proteins by Resh, Marilyn D

“…Covalent attachment of lipophilic moieties to proteins influences interaction with membranes and membrane microdomains, as well as signal transduction. The…”
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Identification of an Intracellular Trafficking and Assembly Pathway for HIV‐1 Gag by Perlman, Mira, Resh, Marilyn D.

“…Retroviral Gag proteins are membrane‐bound polyproteins that are necessary and sufficient for virus‐like particle (VLP) formation. It is not known how Gag…”
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Signaling from Integrins to Fyn to Rho Family GTPases Regulates Morphologic Differentiation of Oligodendrocytes by Liang, Xiquan, Draghi, Nicole A, Resh, Marilyn D

“…Differentiation of oligodendrocyte progenitor cells requires activation of the Src family kinase Fyn. The signals that are upstream and downstream of Fyn in…”
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Palmitoylation of proteins in cancer by Resh, Marilyn D

“…Post-translational modification of proteins by attachment of palmitate serves as a mechanism to regulate protein localization and function in both normal and…”
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Cholesterol Depletion from the Plasma Membrane Triggers Ligand-independent Activation of the Epidermal Growth Factor Receptor by Chen, Xu, Resh, Marilyn D.

“…We recently demonstrated that depletion of plasma membrane cholesterol with methyl-β-cyclodextrin (MβCD) caused activation of MAPK (Chen, X., and Resh, M. D…”
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Annexin 2 Is Not Required for Human Immunodeficiency Virus Type 1 Particle Production but Plays a Cell Type-Dependent Role in Regulating Infectivity by TIA RAI, MOSOIAN, Arevik, RESH, Marilyn D

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