Search Results - "Reschly, Erica J"

Challenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXR by Ekins, Sean, Kortagere, Sandhya, Iyer, Manisha, Reschly, Erica J, Lill, Markus A, Redinbo, Matthew R, Krasowski, Matthew D

“…Transcriptional regulation of some genes involved in xenobiotic detoxification and apoptosis is performed via the human pregnane X receptor (PXR) which in turn…”
Get full text

Evolution of pharmacologic specificity in the pregnane X receptor by Ekins, Sean, Reschly, Erica J, Hagey, Lee R, Krasowski, Matthew D

“…The pregnane X receptor (PXR) shows the highest degree of cross-species sequence diversity of any of the vertebrate nuclear hormone receptors. In this study,…”
Get full text

Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sites by Ekins, Sean, Chang, Cheng, Mani, Sridhar, Krasowski, Matthew D, Reschly, Erica J, Iyer, Manisha, Kholodovych, Vladyslav, Ai, Ni, Welsh, William J, Sinz, Michael, Swaan, Peter W, Patel, Rachana, Bachmann, Kenneth

“…The pregnane X receptor (PXR) is an important transcriptional regulator of the expression of xenobiotic metabolism and transporter genes. The receptor is…”
Get more information

Evolution of the bile salt nuclear receptor FXR in vertebrates by Reschly, Erica J, Ai, Ni, Ekins, Sean, Welsh, William J, Hagey, Lee R, Hofmann, Alan F, Krasowski, Matthew D

“…Bile salts, the major end metabolites of cholesterol, vary significantly in structure across vertebrate species, suggesting that nuclear receptors binding…”
Get full text

Evaluation of Computational Docking to Identify Pregnane X Receptor Agonists in the ToxCast Database by Kortagere, Sandhya, Krasowski, Matthew D., Reschly, Erica J., Venkatesh, Madhukumar, Mani, Sridhar, Ekins, Sean

“…Background: The pregnane X receptor (PXR) is a key transcriptional regulator of many genes [e.g., cytochrome P450s (CYP2C9, CYP3A4, CYP2B6), MDR1] involved in…”
Get full text

Functional evolution of the vitamin D and pregnane X receptors by Reschly, Erica J, Bainy, Afonso Celso Dias, Mattos, Jaco Joaquim, Hagey, Lee R, Bahary, Nathan, Mada, Sripal R, Ou, Junhai, Venkataramanan, Raman, Krasowski, Matthew D

“…The vitamin D receptor (VDR) and pregnane X receptor (PXR) are nuclear hormone receptors of the NR1I subfamily that show contrasting patterns of cross-species…”
Get full text

Machine Learning Methods and Docking for Predicting Human Pregnane X Receptor Activation by Khandelwal, Akash, Krasowski, Matthew D, Reschly, Erica J, Sinz, Michael W, Swaan, Peter W, Ekins, Sean

“…The pregnane X receptor (PXR) regulates the expression of genes involved in xenobiotic metabolism and transport. In vitro methods to screen for PXR agonists…”
Get full text

Ligand specificity and evolution of liver X receptors by Reschly, Erica J., Ai, Ni, Welsh, William J., Ekins, Sean, Hagey, Lee R., Krasowski, Matthew D.

“…Liver X receptors (LXRs) are key regulators of lipid and cholesterol metabolism in mammals. Little is known, however, about the function and evolution of LXRs…”
Get full text

The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species by Krasowski, Matthew D, Ai, Ni, Hagey, Lee R, Kollitz, Erin M, Kullman, Seth W, Reschly, Erica J, Ekins, Sean

“…The farnesoid X receptor (FXR), pregnane X receptor (PXR), and vitamin D receptor (VDR) are three closely related nuclear hormone receptors in the NR1H and 1I…”
Get full text

Functional evolution of the pregnane X receptor by Iyer, Manisha, Reschly, Erica J, Krasowski, Matthew D

“…The pregnane X receptor (PXR; NR1I2) is a nuclear hormone receptor (NR) that transcriptionally regulates genes encoding transporters and drug-metabolising…”
Get more information

Intrinsic Disorder in Nuclear Hormone Receptors by Krasowski, Matthew D, Reschly, Erica J, Ekins, Sean

“…Many proteins possess intrinsic disorder (ID) and lack a rigid three-dimensional structure in at least part of their sequence. ID has been hypothesized to…”
Get full text

Activation of a tunicate (Ciona intestinalis) xenobiotic receptor orthologue by both natural toxins and synthetic toxicants by Fidler, Andrew E., Holland, Patrick T., Reschly, Erica J., Ekins, Sean, Krasowski, Matthew D.

“…Vertebrate xenobiotic receptors are ligand-activated nuclear receptors (NRs) that bind exogenous biologically active chemicals before activating the…”
Get full text

Notch1 co-opts lymphoid enhancer factor 1 for survival of murine T-cell lymphomas by Spaulding, Christina, Reschly, Erica J., Zagort, Derek E., Yashiro-Ohtani, Yumi, Beverly, Levi J., Capobianco, Anthony, Pear, Warren S., Kee, Barbara L.

“…Oncogenic Notch1 mutations are found in most T-lineage acute lymphoblastic leukemias in humans and T-cell lymphomas in mice. However, the mechanism by which…”
Get full text

Notch1 promotes survival of E2A-deficient T cell lymphomas through pre–T cell receptor–dependent and –independent mechanisms by Reschly, Erica J., Spaulding, Christina, Vilimas, Tomas, Graham, W. Vallen, Brumbaugh, Rachel L., Aifantis, Iannis, Pear, Warren S., Kee, Barbara L.

“…Loss of E2A transcription factor activity or activation of the intracellular form of Notch1 (ICN) leads to the development of leukemia or lymphoma in humans or…”
Get full text

Evolution of the bile salt nuclear receptor FXR in vertebratess by Reschly, Erica J., Ai, Ni, Ekins, Sean, Welsh, William J., Hagey, Lee R., Hofmann, Alan F., Krasowski, Matthew D.

“…Bile salts, the major end metabolites of cholesterol, vary significantly in structure across vertebrate species, suggesting that nuclear receptors binding…”
Get full text

Apolipoprotein A-I α-Helices 7 and 8 Modulate High Density Lipoprotein Subclass Distribution by Reschly, Erica J., Sorci-Thomas, Mary G., Davidson, W. Sean, Meredith, Stephen C., Reardon, Catherine A., Getz, Godfrey S.

“…Mice have a monodisperse high density lipoprotein (HDL) profile, whereas humans have two major subfractions designated HDL2 and HDL3. Human apoA-I transgenic…”
Get full text

Sterol Carrier Protein-2 Overexpression Enhances Sterol Cycling and Inhibits Cholesterol Ester Synthesis and High Density Lipoprotein Cholesterol Secretion by Baum, Charles L., Reschly, Erica J., Gayen, Apurba K., Groh, Margaret E., Schadick, Kevin

“…Recent data indicate that sterol carrier protein-2 (SCP-2) functions in the rapid movement of newly synthesized cholesterol to the plasma membrane (Puglielli,…”
Get full text

Challenges Predicting Ligand-Receptor Interactions of Promiscuous Proteins: The Nuclear Receptor PXR: e1000594 by Ekins, Sean, Kortagere, Sandhya, Iyer, Manisha, Reschly, Erica J, Lill, Markus A, Redinbo, Matthew R, Krasowski, Matthew D

“…Transcriptional regulation of some genes involved in xenobiotic detoxification and apoptosis is performed via the human pregnane X receptor (PXR) which in turn…”
Get full text

Notch 1 co-opts lymphoid enhancer factor 1 for survival of murine T-cell lymphomas. Commenary by GOUNARI, Fotini, DOSE, Marei, SPAULDING, Christina, RESCHLY, Erica J, ZAGORT, Derek E, YASHIRO-OHTANI, Yumi, BEVERLY, Levi J, CAPOBIANCO, Anthony, PEAR, Warren S, KEEL, Barbara L

Get full text

Apolipoprotein A-I α-Helices 7 and 8 Modulate High Density Lipoprotein Subclass Distribution by Erica J. Reschly, Mary G. Sorci-Thomas, W. Sean Davidson, Stephen C. Meredith, Catherine A. Reardon, Godfrey S. Getz

“…Mice have a monodisperse high density lipoprotein (HDL) profile, whereas humans have two major subfractions designated HDL 2 and HDL 3 . Human apoA-I…”
Get full text