Search Results - "Reschke, Melanie"

Polyglycerol and Poly(ethylene glycol) exhibit different effects on pharmacokinetics and antibody generation when grafted to nanoparticle surfaces by Shin, Kwangsoo, Suh, Hee-Won, Grundler, Julian, Lynn, Anna Y., Pothupitiya, Jinal U., Moscato, Zoe M., Reschke, Melanie, Bracaglia, Laura G., Piotrowski-Daspit, Alexandra S., Saltzman, W. Mark

“…Poly(ethylene glycol) (PEG) is widely employed for passivating nanoparticle (NP) surfaces to prolong blood circulation and enhance localization of NPs to…”
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Multifunctionalization of cetuximab with bioorthogonal chemistries and parallel EGFR profiling of cell-lines using imaging, FACS and immunoprecipitation approaches by Reschke, Melanie L., Uprety, Rajendra, Bodhinayake, Imithri, Banu, Matei, Boockvar, John A., Sauve, Anthony A.

“…The ability to derivatize antibodies is currently limited by the chemical structure of antibodies as polypeptides. Modern methods of bioorthogonal and…”
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A digital pathology tool for quantification of color features in histologic specimens by Reschke, Melanie, DiRito, Jenna R., Stern, David, Day, Wesley, Plebanek, Natalie, Harris, Matthew, Hosgood, Sarah A., Nicholson, Michael L., Haakinson, Danielle J., Zhang, Xuchen, Mehal, Wajahat Z., Ouyang, Xinshou, Pober, Jordan S., Saltzman, W. Mark, Tietjen, Gregory T.

“…In preclinical research, histological analysis of tissue samples is often limited to qualitative or semiquantitative scoring assessments. The reliability of…”
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Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses by Mao, Tianyang, Israelow, Benjamin, Peña-Hernández, Mario A, Suberi, Alexandra, Zhou, Liqun, Luyten, Sophia, Reschke, Melanie, Dong, Huiping, Homer, Robert J, Saltzman, W Mark, Iwasaki, Akiko

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has highlighted the need for vaccines that not only prevent disease but also prevent…”
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Polymer nanoparticles deliver mRNA to the lung for mucosal vaccination by Suberi, Alexandra, Grun, Molly K, Mao, Tianyang, Israelow, Benjamin, Reschke, Melanie, Grundler, Julian, Akhtar, Laiba, Lee, Teresa, Shin, Kwangsoo, Piotrowski-Daspit, Alexandra S, Homer, Robert J, Iwasaki, Akiko, Suh, Hee-Won, Saltzman, W Mark

“…An inhalable platform for messenger RNA (mRNA) therapeutics would enable minimally invasive and lung-targeted delivery for a host of pulmonary diseases…”
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Nucleic Acid Delivery to the Vascular Endothelium by Reschke, Melanie, Piotrowski-Daspit, Alexandra S., Pober, Jordan S., Saltzman, W. Mark

“…This Review examines the state-of-the-art in the delivery of nucleic acid therapies that are directed to the vascular endothelium. First, we review the most…”
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Lysis of cold‐storage‐induced microvascular obstructions for ex vivo revitalization of marginal human kidneys by DiRito, Jenna R., Hosgood, Sarah A., Reschke, Melanie, Albert, Claire, Bracaglia, Laura G., Ferdinand, John R., Stewart, Benjamin J., Edwards, Christopher M., Vaish, Anand G., Thiru, Sathia, Mulligan, David C., Haakinson, Danielle J., Clatworthy, Menna R., Saltzman, W. Mark, Pober, Jordan S., Nicholson, Michael L., Tietjen, Gregory T.

“…Thousands of kidneys from higher‐risk donors are discarded annually because of the increased likelihood of complications posttransplant. Given the severe organ…”
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Cross-platform analysis reveals cellular and molecular landscape of glioblastoma invasion by Chen, Ann T, Xiao, Yang, Tang, Xiangjun, Baqri, Mehdi, Gao, Xingchun, Reschke, Melanie, Sheu, Wendy C, Long, Gretchen, Zhou, Yu, Deng, Gang, Zhang, Shenqi, Deng, Yanxiang, Bai, Zhiliang, Kim, Dongjoo, Huttner, Anita, Kunes, Russell, Günel, Murat, Moliterno, Jennifer, Saltzman, W Mark, Fan, Rong, Zhou, Jiangbing

“…Abstract Background Improved treatment of glioblastoma (GBM) needs to address tumor invasion, a hallmark of the disease that remains poorly understood. In this…”
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Progenitor-derived human endothelial cells evade alloimmunity by CRISPR/Cas9-mediated complete ablation of MHC expression by Merola, Jonathan, Reschke, Melanie, Pierce, Richard W, Qin, Lingfeng, Spindler, Susann, Baltazar, Tania, Manes, Thomas D, Lopez-Giraldez, Francesc, Li, Guangxin, Bracaglia, Laura G, Xie, Catherine, Kirkiles-Smith, Nancy, Saltzman, W Mark, Tietjen, Gregory T, Tellides, George, Pober, Jordan S

“…Tissue engineering may address organ shortages currently limiting clinical transplantation. Off-the-shelf engineered vascularized organs will likely use…”
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Targeted Nucleic Acid Delivery to the Endothelium by Reschke Horwitz, Melanie Lynn

“…The human endothelium extends throughout nearly all tissues in the body, and has an estimated total surface area of up to seven thousand square meters [1]…”
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