Search Results - "Resch, Michael G."
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Glycosylated linkers in multimodular lignocellulose-degrading enzymes dynamically bind to cellulose
Published in Proceedings of the National Academy of Sciences - PNAS (03-09-2013)“…Plant cell-wall polysaccharides represent a vast source of food in nature. To depolymerize polysaccharides to soluble sugars, many organisms use…”
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Predicting Enzyme Adsorption to Lignin Films by Calculating Enzyme Surface Hydrophobicity
Published in The Journal of biological chemistry (25-07-2014)“…The inhibitory action of lignin on cellulase cocktails is a major challenge to the biological saccharification of plant cell wall polysaccharides. Although the…”
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Specificity of O-glycosylation in enhancing the stability and cellulose binding affinity of Family 1 carbohydrate-binding modules
Published in Proceedings of the National Academy of Sciences - PNAS (27-05-2014)“…The majority of biological turnover of lignocellulosic biomass in nature is conducted by fungi, which commonly use Family 1 carbohydrate-binding modules (CBMs)…”
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Replacement of histone H3 with CENP-A directs global nucleosome array condensation and loosening of nucleosome superhelical termini
Published in Proceedings of the National Academy of Sciences - PNAS (04-10-2011)“…Centromere protein A (CENP-A) is a histone H3 variant that marks centromere location on the chromosome. To study the subunit structure and folding of human…”
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The O-Glycosylated Linker from the Trichoderma reesei Family 7 Cellulase Is a Flexible, Disordered Protein
Published in Biophysical journal (01-12-2010)“…Fungi and bacteria secrete glycoprotein cocktails to deconstruct cellulose. Cellulose-degrading enzymes (cellulases) are often modular, with catalytic domains…”
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Reductive Catalytic Fractionation of Corn Stover Lignin
Published in ACS sustainable chemistry & engineering (05-12-2016)“…Reductive catalytic fractionation (RCF) has emerged as an effective biomass pretreatment strategy to depolymerize lignin into tractable fragments in high…”
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Mechanisms employed by cellulase systems to gain access through the complex architecture of lignocellulosic substrates
Published in Current opinion in chemical biology (01-12-2015)“…•Novel imaging and sample preparation reveales enzymatic deconstruction mechanisms.•Disrupting lignin and cellulose crystallinity enhances enzymatic…”
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Revealing Nature's Cellulase Diversity: The Digestion Mechanism of Caldicellulosiruptor bescii CelA
Published in Science (American Association for the Advancement of Science) (20-12-2013)“…Most fungi and bacteria degrade plant cell walls by secreting free, complementary enzymes that hydrolyze cellulose; however, some bacteria use large enzymatic…”
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Using Incremental Changes to Convert Lignocellulosic Feedstocks to Cellulosic Ethanol
Published in Frontiers in energy research (21-03-2022)“…One billion tons of biomass feedstocks have been identified for the production of renewable biofuels and biochemicals. This is one of the key carbon feedstocks…”
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Engineered yeast tolerance enables efficient production from toxified lignocellulosic feedstocks
Published in Science advances (25-06-2021)“…Rationally engineered tolerance enables broadly efficient lignocellulosic fermentation of diverse feedstocks and bioproducts. Lignocellulosic biomass remains…”
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Alkaline Pretreatment of Switchgrass
Published in ACS sustainable chemistry & engineering (06-07-2015)“…Alkaline pretreatment using sodium hydroxide offers a means to extract lignin and acetate from lignocellulosic biomass, in turn enabling higher enzymatic…”
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O‐glycosylation effects on family 1 carbohydrate‐binding module solution structures
Published in The FEBS journal (01-11-2015)“…Family 1 carbohydrate‐binding modules (CBMs) are ubiquitous components of multimodular fungal enzymes that degrade plant cell wall polysaccharides and bind…”
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Understanding Limitations in Electrochemical Conversion to CO at Low CO 2 Concentrations
Published in ACS energy letters (12-07-2024)“…Low-temperature electrochemical CO reduction has demonstrated high selectivity for CO when devices are operated with pure CO streams. However, there is…”
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Multiscale Characterization of Lignocellulosic Biomass Variability and Its Implications to Preprocessing and Conversion: a Case Study for Corn Stover
Published in ACS sustainable chemistry & engineering (02-03-2020)“…Feedstock variability that originates from biomass production and field conditions propagates through the value chain, posing a significant challenge to the…”
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Throughput, Reliability, and Yields of a Pilot-Scale Conversion Process for Production of Fermentable Sugars from Lignocellulosic Biomass: A Study on Feedstock Ash and Moisture
Published in ACS sustainable chemistry & engineering (03-02-2020)“…Early lignocellulosic biorefineries have been plagued with numerous issues that involve feedstock handling problems and variations in conversion efficacy that…”
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Interrelationships between cellulase activity and cellulose particle morphology
Published in Cellulose (London) (01-08-2016)“…It is well documented that the enzymatic hydrolysis of cellulose follows a reaction pattern where an initial phase of relatively high activity is followed by a…”
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Impacts of Inorganic Material (Total Ash) on Surface Energy, Wettability, and Cohesion of Corn Stover
Published in ACS sustainable chemistry & engineering (03-02-2020)“…The impacts and variability of inorganic material (measured as total ash) on surface area, surface energy, wettability, and cohesion of corn stover samples…”
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Understanding Limitations in Electrochemical Conversion to CO at Low CO2 Concentrations
Published in ACS energy letters (24-06-2024)“…Low-temperature electrochemical CO2 reduction has demonstrated high selectivity for CO when devices are operated with pure CO2 streams. However, there is…”
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Molecular-scale features that govern the effects of O -glycosylation on a carbohydrate-binding module
Published in Chemical science (Cambridge) (01-01-2015)“…Protein glycosylation is a ubiquitous post-translational modification in all kingdoms of life. Despite its importance in molecular and cellular biology, the…”
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