Search Results - "Resar, Linda"

Taking the STING out of acute myeloid leukemia through macrophage-mediated phagocytosis by Dalton, William Brian, Ghiaur, Gabriel, Resar, Linda Ms

“…Macrophages within the bone marrow (BM) microenvironment take on unexpected roles in acute myeloid leukemia (AML) as reported by Moore and colleagues in this…”
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The High Mobility Group A1 Gene: Transforming Inflammatory Signals into Cancer? by RESAR, Linda M. S

“…High mobility group A1 (HMGA1) is highly expressed during embryogenesis and in poorly differentiated cancers, and high levels portend a poor prognosis in some…”
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Characterizing metabolic changes in human colorectal cancer by Williams, Michael D., Zhang, Xing, Park, Jeong-Jin, Siems, William F., Gang, David R., Resar, Linda M. S., Reeves, Raymond, Hill, Herbert H.

“…Colorectal cancer (CRC) remains a leading cause of cancer death worldwide, despite the fact that it is a curable disease when diagnosed early. The development…”
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HMGA1: a master regulator of tumor progression in triple-negative breast cancer cells by Shah, Sandeep N, Cope, Leslie, Poh, Weijie, Belton, Amy, Roy, Sujayita, Talbot, Jr, C Conover, Sukumar, Saraswati, Huso, David L, Resar, Linda M S

“…Emerging evidence suggests that tumor cells metastasize by co-opting stem cell transcriptional networks, although the molecular underpinnings of this process…”
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HMGA1 induces intestinal polyposis in transgenic mice and drives tumor progression and stem cell properties in colon cancer cells by Belton, Amy, Gabrovsky, Alexander, Bae, Young Kyung, Reeves, Ray, Iacobuzio-Donahue, Christine, Huso, David L, Resar, Linda M S

“…Although metastatic colon cancer is a leading cause of cancer death worldwide, the molecular mechanisms that enable colon cancer cells to metastasize remain…”
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Management and clinical outcomes for patients with gastrointestinal bleeding who decline transfusion by Asiedu, Jessica O, Thomas, Ananda J, Cruz, Nicolas C, Nicholson, Ryan, Resar, Linda M. S, Khashab, Mouen, Frank, Steven M

“…Background The national blood shortage and growing patient population who decline blood transfusions have created the need for bloodless medicine initiatives…”
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A novel method of data analysis for utilization of red blood cell transfusion by Frank, Steven M., Resar, Linda M.S., Rothschild, James A., Dackiw, Elizabeth A., Savage, Will J., Ness, Paul M.

“…Background A necessary component of an effective blood management program is the accurate and comprehensive collection and analysis of blood utilization data…”
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HMGA1 reprograms somatic cells into pluripotent stem cells by inducing stem cell transcriptional networks by Shah, Sandeep N, Kerr, Candace, Cope, Leslie, Zambidis, Elias, Liu, Cyndi, Hillion, Joelle, Belton, Amy, Huso, David L, Resar, Linda M S

“…Although recent studies have identified genes expressed in human embryonic stem cells (hESCs) that induce pluripotency, the molecular underpinnings of normal…”
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Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures by Chou, Bin-Kuan, Mali, Prashant, Huang, Xiaosong, Ye, Zhaohui, Dowey, Sarah N, Resar, Linda MS, Zou, Chunlin, Zhang, Y Alex, Tong, Jay, Cheng, Linzhao

“…To identify accessible and permissive human cell types for efficient derivation of induced pluripotent stem cells （iPSCs）, we investigated epigenetic and gene…”
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Getting into good trouble: Black lives matter and Black professors matter by Chisholm, Briyana, Neptune, Enid R, Golden, Sherita Hill, Resar, Linda Ms

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Doubling up on function: dual-specificity tyrosine-regulated kinase 1A (DYRK1A) in B cell acute lymphoblastic leukemia by Kim, Jung-Hyun, Li, Liping, Resar, Linda Ms

“…DYRK1A, the dual-specificity kinase, is again doubling up on function, as reported by Bhansali, Rammohan, and colleagues in this issue of the JCI. DYRK1A is an…”
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Perioperative Management of Patients for Whom Transfusion Is Not an Option by Guinn, Nicole R., Resar, Linda M. S., Frank, Steven M.

“…This article reviews the management of patients requesting or requiring surgery without transfusion, including patient identification and informed consent,…”
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Equity and diversity in academic medicine: a perspective from the JCI editors by Resar, Linda Ms, Jaffee, Elizabeth M, Armanios, Mary, Jackson, Sarah, Azad, Nilofer S, Horton, Maureen R, Kaplan, Mariana J, Laiho, Marikki, Maus, Marcela V, Sumner, Charlotte J, Wheelan, Sarah J, Wills-Karp, Marsha

“…The #MeToo movement has taken on sexual harassment in the workplace and served to inform the world that these unacceptable and illegal acts have become…”
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HMGA1 drives stem cell, inflammatory pathway, and cell cycle progression genes during lymphoid tumorigenesis by Schuldenfrei, Andrew, Belton, Amy, Kowalski, Jeanne, Talbot, Jr, C Conover, Di Cello, Francescopaolo, Poh, Weijie, Tsai, Hua-Ling, Shah, Sandeep N, Huso, Tait H, Huso, David L, Resar, Linda M S

“…Although the high mobility group A1 (HMGA1) gene is widely overexpressed in diverse cancers and portends a poor prognosis in some tumors, the molecular…”
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HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche by Xian, Lingling, Georgess, Dan, Huso, Tait, Cope, Leslie, Belton, Amy, Chang, Yu-Ting, Kuang, Wenyong, Gu, Qihua, Zhang, Xiaoyan, Senger, Stefania, Fasano, Alessio, Huso, David L., Ewald, Andrew J., Resar, Linda M. S.

“…High-mobility group A1 (Hmga1) chromatin remodelling proteins are enriched in intestinal stem cells (ISCs), although their function in this setting was…”
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Use of pegylated interferon in young patients with polycythemia vera and essential thrombocythemia by Kucine, Nicole, Bergmann, Shayla, Krichevsky, Spencer, Jones, Devin, Rytting, Michael, Jain, Juhi, Bennett, Carolyn M., Resar, Linda M.S., Mascarenhas, John, Verstovsek, Srdan, Hoffman, Ronald

“…Myeloproliferative neoplasms (MPN) are rare disorders in young patients, and because of this, standardized treatment recommendations are not available…”
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High mobility group A1 (HMGA1) protein and gene expression correlate with ER-negativity and poor outcomes in breast cancer by Gorbounov, Mikhail, Carleton, Neil M., Asch-Kendrick, Rebecca J., Xian, Lingling, Rooper, Lisa, Chia, Lionel, Cimino-Mathews, Ashley, Cope, Leslie, Meeker, Alan, Stearns, Vered, Veltri, Robert W., Bae, Young Kyung, Resar, Linda M. S.

“…Purpose The high mobility group A1 (HMGA1) chromatin remodeling protein is required for metastatic progression and cancer stem cell properties in preclinical…”
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HMGA1 chromatin regulators induce transcriptional networks involved in GATA2 and proliferation during MPN progression by Li, Liping, Kim, Jung-Hyun, Lu, Wenyan, Williams, Donna M., Kim, Joseph, Cope, Leslie, Rampal, Raajit K., Koche, Richard P., Xian, Lingling, Luo, Li Z., Vasiljevic, Marija, Matson, Daniel R., Zhao, Zhizhuang Joe, Rogers, Ophelia, Stubbs, Matthew C., Reddy, Karen, Romero, Antonio-Rodriguez, Psaila, Bethan, Spivak, Jerry L., Moliterno, Alison R., Resar, Linda M.S.

“…Myeloproliferative neoplasms (MPNs) transform to myelofibrosis (MF) and highly lethal acute myeloid leukemia (AML), although the actionable mechanisms driving…”
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A Propensity-Matched Cohort Study of Intravenous Iron versus Red Cell Transfusions for Preoperative Iron-Deficiency Anemia by Choi, Una E, Nicholson, Ryan C, Thomas, Ananda J, Crowe, Elizabeth P, Ulatowski, John A, Resar, Linda M S, Hensley, Nadia B, Frank, Steven M

“…While preoperative anemia is associated with adverse perioperative outcomes, the benefits of treatment with iron replacement versus red blood cell (RBC)…”
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Greater Than Sevenfold Return on Investment for a Comprehensive Patient Blood Management Program With Equivalent or Improved Outcomes by Frank, Steven M, Hensley, Nadia B, Thomas, Ananda J, Dawson, Clarita G, Resar, Linda M S, Ulatowski, John A, Crowe, Elizabeth P

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