Search Results - "Requena, Jesús R."

Full atomistic model of prion structure and conversion by Spagnolli, Giovanni, Rigoli, Marta, Orioli, Simone, Sevillano, Alejandro M, Faccioli, Pietro, Wille, Holger, Biasini, Emiliano, Requena, Jesús R

“…Prions are unusual protein assemblies that propagate their conformationally-encoded information in absence of nucleic acids. The first prion identified, the…”
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Unlatching a window into the molecular landscape of prion toxicity by Requena, Jesús R.

“…A study published in Nature Structural & Molecular Biology now unveils, at the atomic level, the initial mechanisms of prion toxicity, providing insights into…”
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The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy by Vázquez-Fernández, Ester, Vos, Matthijn R, Afanasyev, Pavel, Cebey, Lino, Sevillano, Alejandro M, Vidal, Enric, Rosa, Isaac, Renault, Ludovic, Ramos, Adriana, Peters, Peter J, Fernández, José Jesús, van Heel, Marin, Young, Howard S, Requena, Jesús R, Wille, Holger

“…The structure of the infectious prion protein (PrPSc), which is responsible for Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy, has…”
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The protean prion protein by Requena, Jesús R

“…The prion protein, PrP, can adopt at least 2 conformations, the overwhelmingly prevalent cellular conformation (PrP.sup.C) and the scrapie conformation…”
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The Structure of PrPSc Prions by Wille, Holger, Requena, Jesús

“…PrPSc (scrapie isoform of the prion protein) prions are the infectious agent behind diseases such as Creutzfeldt–Jakob disease in humans, bovine spongiform…”
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Time of Detection of Prions in the Brain by Nanoscale Liquid Chromatography Coupled to Tandem Mass Spectrometry Is Comparable to Animal Bioassay by Silva, Christopher J, Onisko, Bruce C, Dynin, Irina C, Erickson-Beltran, Melissa, Requena, Jesús R

“…Prions cause transmissible and inevitably fatal neurological diseases in agriculturally important animals, including bovine spongiform encephalopathy in…”
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Elucidating the structure of an infectious protein by Zweckstetter, Markus, Requena, Jesús R, Wille, Holger

“…About the Authors: Markus Zweckstetter Affiliations Deutsches Zentrum für Neurodegenerative Erkrankungen, Göttingen, Germany, Max Planck Institute for…”
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All-atom simulation of the HET-s prion replication by Terruzzi, Luca, Spagnolli, Giovanni, Boldrini, Alberto, Requena, Jesús R, Biasini, Emiliano, Faccioli, Pietro, Ben-Tal, Nir, Shakhnovich, Eugene I

“…Prions are self-replicative protein particles lacking nucleic acids. Originally discovered for causing infectious neurodegenerative disorders, they have also…”
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Human VGF-Derived Antidepressant Neuropeptide TLQP62 Promotes SH-SY5Y Neurite Outgrowth by Moutinho, Daniela, Veiga, Sónia, Requena, Jesús R.

“…TLQP62 is a neuropeptide derived from the neurotrophin-inducible VGF (non-acronymic) protein with antidepressant-like properties capable of inducing increased…”
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Proteinase K and the structure of PrPSc: The good, the bad and the ugly by Silva, Christopher J., Vázquez-Fernández, Ester, Onisko, Bruce, Requena, Jesús R.

“…Infectious proteins (prions) are, ironically, defined by their resistance to proteolytic digestion. A defining characteristic of the transmissible isoform of…”
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The Structure of the Infectious Prion Protein and Its Propagation by Requena, Jesús R, Wille, Holger

“…The prion diseases, which include Creutzfeldt-Jakob disease in humans, chronic wasting disease in cervids (i.e., deer, elk, moose, and reindeer), bovine…”
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The structure of the infectious prion protein: Experimental data and molecular models by Requena, Jesús R, Wille, Holger

“…The structures of the infectious prion protein, PrP Sc , and that of its proteolytically truncated variant, PrP 27-30, have evaded experimental determination…”
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Ok Google, how could I design therapeutics against prion diseases? by Rigoli, Marta, Spagnolli, Giovanni, Faccioli, Pietro, Requena, Jesús R, Biasini, Emiliano

“…A number of previous successful attempts in the search for therapeutics for a variety of human pathologies highlight the importance of computational…”
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The human VGF-derived bioactive peptide TLQP-21 binds heat shock 71 kDa protein 8 (HSPA8)on the surface of SH-SY5Y cells by Akhter, Shamim, Chakraborty, Sandipan, Moutinho, Daniela, Álvarez-Coiradas, Elia, Rosa, Isaac, Viñuela, Juan, Domínguez, Eduardo, García, Angel, Requena, Jesús R

“…VGF (non-acronymic)is a secreted chromogranin/secretogranin that gives rise to a number of bioactive peptides by a complex proteolysis mechanism. VGF-derived…”
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Prion-like diseases: Looking for their niche in the realm of infectious diseases by Castilla, Joaquín, Requena, Jesús R.

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A new seipin-associated neurodegenerative syndrome by Guillén-Navarro, Encarna, Sánchez-Iglesias, Sofía, Domingo-Jiménez, Rosario, Victoria, Berta, Ruiz-Riquelme, Alejandro, Rábano, Alberto, Loidi, Lourdes, Beiras, Andrés, González-Méndez, Blanca, Ramos, Adriana, López-González, Vanesa, Ballesta-Martínez, María Juliana, Garrido-Pumar, Miguel, Aguiar, Pablo, Ruibal, Alvaro, Requena, Jesús R, Araújo-Vilar, David

“…Seipin/BSCL2 mutations can cause type 2 congenital generalised lipodystrophy (BSCL) or dominant motor neurone diseases. Type 2 BSCL is frequently associated…”
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Insolubility of Disrupted-in-Schizophrenia 1 Disrupts Oligomer-Dependent Interactions with Nuclear Distribution Element 1 and Is Associated with Sporadic Mental Disease by Leliveld, S. Rutger, Bader, Verian, Hendriks, Philipp, Prikulis, Ingrid, Sajnani, Gustavo, Requena, Jesus R, Korth, Carsten

“…Disrupted-in-schizophrenia 1 (DISC1) and other genes have been identified recently as potential molecular players in chronic psychiatric diseases such as…”
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Recombinant PrPSc shares structural features with brain-derived PrPSc: Insights from limited proteolysis by Sevillano, Alejandro M, Fernández-Borges, Natalia, Younas, Neelam, Wang, Fei, R Elezgarai, Saioa, Bravo, Susana, Vázquez-Fernández, Ester, Rosa, Isaac, Eraña, Hasier, Gil, David, Veiga, Sonia, Vidal, Enric, Erickson-Beltran, Melissa L, Guitián, Esteban, Silva, Christopher J, Nonno, Romolo, Ma, Jiyan, Castilla, Joaquín, R Requena, Jesús

“…Very solid evidence suggests that the core of full length PrPSc is a 4-rung β-solenoid, and that individual PrPSc subunits stack to form amyloid fibers. We…”
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Structural organization of mammalian prions as probed by limited proteolysis by Vázquez-Fernández, Ester, Alonso, Jana, Pastrana, Miguel A, Ramos, Adriana, Stitz, Lothar, Vidal, Enric, Dynin, Irina, Petsch, Benjamin, Silva, Christopher J, Requena, Jesús R

“…Elucidation of the structure of PrP(Sc) continues to be one major challenge in prion research. The mechanism of propagation of these infectious agents will not…”
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Determining the Relative Susceptibility of Four Prion Protein Genotypes to Atypical Scrapie by Silva, Christopher J, Erickson-Beltran, Melissa L, Martín-Burriel, Inmaculada, Badiola, Juan José, Requena, Jesús R, Bolea, Rosa

“…Atypical scrapie is a sheep prion (PrPSc) disease whose epidemiology is consistent with a sporadic origin and is associated with specific polymorphisms of the…”
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