Search Results - "Repke, David B"

Highly potent, non-basic 5-HT6 ligands. Site mutagenesis evidence for a second binding mode at 5-HT6 for antagonism by Harris, Ralph N., Stabler, Russel S., Repke, David B., Kress, James M., Walker, Keith A., Martin, Renee S., Brothers, Julie M., Ilnicka, Mariola, Lee, Simon W., Mirzadegan, Tara

“…A series of 5-HT6 ligands derived from (R)-1-(amino)methyl-6-(phenyl)sulfonyltetralin was prepared that yielded several neutral, non-basic analogs having…”
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Structure-affinity relationships of 12-sulfonyl derivatives of 5,8,8a,9,10,11,12,12a,13,13a-decahydro-6H-isoquino[2,1-g][1,6]naphthyridines at .alpha.-adrenoceptors by Clark, Robin D, Repke, David B, Berger, Jacob, Nelson, Janis T, Kilpatrick, Andrew T, Brown, Christine M, MacKinnon, Alison C, Clague, Ruth U, Spedding, Michael

“…Analogues of the potent alpha 2-adrenoceptor antagonist (8aR,12aS,13aS)-5,8,8a,9,10,11,12,12a,13,13a- decahydro-3-methoxy-12-(methylsulfonyl)-…”
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Synthesis and antihypertensive activity of 4'-substituted spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-ones by Clark, Robin D, Caroon, Joan M, Kluge, Arthur F, Repke, David B, Roszkowski, Adolph P, Strosberg, Arthur M, Baker, Stephen, Bitter, Susan M, Okada, Marlys D

“…A series of 4'-substituted spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-ones was prepared and evaluated for antihypertensive activity in the spontaneously…”
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2-(Quinuclidin-3-yl)pyrido[4,3-b]indol-1-ones and isoquinolin-1-ones. Potent conformationally restricted 5-HT3 receptor antagonists by Clark, Robin D, Miller, Aaron B, Berger, Jacob, Repke, David B, Weinhardt, Klaus K, Kowalczyk, Bruce A, Eglen, Richard M, Bonhaus, Douglas W, Lee, Chi Ho

“…Several series of N-(quinuclidin-3-yl)aryl and heteroaryl-fused pyridones were synthesized and evaluated for 5-HT3 receptor affinity. In the heteroaryl series,…”
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N-Arylpiperazinyl-N‘-propylamino Derivatives of Heteroaryl Amides as Functional Uroselective α1-Adrenoceptor Antagonists by Elworthy, Todd R, Ford, Anthony P. D. W, Bantle, Gary W, Morgans, David J, Ozer, Rachel S, Palmer, Wylie S, Repke, David B, Romero, Magarita, Sandoval, Leticia, Sjogren, Eric B, Talamás, Francisco X, Vazquez, Alfredo, Wu, Helen, Arredondo, Nicolas F, Blue, David R, DeSousa, Andrea, Gross, Lisa M, Kava, M. Shannon, Lesnick, John D, Vimont, Rachel L, Williams, Timothy J, Zhu, Quan-Ming, Pfister, Jürg R, Clarke, David E

“…Novel arylpiperazines were identified as α1-adrenoceptor (AR) subtype-selective antagonists by functional in vitro screening. 3-[4-(ortho-Substituted…”
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Abbreviated Ibogaine Congeners. Synthesis and Reactions of Tropan-3-yl-2- and -3-indoles. Investigation of an Unusual Isomerization of 2-Substituted Indoles Using Computational and Spectroscopic Techniques by Repke, David B, Artis, Dean R, Nelson, Janis T, Wong, Erik H. F

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Snuff Powders from Pre-Hispanic San Pedro de Atacama: Chemical and Contextual Analysis by Torres, Constantino Manuel, Repke, David B., Chan, Kelvin, McKenna, Dennis, Llagostera, Agustin, Schultes, Richard Evans

“…The use of hallucinogenic plants in pre-Hispanic South America is discussed, and the results of the first analysis identifying psychoactive components in snuff…”
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(8a.alpha.,12a.alpha.,13a.alpha.)-5,8,8a,9,10,11,12,12a,13,13a,-Decahydro-3-methoxy-12-(methylsulfonyl)-6H-isoquino[2,1-g][1,6]naphthyridine, a potent and highly selective .alpha.2-adrenoceptor antagonist by Clark, Robin D, Repke, David B, Kilpatrick, Andrew T, Brown, Christine M, MacKinnon, Alison C, Clague, Ruth U, Spedding, Michael

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C-Glycosyl nucleosides. II. Facile synthesis of derivatives of 2,5-anhydro-D-allose by Albrecht, Hans O, Repke, David B, Moffatt, John G

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C-Glycosyl nucleosides. IV. Synthesis of several 4-(.beta.-D-ribofuranosyl)pyrazoles by Albrecht, Hans P, Repke, David B, Moffatt, John G

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C-Glycosyl nucleosides. VI. Synthesis of several 3- and 5-(.beta.-D-ribofuranosyl)isoxazoles by Albrecht, Hans P, Repke, David B, Moffatt, John G

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C-Glycosyl nucleosides. VIII. Synthesis of 3-methylshowdomycin by Trummlitz, Gunter, Repke, David B, Moffatt, John G

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Highly potent, non-basic 5-HT sub(6) ligands. Site mutagenesis evidence for a second binding mode at 5-HT sub(6) for antagonism by Harris, Ralph N, Stabler, Russel S, Repke, David B, Kress, James M, Walker, Keith A, Martin, Renee S, Brothers, Julie M, Ilnicka, Mariola, Lee, Simon W, Mirzadegan, Tara

“…A series of 5-HT sub(6) ligands derived from (R)-1-(amino)methyl-6-(phenyl)sulfonyltetralin was prepared that yielded several non-basic analogs having…”
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Psychotomimetic N-methyl-N-isopropyltryptamines. Effects of variation of aromatic oxygen substituents by Repke, David B, Grotjahn, Douglas B, Shulgin, Alexander T

“…Eight N-methyl-N-isopropyltryptamines (MIPTs) possessing various aromatic oxygen substituents were prepared, characterized, and evaluated for hallucinogenic…”
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Synthetic studies on naulafine by REPKE, D. B, JAHANGIR, CLARK, R. D, NELSON, J. T

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Psilocin analogs II. Synthesis of 3-[2-(dialkylamino)ethyl]-, 3-[2-(N-methyl-N-alkylamino)ethyl]-, and 3-[2-(cycloalkylamino)ethyl]indol-4-ols by Repke, David B., Ferguson, Wilfred J., Bates, Dallas K.

“…Structural alteration of the Nb‐substituents of psilocin (3‐[2‐dimethylamino)ethyl]indol‐4‐ol) (12a) has led to a number of compounds containing known…”
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C-Glycosyl nucleosides. VII. Synthesis of some 3-.beta.-D-ribofuranosyl-1,2,4-oxadiazoles and 3-.beta.-D-ribofuranosylpyrazoles by Repke, David B, Albrecht, Hans P, Moffatt, John G

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Psilocin analogs. 1. Synthesis of 3-[2-(dialkylamino)ethyl] -and 3-[2-(cycloalkylamino)ethyl] indol-4-ols by Repke, David B., Ferguson, Wilfred J., Bates, Dallas K.

“…The synthesis of four dialkyl and three eyeloalkyl analogs of psilocin (4, R ‐ CH3), a hallucinogenic principle found in certain fungi, is described. The…”
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Antihypertensive 9-substituted 1-0xa-4,9-diazaspiro[5.5]undecan-3-ones by Clark, Robin D, Caroon, Joan M, Repke, David B, Strosberg, Arthur M, Bitter, Susan M, Okada, Marlys D, Michel, Anton D, Whiting, Roger L

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Synthesis of dextroamphetamine sulfate and methamphetamine hydrochloride from D-phenylalanine by Repke, D B, Bates, D K, Ferguson, W J

“…Starting from D-phenylalanine, dextroamphetamine sulfate and methamphetamine hydrochloride were synthesized. The reaction sequence proceeds through three…”
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