Search Results - "Repasky, EA"

Next Directions in the Neuroscience of Cancers Arising outside the CNS by Amit, Moran, Anastasaki, Corina, Dantzer, Robert, Demir, Ihsan Ekin, Deneen, Benjamin, Dixon, Karen O, Egeblad, Mikala, Gibson, Erin M, Hervey-Jumper, Shawn L, Hondermarck, Hubert, Magnon, Claire, Monje, Michelle, Na'ara, Shorook, Pan, Yuan, Repasky, Elizabeth A, Scheff, Nicole N, Sloan, Erica K, Talbot, Sebastien, Tracey, Kevin J, Trotman, Lloyd C, Valiente, Manuel, Van Aelst, Linda, Venkataramani, Varun, Venkatesh, Humsa S, Vermeer, Paola D, Winkler, Frank, Wong, Richard J, Gutmann, David H, Borniger, Jeremy C

“…The field of cancer neuroscience has begun to define the contributions of nerves to cancer initiation and progression; here, we highlight the future directions…”
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Promoter Hypermethylation and BRCA1 Inactivation in Sporadic Breast and Ovarian Tumors by Esteller, Manel, Silva, Jose Maria, Dominguez, Gemma, Bonilla, Felix, Matias-Guiu, Xavier, Lerma, Enrique, Bussaglia, Elena, Prat, Jaime, Harkes, I. Clara, Repasky, Elizabeth A., Gabrielson, Edward, Schutte, Mieke, Baylin, Stephen B., Herman, James G.

“…Background: Inherited mutations in the BRCA1 gene may be responsible for almost half of inherited breast carcinomas. However, somatic (acquired) mutations in…”
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Emerging evidence indicates that physiologically relevant thermal stress regulates dendritic cell function by Ostberg, Julie R, Repasky, Elizabeth A

“…Elevations in temperature that are associated with inflammation or fever have been linked to improved survival from infections, enhanced immunological…”
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Effects of tumor necrosis factor-related apoptosis-inducing ligand alone and in combination with chemotherapeutic agents on patients' colon tumors grown in SCID mice by NAKA, Takuji, SUGAMURA, Kenji, HYLANDER, Bonnie L, WIDMER, Michael B, RUSTUM, Youcef M, REPASKY, Elizabeth A

“…Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been reported to induce apoptosis in a variety of malignant cell lines, but it shows little…”
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Influence of the implantation site on the sensitivity of patient pancreatic tumor xenografts to Apo2L/TRAIL therapy by Sharma, Rohit, Buitrago, Sandra, Pitoniak, Rose, Gibbs, John F, Curtin, Leslie, Seshadri, Mukund, Repasky, Elizabeth A, Hylander, Bonnie L

“…We have previously demonstrated activity of Apo2L/TRAIL against patient pancreatic tumor xenografts. Here, we have examined the influence of the tumor…”
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HSP110-HER2/neu Chaperone Complex Vaccine Induces Protective Immunity Against Spontaneous Mammary Tumors in HER-2/neu Transgenic Mice by Manjili, Masoud H, Wang, Xiang-Yang, Chen, Xing, Martin, Thomas, Repasky, Elizabeth A, Henderson, Robert, Subjeck, John R

“…Heat shock proteins (HSPs) are shown to be strong immunoadjuvants, eliciting both innate and adaptive immune responses against cancers. HSP110 is related in…”
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Characterization of Heat Shock Protein 110 and Glucose-Regulated Protein 170 as Cancer Vaccines and the Effect of Fever-Range Hyperthermia on Vaccine Activity by Wang, Xiang-Yang, Kazim, Latif, Repasky, Elizabeth A, Subjeck, John R

“…Several studies have confirmed that certain stress proteins can function as potent vaccines against a specific cancer when purified from the same tumor. Recent…”
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Chaperoning function of stress protein grp170, a member of the hsp70 superfamily, is responsible for its immunoadjuvant activity by PARK, Jun-Eui, FACCIPONTE, John, XING CHEN, MACDONALD, Ian, REPASKY, Elizabeth A, MANJILI, Masoud H, WANG, Xiang-Yang, SUBJECK, John R

“…When used as vaccines, tumor-derived stress proteins can elicit antitumor immune responses. For members of the hsp70 superfamily, like grp170, this seems to be…”
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The anti-tumor effect of Apo2L/TRAIL on patient pancreatic adenocarcinomas grown as xenografts in SCID mice by Hylander, Bonnie L, Pitoniak, Rose, Penetrante, Remedios B, Gibbs, John F, Oktay, Dilek, Cheng, Jinrong, Repasky, Elizabeth A

“…BACKGROUND: Apo2L/TRAIL has considerable promise for cancer therapy based on the fact that this member of the tumor necrosis factor family induces apoptosis in…”
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Immunization with tumor‐derived ER chaperone grp170 elicits tumor‐specific CD8+ T‐cell responses and reduces pulmonary metastatic disease by Wang, Xiang‐Yang, Kazim, Latif, Repasky, Elizabeth A., Subjeck, John R.

“…Glucose‐regulated protein (grp) 170 is a molecular chaperone localized in endoplasmic reticulum (ER), which has been demonstrated to interact with the peptides…”
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Recombinant CD40 ligand therapy has significant antitumor effects on CD40-positive ovarian tumor xenografts grown in SCID mice and demonstrates an augmented effect with cisplatin by GHAMANDE, Sharad, HYLANDER, Bonnie L, OFLAZOGLU, Ezogelin, LELE, Shashikant, FANSLOW, William, REPASKY, Elizabeth A

“…CD40 is a member of the tumor necrosis factor receptor family and was first identified with a monoclonal antibody raised against bladder carcinoma. Recombinant…”
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Fever-range hyperthermia dynamically regulates lymphocyte delivery to high endothelial venules by Evans, Sharon S., Wang, Wan-Chao, Bain, Mark D., Burd, Randy, Ostberg, Julie R., Repasky, Elizabeth A.

“…Fever is associated with increased survival during acute infection, although its mechanism of action is largely unknown. This study found evidence of an…”
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Prostein expression is highly restricted to normal and malignant prostate tissues by Kalos, Michael, Askaa, Jon, Hylander, Bonnie L., Repasky, Elisabeth A., Cai, Feng, Vedvick, Thomas, Reed, Steven G., Wright Jr, George L., Fanger, Gary R.

“…BACKGROUND Prostein is a recently described molecule expressed at the mRNA level in a prostate‐specific manner. A murine monoclonal antibody was developed,…”
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Regulatory effects of fever-range whole-body hyperthermia on the LPS-induced acute inflammatory response by Ostberg, Julie R., Taylor, Shannon L., Baumann, Heinz, Repasky, Elizabeth A.

“…The thermal component of fever is one of the most poorly understood aspects of inflammation. To evaluate the role of fever‐range hyperthermia on acute…”
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Tumor cell apoptosis, lymphocyte recruitment and tumor vascular changes are induced by low temperature, long duration (fever-like) whole body hyperthermia by Burd, Randy, Dziedzic, Thomas S., Xu, Yan, Caligiuri, Michael A., Subjeck, John R., Repasky, Elizabeth A.

“…A single treatment of low‐temperature, long‐duration, whole‐body hyperthermia of either severe combined immunodeficient (SCID) mice bearing human breast tumor…”
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Regulatory Potential of Fever-Range Whole Body Hyperthermia on Langerhans Cells and Lymphocytes in an Antigen-Dependent Cellular Immune Response by Ostberg, Julie R, Gellin, Caren, Patel, Rahul, Repasky, Elizabeth A

“…The febrile response is one of the most common features of infection and inflammation. However, temperature is rarely a variable in experimental immunological…”
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Concurrent administration of granulocyte colony-stimulating factor or granulocyte-monocyte colony-stimulating factor enhances the biological activity of rituximab in a severe combined immunodeficiency mouse lymphoma model by Hernandez-Ilizaliturri, Francisco J, Jupudy, Venkata, Reising, Scott, Repasky, Elizabeth A, Czuczman, Myron S

“…A predominant percentage of the in vivo antitumor activity of rituximab occurs through antibody-dependent cellular cytotoxicity (ADCC) via FcgammaRIII…”
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Thermal regulation of dendritic cell activation and migration from skin explants by Ostberg, J R, Kabingu, E, Repasky, E A

“…Dendritic cells (DCs) in the skin rapidly take up antigen and migrate out of the skin to draining lymph nodes for antigen presentation. As a result, these…”
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Discovery of differentially expressed genes in human breast cancer using subtracted cDNA libraries and cDNA microarrays by YUQIU JIANG, HARLOCKER, Susan L, MOLESH, David A, DILLON, David C, STOLK, John A, HOUGHTON, Raymond L, REPASKY, Elizabeth A, BADARO, Roberto, REED, Steven G, JIANGCHUN XU

“…Identifying novel and known genes that are differentially expressed in breast cancer has important implications in understanding the biology of breast…”
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Nitric oxide production is regulated by fever-range thermal stimulation of murine macrophages by Pritchard, Michele T., Li, Zihai, Repasky, Elizabeth A.

“…As macrophages are often called to function at times of elevated ambient temperature (e.g., during local inflammation or systemic fever), it is possible that…”
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