Search Results - "Rep, M H"

Treatment with depleting CD4 monoclonal antibody results in a preferential loss of circulating naive T cells but does not affect IFN-gamma secreting TH1 cells in humans by Rep, M H, van Oosten, B W, Roos, M T, Adèr, H J, Polman, C H, van Lier, R A

“…CD4(pos) TH1 T cells are considered to play a central role in a number of human autoimmune diseases such as rheumatoid arthritis (RA) and multiple sclerosis…”
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Seasonal variation in immune measurements and MRI markers of disease activity in MS by KILLESTEIN, J, REP, M. H. G, MEILOF, J. F, ADER, H. J, UITDEHAAG, B. M. J, BARKHOF, F, VAN LIER, R. A. W, POLMAN, C. H

“…The exact mechanisms by which T cells contribute to MS progression are not known. Recently, the results of cross-sectional studies suggested seasonal variation…”
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Phenotypic and functional separation of memory and effector human CD8+ T cells by Hamann, D, Baars, P A, Rep, M H, Hooibrink, B, Kerkhof-Garde, S R, Klein, M R, van Lier, R A

“…Human CD8+ memory- and effector-type T cells are poorly defined. We show here that, next to a naive compartment, two discrete primed subpopulations can be…”
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Functional defects in peripheral blood T cells of multiple sclerosis patients. Diminished in vitro responsiveness in accessory cell dependent activation systems by Rep, M H, Hintzen, R Q, Polman, C H, van Lier, R A

“…Function and phenotype of peripheral blood (PB) T cells in multiple sclerosis (MS) patients were analyzed. In whole blood cultures, T cell proliferation of…”
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Interferon (IFN)-β treatment enhances CD95 and interleukin 10 expression but reduces interferon-γ producing T cells in MS patients by Rep, Martin H.G, Schrijver, Hans M, van Lopik, Thea, Hintzen, Rogier Q, Roos, Marijke T.L, Adèr, Herman J, Polman, Chris H, van Lier, René A.W

“…Interferon (IFN)-β has been shown to favorably alter the disease course of relapsing-remitting multiple sclerosis (RRMS) patients. Although its mode of action…”
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Recombinant Interferon-β blocks proliferation but enhances interleukin-10 secretion by activated human T-cells by Rep, Martin H.G., Hintzen, Rogier Q., Polman, Chris H., van Lier, RenéA.W.

“…Results from recent clinical trials have indicated that recombinant interferon-β (rIFN-β) is a promising drug for the treatment of Multiple Sclerosis (MS), a…”
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Active MRI lesion appearance in MS patients is preceded by fluctuations in circulating T-helper 1 and 2 cells by Killestein, Joep, Rep, Martin H.G, Barkhof, Frederik, Roos, Marijke T.L, Adèr, Herman J, van Lier, René A.W, Polman, Chris H

“…Background: The role of T cell subpopulations and their ability to produce immunoregulatory cytokines has been extensively studied in multiple sclerosis (MS)…”
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A pilot study investigating the effects of orally administered pentoxifylline on selected immune variables in patients with multiple sclerosis by Van Oosten, B.W., Rep, M.H.G., Van Lier, R.A.W., Scholten, P.E.T., Von Blomberg, B.M.E., Pflughaupt, K.W., Hartung, H.P., Adér, H.J., Polman, C.H.

“…Multiple sclerosis is probably mainly mediated by T-helper 1 (T H1)-lymphocytes. T H1-function can be down-regulated in vitro and in animal experiments by…”
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