Search Results - "Renzo, Maria Flavia Di"

ERα as ligand-independent activator of CDH-1 regulates determination and maintenance of epithelial morphology in breast cancer cells by Cardamone, Maria Dafne, Bardella, Chiara, Gutierrez, Arantxa, Di Croce, Luciano, Rosenfeld, Michael G, Di Renzo, Maria Flavia, De Bortoli, Michele

“…Estrogen receptor α (ERα) and E-cadherin are primary markers of luminal epithelial breast cancer cells with E-cadherin being a main caretaker of the epithelial…”
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Sparsely-connected autoencoder (SCA) for single cell RNAseq data mining by Alessandri, Luca, Cordero, Francesca, Beccuti, Marco, Licheri, Nicola, Arigoni, Maddalena, Olivero, Martina, Di Renzo, Maria Flavia, Sapino, Anna, Calogero, Raffaele

“…Single-cell RNA sequencing (scRNAseq) is an essential tool to investigate cellular heterogeneity. Thus, it would be of great interest being able to disclose…”
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Expression Profiling in Progressive Stages of Fumarate-Hydratase Deficiency: The Contribution of Metabolic Changes to Tumorigenesis by ASHRAFIAN, Houman, O'FLAHERTY, Linda, MIRANDA, Melroy, HOWARTH, Kimberley, SHUKLA, Deepa, TROY, Helen, GRIFFITHS, John, SPENCER-DENE, Bradley, YUSUF, Mohammed, VOLPI, Emanuela, MAXWELL, Patrick H, STAMP, Gordon, ADAM, Julie, POULSOM, Richard, PUGH, Christopher W, COSTA, Barbara, BARDELLA, Chiara, FLAVIA DI RENZO, Maria, KOTLIKOFF, Michael I, LAUNONEN, Virpi, AALTONEN, Lauri, EL-BAHRAWY, Mona, TOMLINSON, Ian, STEEPLES, Violetta, POLLARD, Patrick J, CHUNG, Yuen-Li, EAST, Phil, VANHARANTA, Sakari, LEHTONEN, Heli, NYE, Emma, HATIPOGLU, Emine

“…Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is caused by mutations in the Krebs cycle enzyme fumarate hydratase (FH). It has been proposed that…”
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Overexpression of the RON gene in human breast carcinoma by MAGGIORA, P, MARCHIO', S, STELLA, M. C, GIAI, M, BELFIORE, A, DE BORTOLI, M, DI RENZO, M. F, COSTANTINO, A, SISMONDI, P, COMOGLIO, P. M

“…Constitutive activation of the RON gene, known to code for the tyrosine-kinase receptor for Macrophage Stimulating Protein (also known as Scatter Factor 2),…”
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The integrin-linked kinase-associated phosphatase (ILKAP) is a regulatory hub of ovarian cancer cell susceptibility to platinum drugs by Lorenzato, Annalisa, Torchiaro, Erica, Olivero, Martina, Di Renzo, Maria Flavia

“…Abstract Background Platinum drugs are the most powerful chemotherapeutic agents in the treatment of ovarian cancer. We demonstrated previously that…”
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Cancer Cells Haploinsufficient for ATM Are Sensitized to PARP Inhibitors by MET Inhibition by D'Ambrosio, Concetta, Erriquez, Jessica, Capellero, Sonia, Cignetto, Simona, Alvaro, Maria, Ciamporcero, Eric, Di Renzo, Maria Flavia, Perera, Timothy, Valabrega, Giorgio, Olivero, Martina

“…The oncogene encodes a tyrosine kinase (TK) receptor. Its activation protects cells from death but also stimulates DNA damage response by triggering excess…”
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HSP27 is required for invasion and metastasis triggered by hepatocyte growth factor by Pavan, Simona, Musiani, Daniele, Torchiaro, Erica, Migliardi, Giorgia, Gai, Marta, Cunto, Ferdinando, Erriquez, Jessica, Olivero, Martina, Renzo, Maria Flavia

“…The hepatocyte growth factor (HGF) also known as scatter factor activates cancer cell invasion and metastasis. We show that in ovarian cancer cells HGF induced…”
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Genetic and Expression Analysis of MET, MACC1, and HGF in Metastatic Colorectal Cancer: Response to Met Inhibition in Patient Xenografts and Pathologic Correlations by GALIMI, Francesco, TORTI, Davide, PARALUPPI, Gianluca, GONELLA, Federica, MAIONE, Francesca, PISACANE, Alberto, DAVID, Ezio, TORCHIO, Bruno, RISIO, Mauro, SALIZZONI, Mauro, CAPUSSOTTI, Lorenzo, PERERA, Timothy, SASSI, Francesco, MEDICO, Enzo, DI RENZO, Maria Flavia, COMOGLIO, Paolo M, TRUSOLINO, Livio, BERTOTTI, Andrea, ISELLA, Claudio, CORA, Davide, GASTALDI, Stefania, RIBERO, Dario, MURATORE, Andrea, MASSUCCO, Paolo, SIATIS, Dimitrios

“…We determined the gene copy numbers for MET, for its transcriptional activator MACC1 and for its ligand hepatocyte growth factor (HGF) in liver metastases from…”
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CD99 Drives Terminal Differentiation of Osteosarcoma Cells by Acting as a Spatial Regulator of ERK 1/2 by Sciandra, Marika, Marino, Maria Teresa, Manara, Maria Cristina, Guerzoni, Clara, Grano, Maria, Oranger, Angela, Lucarelli, Enrico, Lollini, Pier‐Luigi, Dozza, Barbara, Pratelli, Loredana, Di Renzo, Maria Flavia, Colombo, Mario Paolo, Picci, Piero, Scotlandi, Katia

“…ABSTRACT Differentiation therapy is an attractive treatment for osteosarcoma (OS). CD99 is a cell surface molecule expressed in mesenchymal stem cells and…”
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TOP2A as marker of response to pegylated lyposomal doxorubicin (PLD) in epithelial ovarian cancers by Ghisoni, Eleonora, Maggiorotto, Furio, Borella, Fulvio, Mittica, Gloria, Genta, Sofia, Giannone, Gaia, Katsaros, Dionyssios, Sciarrillo, Alberto, Ferrero, Annamaria, Sarotto, Ivana, Erriquez, Jessica, Di Renzo, Maria Flavia, Aglietta, Massimo, Valabrega, Giorgio

“…Relapsed epithelial ovarian cancer (EOC) is frequently treated with pegylated liposomal doxorubicin (PLD). Unfortunately, most patients do not benefit from…”
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Cells Lacking the Fumarase Tumor Suppressor Are Protected from Apoptosis through a Hypoxia-Inducible Factor-Independent, AMPK-Dependent Mechanism by Bardella, Chiara, Olivero, Martina, Lorenzato, Annalisa, Geuna, Massimo, Adam, Julie, O'Flaherty, Linda, Rustin, Pierre, Tomlinson, Ian, Pollard, Patrick J., Di Renzo, Maria Flavia

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Caveolin-1 reduces osteosarcoma metastases by inhibiting c-src activity and met signaling by CANTIANI, Lara, MANARA, Maria Cristina, PICCI, Piero, SCOTLANDI, Katia, ZUCCHINI, Cinzia, DE SANCTIS, Paola, ZUNTINI, Monia, VALVASSORI, Luisa, SERRA, Massimo, OLIVERO, Martina, DI RENZO, Maria Flavia, COLOMBO, Mario Paolo

“…Caveolin-1 (Cav-1) is highly expressed in normal osteoblasts. This article reports that Cav-1 down-regulation is part of osteoblast transformation and…”
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Xenopatients show the need for precision medicine approach to chemotherapy in ovarian cancer by Erriquez, Jessica, Olivero, Martina, Mittica, Gloria, Scalzo, Maria Stella, Vaira, Marco, De Simone, Michele, Ponzone, Riccardo, Katsaros, Dionyssios, Aglietta, Massimo, Calogero, Raffaele, Di Renzo, Maria Flavia, Valabrega, Giorgio

“…Platinum-based chemotherapy is the recommended first-line treatment for high-grade serous (HGS) epithelial ovarian cancer (EOC). However, most patients relapse…”
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PIK3R1W624R Is an Actionable Mutation in High Grade Serous Ovarian Carcinoma by D’Ambrosio, Concetta, Erriquez, Jessica, Arigoni, Maddalena, Capellero, Sonia, Mittica, Gloria, Ghisoni, Eleonora, Borella, Fulvio, Katsaros, Dionyssios, Privitera, Silvana, Ribotta, Marisa, Maldi, Elena, Di Nardo, Giovanna, Berrino, Enrico, Venesio, Tiziana, Ponzone, Riccardo, Vaira, Marco, Hall, Douglas, Jimenez-Linan, Mercedes, Paterson, Anna L., Calogero, Raffaele A., Brenton, James D., Valabrega, Giorgio, Di Renzo, Maria Flavia, Olivero, Martina

“…Identifying cancer drivers and actionable mutations is critical for precision oncology. In epithelial ovarian cancer (EOC) the majority of mutations lack…”
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Spontaneous feline mammary carcinoma is a model of HER2 overexpressing poor prognosis human breast cancer by DE MARIA, Raffaella, OLIVERO, Martina, IUSSICH, Selina, NAKAICHI, Munekazu, MURATA, Tomoaki, BIOLATTI, Bartolomeo, DI RENZO, Maria Flavia

“…Companion animal spontaneous tumors are suitable models for human cancer, primarily because both animal population and the tumors are genetically…”
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A mouse model of pulmonary metastasis from spontaneous osteosarcoma monitored in vivo by Luciferase imaging by Miretti, Silvia, Roato, Ilaria, Taulli, Riccardo, Ponzetto, Carola, Cilli, Michele, Olivero, Martina, Di Renzo, Maria Flavia, Godio, Laura, Albini, Adriana, Buracco, Paolo, Ferracini, Riccardo

“…Osteosarcoma (OSA) is lethal when metastatic after chemotherapy and/or surgical treatment. Thus animal models are necessary to study the OSA metastatic spread…”
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The Therapeutic Potential of Hepatocyte Growth Factor to Sensitize Ovarian Cancer Cells to Cisplatin and Paclitaxel In vivo by BARDELLA, Chiara, DETTORI, Daniela, OLIVERO, Martina, COLTELLA, Nadia, MAZZONE, Massimiliano, DI RENZO, Maria Flavia

“…Purpose: Advanced ovarian cancers are initially responsive to combinatorial chemotherapy with platinum drugs and taxanes but, in most cases, develop drug…”
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The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness by Maggiora, Piera, Lorenzato, Annalisa, Fracchioli, Stefano, Costa, Barbara, Castagnaro, Massimo, Arisio, Riccardo, Katsaros, Dionyssios, Massobrio, Marco, Comoglio, Paolo M, Flavia Di Renzo, Maria

“…RON is a member of the receptor tyrosine kinase gene family that includes the MET oncogene, whose germline mutations have been causally related to human…”
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Truncated RON tyrosine kinase drives tumor cell progression and abrogates cell-cell adhesion through E-cadherin transcriptional repression by BARDELLA, Chiara, COSTA, Barbara, MAGGIORA, Piera, PATANE, Salvatore, OLIVERO, Martina, RANZANI, Guglielmina N, DE BORTOLI, Michele, COMOGLIO, Paolo M, DI RENZO, Maria Flavia

“…RON is a tyrosine kinase receptor that triggers scattering of normal cells and invasive growth of cancer cells on ligand binding. We identified a short RON…”
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A cancer‐predisposing “hot spot” mutation of the fumarase gene creates a dominant negative protein by Lorenzato, Annalisa, Olivero, Martina, Perro, Mario, Brière, Jean Jacques, Rustin, Pierre, Renzo, Maria Flavia Di

“…The Fumarase (Fumarate Hydratase, FH) is a tumor suppressor gene whose germline heterozygous mutations predispose to hereditary leiomyomatosis and renal cell…”
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