Search Results - "Rentia, Uzma"

Locus specific endogenous retroviral expression associated with Alzheimer's disease by Dawson, Tyson, Rentia, Uzma, Sanford, Jessie, Cruchaga, Carlos, Kauwe, John S K, Crandall, Keith A

“…Human endogenous retroviruses (HERVs) are transcriptionally-active remnants of ancient retroviral infections that may play a role in Alzheimer's disease. We…”
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Validation of Variant Assembly Using HAPHPIPE with Next-Generation Sequence Data from Viruses by Gibson, Keylie M, Steiner, Margaret C, Rentia, Uzma, Bendall, Matthew L, Pérez-Losada, Marcos, Crandall, Keith A

“…Next-generation sequencing (NGS) offers a powerful opportunity to identify low-abundance, intra-host viral sequence variants, yet the focus of many…”
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Inhibition of DNMTs and RNA editing increases immunogenic transposable element RNA to reduce tumor burden and prolong survival in a murine ovarian cancer model by Gomez, Stephanie, Cox, Olivia L, Rentia, Uzma, Balick, Veronica, Hadley, Melissa, Grundy, Erin E, Kanholm, Tomas, McDonald, James I, Kobyra, Julie, Palmer, Erica, Saunthararajah, Yogen, Chiappinelli, Katherine B

“…Abstract Novel therapies are urgently needed for ovarian cancer (OC), the fifth deadliest cancer in women. Preclinical data shows great promise for the…”
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Oncogenic Transformation Drives DNA Methylation Loss and Transcriptional Activation at Transposable Element Loci by Kanholm, Tomas, Rentia, Uzma, Hadley, Melissa, Karlow, Jennifer A, Cox, Olivia L, Diab, Noor, Bendall, Matthew L, Dawson, Tyson, McDonald, James I, Xie, Wenbing, Crandall, Keith A, Burns, Kathleen H, Baylin, Stephen B, Easwaran, Hari, Chiappinelli, Katherine B

“…Transposable elements (TE) are typically silenced by DNA methylation and repressive histone modifications in differentiated healthy human tissues. However, TE…”
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Loss of Adar1 increases T cell migration and prolongs survival in ovarian cancer by Gomez, Stephanie, Grundy, Erin E, Kanholm, Tomas, Hadley, Melissa, McDonald, James I, Rentia, Uzma, Kobyra, Julie, Palmer, Erica, Saunthararajah, Yogen, Chiappinelli, Katherine B

“…Abstract Novel therapies are urgently needed for ovarian cancer (OC), the fifth deadliest cancer in women. OC is generally characterized by an…”
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Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a TP53 -Dependent Manner by McDonald, James I, Diab, Noor, Arthofer, Elisa, Hadley, Melissa, Kanholm, Tomas, Rentia, Uzma, Gomez, Stephanie, Yu, Angela, Grundy, Erin E, Cox, Olivia, Topper, Michael J, Xing, Xiaoyun, Strissel, Pamela L, Strick, Reiner, Wang, Ting, Baylin, Stephen B, Chiappinelli, Katherine B

“…Epithelial ovarian carcinomas are particularly deadly due to intratumoral heterogeneity, resistance to standard-of-care therapies, and poor response to…”
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HAPHPIPE: Haplotype Reconstruction and Phylodynamics for Deep Sequencing of Intrahost Viral Populations by Bendall, Matthew L, Gibson, Keylie M, Steiner, Margaret C, Rentia, Uzma, Pérez-Losada, Marcos, Crandall, Keith A

“…Abstract Deep sequencing of viral populations using next-generation sequencing (NGS) offers opportunities to understand and investigate evolution, transmission…”
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Inhibiting DNA methylation and RNA editing upregulates immunogenic RNA to transform the tumor microenvironment and prolong survival in ovarian cancer by Gomez, Stephanie, Cox, Olivia L, Walker, 3rd, Reddick R, Rentia, Uzma, Hadley, Melissa, Arthofer, Elisa, Diab, Noor, Grundy, Erin E, Kanholm, Tomas, McDonald, James I, Kobyra, Julie, Palmer, Erica, Noonepalle, Satish, Villagra, Alejandro, Leitenberg, David, Bollard, Catherine M, Saunthararajah, Yogen, Chiappinelli, Katherine B

“…Novel therapies are urgently needed for ovarian cancer (OC), the fifth deadliest cancer in women. Preclinical work has shown that DNA methyltransferase…”
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Abstract A029: Transposable elements exhibit loss of DNA methylation and increases in transcription in a model of tumorigenesis by Kanholm, Tomas, Rentia, Uzma, Beaty, Melissa Hadley, McDonald, James I., Xie, Wenbing, Baylin, Stephen B., Burns, Kathleen H., Easwaran, Hari, Chiappinelli, Katherine B.

“…Abstract Transposable elements (TEs), including LINEs, SINEs, and LTRs, are typically silenced by epigenetic mechanisms in differentiated healthy tissues…”
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