Search Results - "Rensink, I."

Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity by Tsang-A-Sjoe, M.W.P., Bultink, I.E.M., Korswagen, L.A., van der Horst, A., Rensink, I., de Boer, M., Hamann, D., Voskuyl, A.E., Wouters, D.

“…•Low gene copy number of C4A is associated with increased susceptibility to SLE.•Serositis is associated with low gene copy number of C4A in SLE patients.•A…”
Get full text

Chromatin-Independent Binding of Serum Amyloid P Component to Apoptotic Cells by Familian, Atoosa, Zwart, Bas, Huisman, Han G, Rensink, Irma, Roem, Dorina, Hordijk, Peter L, Aarden, Lucien A, Hack, C. Erik

“…Human serum amyloid P component (SAP) is a glycoprotein structurally belonging to the pentraxin family of proteins, which has a characteristic pentameric…”
Get full text

Sensitive measurement of thrombopoietin by a monoclonal antibody based sandwich enzyme-linked immunosorbent assay by Folman, C C, von dem Borne, A E, Rensink, I H, Gerritsen, W, van der Schoot, C E, de Haas, M, Aarden, L

“…In this report a sensitive enzyme-linked immunosorbent assay (ELISA) for the measurement of plasma thrombopoietin (Tpo) is described that is solely based on…”
Get more information

Characterisation of monoclonal antibodies to human IL-4: application in an IL-4 ELISA and differential inhibition of IL-4 bioactivity on B cells and T cells by van der Pouw Kraan, T, Rensink, I, Aarden, L

“…Five murine monoclonal antibodies, raised against E. coli derived human IL-4, were established. All mAb were also reactive with natural IL-4. Competition ELISA…”
Get more information

A plasma nucleosome releasing factor (NRF) with serine protease activity is instrumental in removal of nucleosomes from secondary necrotic cells by Zeerleder, Sacha, Zwart, Bas, te Velthuis, Henk, Manoe, Rishi, Bulder, Ingrid, Rensink, Irma, Aarden, Lucien A.

“…We observed that interaction of secondary necrotic (sn) cells with human serum or plasma leads to loss of DNA staining. The decrease turned out to be a result…”
Get full text

Both naive and memory T cells can provide help for human IgE production, but with different cytokine requirements by van Kooten, C, van der Pouw Kraan, T, Rensink, I, van Oers, R, Aarden, L

“…Most in vitro systems for the induction of IgE production by human B cells require both IL-4 and the presence of T cells. Little is known about the mechanism…”
Get more information

Complement Activation by Apoptotic Cells Occurs Predominantly via IgM and is Limited to Late Apoptotic (Secondary Necrotic) Cells by Zwart, Bas, Ciurana, Caroline, Rensink, Irma, Manoe, Rishi, Erik Hack, C., Aarden, Lucien A.

“…Apoptotic cells activate complement via various molecular mechanisms. It is not known which of these mechanisms predominate in a physiological environment…”
Get full text

Recombinant Human Monoclonal Antibodies to Ebola Virus by Maruyama, Toshiaki, Parren, Paul W. H. I., Sanchez, Anthony, Rensink, Irma, Rodriguez, Luis L., Khan, Ali S., Peters, C. J., Burton, Dennis R.

“…Human Fab (IgG1κ) phage display libraries were constructed from bone marrow RNA from 2 donors who recovered from infection with Ebola (EBO) virus during the…”
Get full text

Interleukin (IL)-4 production by human T cells: differential regulation of IL-4 vs. IL-2 production by Van der Pouw-Kraan, T, Van Kooten, C, Rensink, I, Aarden, L

“…We have examined the regulation of interleukin (IL)-4 production by human peripheral blood T cells. Production of IL-4 was shown to be regulated differently…”
Get more information

Functional Disparity of Distinct CD28 Response Elements toward Mitogenic Responses by Civil, A, Rensink, I, Aarden, L A, Verweij, C L

“…Activation of T cells through the antigen-specific T-cell receptor in combination with a costimulatory signal results in efficient cytokine gene transcription…”
Get full text

A New Principle for Rapid Immunoassay of Proteins Based on In Situ Precipitate-Enhanced Ellipsometry by Robers, Markus, Rensink, Irma J.A.M., Hack, C. Erik, Aarden, Lucien A., Reutelingsperger, Chris P.M., Glatz, Jan F.C., Hermens, Wim Th

“…A new technique is presented that allows measurement of protein concentrations in the picomolar range with an assay time of only 10–20 min. The method is an…”
Get full text

Recombinant human monoclonal antibodies to Ebola virus: Ebola: the virus and the disease by MARUYAMA, T, PARREN, P. W. H. I, SANCHEZ, A, RENSINK, I, RODRIGUEZ, L. L, KHAN, A. S, PETERS, C. J, BURTON, D. R

Get full text

Effect of IL-4 and IL-6 on the proliferation and differentiation of B-chronic lymphocytic leukemia cells by van Kooten, C, Rensink, I, Aarden, L, van Oers, R

“…The proliferation and differentiation of purified malignant B cells from nine patients with chronic lymphocytic leukemia (B-CLL) were studied in vitro. We have…”
Get more information

Interleukin-4 Inhibits Both Paracrine and Autocrine Tumor Necrosis Factor-α-Induced Proliferation of B Chronic Lymphocytic Leukemia Cells by Kooten, Cees van, Rensink, Irma, Aarden, Lucien, Oers, Rien van

“…The proliferative response of purified malignant B cells from 26 patients with chronic lymphocytic leukemia (CLL) was investigated in vitro. In the majority of…”
Get full text

Monokine production by human T cells; IL-1 alpha production restricted to memory T cells by van Kooten, C, Rensink, I, Pascual-Salcedo, D, van Oers, R, Aarden, L

“…The production of cytokines is a key event of inflammation. In this report we demonstrate that normal human T cells are capable to produce IL-1 alpha, IL-6,…”
Get full text

Nuclear Appearance of a Factor That Binds the CD28 Response Element within the Interleukin-2 Enhancer Correlates with Interleukin-2 Production by Civil, A, Bakker, A, Rensink, I, Doerre, S, Aarden, L A, Verweij, C L

“…Activation of T lymphocytes requires the combined signaling of the T cell receptor and costimulatory molecules such as CD28. The ability of T cells to produce…”
Get full text

Interleukin-4 inhibits both paracrine and autocrine tumor necrosis factor-alpha-induced proliferation of B chronic lymphocytic leukemia cells by van Kooten, C, Rensink, I, Aarden, L, van Oers, R

“…The proliferative response of purified malignant B cells from 26 patients with chronic lymphocytic leukemia (CLL) was investigated in vitro. In the majority of…”
Get full text

Differentiation of purified malignant B cells induced by PMA or by activated normal T cells by van Kooten, C, Rensink, I, Aarden, L, van Oers, R

“…We studied the in vitro differentiation (immunoglobulin production) of purified malignant B cells of 21 patients with different B-cell malignancies, including…”
Get more information

Cytokines and intracellular signals involved in the regulation of B-CLL proliferation by van Kooten, C, Rensink, I, Aarden, L, van Oers, R

“…Cytokines play an important role in the regulation of both normal and malignant B cells. In this paper we give a brief overview of the major cytokines involved…”
Get more information

TNF-alpha induces spreading of B-CLL via the CD11c/CD18 molecule by van Kooten, C, Rensink, I, Aarden, L, van Oers, R

“…Activation of malignant B cells can lead to extensive morphological changes of these cells. A combination of PMA and TNF-alpha can induce adherence of purified…”
Get more information