Search Results - "Renshaw, Mark W"

A Rationally Designed Agonist Antibody Fragment That Functionally Mimics Thrombopoietin by Frederickson, Shana, Renshaw, Mark W., Lin, Bing, Smith, Lynette M., Calveley, Peter, Springhorn, Jeremy P., Johnson, Krista, Wang, Yi, Su, Xiao, Shen, Yamin, Bowdish, Katherine S.

“…By using rational design, antibody fragments (Fabs) that mimic thrombopoietin (TPO) were created. A peptide with cMpl receptorbinding capability was grafted…”
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Focal Adhesion Kinase Mediates the Integrin Signaling Requirement for Growth Factor Activation of MAP Kinase by Renshaw, Mark W., Price, Leo S., Schwartz, Martin Alexander

“…The mitogen-activated protein (MAP) kinase pathway is a critical regulator of cell growth, migration, and differentiation. Growth factor activation of MAP…”
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Suppression of Integrin Activation: A Novel Function of a Ras/Raf-Initiated MAP Kinase Pathway by Hughes, Paul E, Renshaw, Mark W, Pfaff, Martin, Forsyth, Jane, Keivens, Virginia M, Schwartz, Martin A, Ginsberg, Mark H

“…Rapid modulation of ligand binding affinity (“activation”) is a central property of the integrin cell adhesion receptors. Using a screen for suppressors of…”
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The Regulation of Growth and Intracellular Signaling by Integrins by Meredith, Jere E., Winitz, Sim, Lewis, Jean McArthur, Hess, Sibylle, Ren, Xiang-Dong, Renshaw, Mark W., Schwartz, Martin Alexander

“…I. Introduction INTEGRINS are a family of more than 20 different transmembrane receptors composed of noncovalently associated α- and β-subunit heterodimers…”
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Targeting TRAIL death receptor 4 with trivalent DR4 Atrimer complexes by Allen, Joshua E, Ferrini, Roger, Dicker, David T, Batzer, Glenda, Chen, Elise, Oltean, Daniela I, Lin, Bing, Renshaw, Mark W, Kretz-Rommel, Anke, El-Deiry, Wafik S

“…TRAIL is a trimeric protein that potently induces apoptosis in cancer cells by binding to the trimeric death receptors (DR4 or DR5). Death receptors are…”
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Growth factor activation of MAP kinase requires cell adhesion by Renshaw, Mark W., Ren, Xiang-Dong, Schwartz, Martin Alexander

“…The MAP kinase pathway is a major regulator of both normal and oncogenic growth. We report that activation of the MAP kinase ERK2 by serum or purified growth…”
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A step-wise approach significantly enhances protein yield of a rationally-designed agonist antibody fragment in E. coli by Lin, Bing, Renshaw, Mark W., Autote, Kathleen, Smith, Lynette M., Calveley, Peter, Bowdish, Katherine S., Frederickson, Shana

“…Fab59 is a rationally-designed antibody fragment (Fab) that mimics the activity of the cytokine thrombopoietin (TPO). Fab59 activity was initially detected…”
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Involvement of the Small GTPase Rho in Integrin-mediated Activation of Mitogen-activated Protein Kinase by Renshaw, M W, Toksoz, D, Schwartz, M A

“…Engagement and clustering of integrins triggers a number of intracellular signaling events, including activation of the mitogen-activated protein (MAP) kinases…”
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Death effector domain protein PEA-15 potentiates Ras activation of extracellular signal receptor-activated kinase by an adhesion-independent mechanism by Ramos, J W, Hughes, P E, Renshaw, M W, Schwartz, M A, Formstecher, E, Chneiweiss, H, Ginsberg, M H

“…PEA-15 is a small, death effector-domain (DED)-containing protein that was recently demonstrated to inhibit tumor necrosis factor-alpha-induced apoptosis and…”
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S0874 Performance Characteristics of Homogenous Mobility Shift Assay Method Against World Health Organization International Standard for Infliximab Bioactivity and Impact of Dosing Regimens on Exposure by McFarland, Judson, Renshaw, Mark W., Hughes, Patricia, Ho, Jessica, Law, Hong, Jain, Anjali, Schwalbe, Michael, Dervieux, Thierry

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The c-Abl tyrosine kinase contributes to the transient activation of MAP kinase in cells plated on fibronectin by RENSHAW, M. W, LEWIS, J. M, SCHWARTZ, M. A

“…Previous work showed that integrin stimulation triggers activation of the c-Abl tyrosine kinase and its transient localization to focal adhesions. We now…”
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Abstract 1774: Development of potent trimeric DR4 agonist Atrimers with therapeutic potential by Ferrini, Roger, Oltean, Daniela I., Renshaw, Mark W., Chen, Elise, Batzer, Glenda, Gonzalez, Maria J., Lin, Bing, da Silva Correia, Jean, Wild, Martha A., Zhu, Weiguang, Bowdish, Katherine S., Kretz-Rommel, Anke

“…TRAIL death receptor DR4 is a promising therapeutic target in oncology with expression in a wide variety of tumors. DR4 agonists, including TRAIL and…”
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The human leukemia oncogene bcr-abl abrogates the anchorage requirement but not the growth factor requirement for proliferation by Renshaw, Mark W., McWhirter, John R., Wang, Jean Y. J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Rac is required for v-Abl tyrosine kinase to activate mitogenesis by Renshaw, Mark W., Lea-Chou, Elaine, Wang, Jean Y.J.

“…Background: The v-abl oncogene of the Abelson murine leukemia virus (A-MuLV) encodes a cytoplasmic tyrosine kinase that can associate with phosphoinositide…”
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Oncogenic v‐Abl tyrosine kinase can inhibit or stimulate growth, depending on the cell context by Renshaw, M.W., Kipreos, E.T., Albrecht, M.R., Wang, J.Y.

“…The v‐abl oncogene of Abelson murine leukemia virus (A‐MuLV) induces two opposite phenotypes in NIH3T3 cells. In the majority of cells, v‐abl causes a growth…”
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Differential Expression of Type-Specific c-abl mRNAs in Mouse Tissues and Cell Lines by Renshaw, Mark W., Capozza, Michael A., Wang, Jean Y. J.

“…The mammalian c-abl proto-oncogene produces mRNAs with 5′ heterogeneity from two distinct promoters and the alternative splicing of variable 5′ exons. By using…”
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