Search Results - "Rensen, PCN"

Identification of a selective glucocorticoid receptor modulator that prevents both diet‐induced obesity and inflammation by Heuvel, José K, Boon, Mariëtte R, Hengel, Ingmar, Peschier‐van der Put, Emma, Beek, Lianne, Harmelen, Vanessa, Dijk, Ko Willems, Pereira, Alberto M, Hunt, Hazel, Belanoff, Joseph K, Rensen, Patrick C N, Meijer, Onno C

“…Background and Purpose High‐fat diet consumption results in obesity and chronic low‐grade inflammation in adipose tissue. Whereas glucocorticoid receptor (GR)…”
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ApoAV Reduces Plasma Triglycerides by Inhibiting Very Low Density Lipoprotein-Triglyceride (VLDL-TG) Production and Stimulating Lipoprotein Lipase-mediated VLDL-TG Hydrolysis by Schaap, Frank G, Rensen, Patrick C N, Voshol, Peter J, Vrins, Carlos, van der Vliet, Hendrik N, Chamuleau, Robert A F M, Havekes, Louis M, Groen, Albert K, van Dijk, Ko Willems

“…ApoAV has been discovered recently as a novel modifier of triglyceride (TG) metabolism, but the pathways involved are currently unknown. To gain insight into…”
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Cold exposure increases circulating fibroblast growth factor 21 in the evening in males and females by Hoekx, Carlijn A, Martinez-Tellez, Borja, Straat, Maaike E, Verkleij, Magdalena M A, Kemmeren, Mirjam, Kooijman, Sander, Uhrbom, Martin, de Jager, Saskia C A, Rensen, Patrick C N, Boon, Mariëtte R

“…Cold exposure is linked to cardiometabolic benefits. Cold activates brown adipose tissue (BAT), increases energy expenditure, and induces secretion of the…”
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Uptake of postprandial lipoproteins into bone in vivo : Impact on osteoblast function by Niemeier, Andreas, Niedzielska, Dagmara, Secer, Rukiye, Schilling, Arndt, Merkel, Martin, Enrich, Carlos, Rensen, Patrick C.N, Heeren, Joerg

“…Abstract Dietary lipids and lipophilic vitamins are transported by postprandial lipoproteins and are required for bone metabolism. Despite that, it remains…”
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13PHD1 deficiency promotes an atheroprotective metabolic phenotype by Marsch, E, Demandt, J, Theelen, T, Gijbels, MJ, Rensen, PCN, Carmeliet, P, Fisher, EA, Biessen, EAL, Daemen, MJAP, Sluimer, JC

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P430RP105 deficiency aggravates cardiac dysfunction after myocardial infarction in mice by Louwe, MC, Karper, JC, De Vries, MR, Bastiaansen, AJNM, Van Der Hoorn, JWA, Willems Van Dijk, K, Rensen, PCN, Steendijk, P, Smit, JWA, Quax, PHA

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Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL by Berbée, Jimmy F.P., van der Hoogt, Caroline C., Sundararaman, Deepa, Havekes, Louis M., Rensen, Patrick C.N.

“…Studies in humans and mice have shown that increased expression of apolipoprotein C-I (apoC-I) results in combined hyperlipidemia with a more pronounced effect…”
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Determination of the upper size limit for uptake and processing of ligands by the asialoglycoprotein receptor on hepatocytes in vitro and in vivo by Rensen, P C, Sliedregt, L A, Ferns, M, Kieviet, E, van Rossenberg, S M, van Leeuwen, S H, van Berkel, T J, Biessen, E A

“…The asialoglycoprotein receptor (ASGPr) on hepatocytes plays a role in the clearance of desialylated proteins from the serum. Although its sugar preference…”
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Recombinant lipoproteins: lipoprotein-like lipid particles for drug targeting by Rensen, Patrick C.N, de Vrueh, Remco L.A, Kuiper, Johan, Bijsterbosch, Martin K, Biessen, Erik A.L, van Berkel, Theo J.C

“…Lipoproteins are endogenous particles that transport lipids through the blood to various cell types, where they are recognised and taken up via specific…”
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The dual PPARα/γ agonist tesaglitazar blocks progression of pre‐existing atherosclerosis in APOE3Leiden.CETP transgenic mice by Van Der Hoorn, JWA, Jukema, JW, Havekes, LM, Lundholm, E, Camejo, G, Rensen, PCN, Princen, HMG

“…Background and purpose:  We have evaluated the effects of a peroxisome proliferator‐activated receptor (PPAR)α/γ agonist on the progression of pre‐existing…”
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Contribution of Fatty Acids Released From Lipolysis of Plasma Triglycerides to Total Plasma Fatty Acid Flux and Tissue-Specific Fatty Acid Uptake by TEUSINK, Bas, VOSHOL, Peter J, DAHLMANS, Vivian E. H, RENSEN, Patrick C. N, PIJL, Hanno, RAMIJN, Johannes A, HAVEKES, Louis M

“…Contribution of Fatty Acids Released From Lipolysis of Plasma Triglycerides to Total Plasma Fatty Acid Flux and Tissue-Specific Fatty Acid Uptake Bas Teusink 1…”
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CD36 deficiency in mice impairs lipoprotein lipase-mediated triglyceride clearance by Goudriaan, Jeltje R, Boer, Marion A. M. den, Rensen, Patrick C. N, Febbraio, Maria, Kuipers, Folkert, Romijn, Johannes A, Havekes, Louis M, Voshol, Peter J

“…CD36 is involved in high-affinity peripheral FFA uptake. CD36-deficient (cd36⁻[superscript /]⁻) mice exhibit increased plasma FFA and triglyceride (TG) levels…”
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Apolipoprotein E protects against bacterial lipopolysaccharide-induced lethality. A new therapeutic approach to treat gram-negative sepsis by Van Oosten, M, Rensen, P C, Van Amersfoort, E S, Van Eck, M, Van Dam, A M, Breve, J J, Vogel, T, Panet, A, Van Berkel, T J, Kuiper, J

“…Septic shock is the most common cause of death in intensive care units and no effective treatment is available at present. Lipopolysaccharide (LPS) is the…”
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Apolipoprotein CI stimulates the response to lipopolysaccharide and reduces mortality in Gram-negative sepsis by Berbée, Jimmy F.P, Hoogt, Caroline C. van der, Kleemann, Robert, Schippers, Emile F, Kitchens, Richard L, Dissel, Jaap T. van, Bakker-Woudenberg, Irma A.J.M, Havekes, Louis M, Rensen, Patrick C.N

“…Gram-negative sepsis is a major death cause in intensive care units. Accumulating evidence indicates the protective role of plasma lipoproteins such as…”
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Human Neutrophil Peptide 1 Limits Hypercholesterolemia-induced Atherosclerosis by Increasing Hepatic LDL Clearance by Paulin, Nicole, Döring, Yvonne, Kooijman, Sander, Blanchet, Xavier, Viola, Joana R., de Jong, Renske, Mandl, Manuela, Hendrikse, Jeffrey, Schiener, Maximilian, von Hundelshausen, Philipp, Vogt, Anja, Weber, Christian, Bdeir, Khalil, Hofmann, Susanna M., Rensen, Patrick C.N., Drechsler, Maik, Soehnlein, Oliver

“…Increases in plasma LDL-cholesterol have unequivocally been established as a causal risk factor for atherosclerosis. Hence, strategies for lowering of…”
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Scavenger Receptor BI Plays a Role in Facilitating Chylomicron Metabolism by Out, Ruud, Kruijt, J Kar, Rensen, Patrick C N, Hildebrand, Reeni B, de Vos, Paula, Van Eck, Miranda, Van Berkel, Theo J C

“…The function of scavenger receptor class B type I (SR-BI) in mediating the selective uptake of high density lipoprotein (HDL) cholesterol esters is well…”
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Design and Synthesis of Novel N-Acetylgalactosamine-Terminated Glycolipids for Targeting of Lipoproteins to the Hepatic Asialoglycoprotein Receptor by Rensen, Patrick C. N, van Leeuwen, Steven H, Sliedregt, Leo A. J. M, van Berkel, Theo J. C, Biessen, Erik A. L

“…A novel glycolipid has been prepared that contains a cluster glycoside with an unusually high affinity for the asialoglycoprotein receptor (ASGPr) and a bile…”
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Apolipoprotein CI inhibits scavenger receptor BI and increases plasma HDL levels in vivo by de Haan, Willeke, Out, Ruud, Berbée, Jimmy F.P., van der Hoogt, Caroline C., Dijk, Ko Willems van, van Berkel, Theo J.C., Romijn, Johannes A., Wouter Jukema, J., Havekes, Louis M., Rensen, Patrick C.N.

“…Apolipoprotein CI (apoCI) has been suggested to influence HDL metabolism by activation of LCAT and inhibition of HL and CETP. However, the effect of apoCI on…”
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The VLDL receptor plays a major role in chylomicron metabolism by enhancing LPL-mediated triglyceride hydrolysis by Goudriaan, Jeltje R., Santo, Sonia M. S. Espirito, Voshol, Peter J., Teusink, Bas, van Dijk, Ko Willems, van Vlijmen, Bart J.M., Romijn, Johannes A., Havekes, Louis M., Rensen, Patrick C.N.

“…The VLDL receptor (VLDLr) is involved in tissue delivery of VLDL-triglyceride (TG)-derived FFA by facilitating the expression of lipoprotein lipase (LPL)…”
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Apolipoprotein C-III deficiency accelerates triglyceride hydrolysis by lipoprotein lipase in wild-type and apoE knockout mice by Jong, M C, Rensen, P C, Dahlmans, V E, van der Boom, H, van Berkel, T J, Havekes, L M

“…Previous studies with hypertriglyceridemic APOC3 transgenic mice have suggested that apolipoprotein C-III (apoC-III) may inhibit either the apoE-mediated…”
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