Search Results - "Rennick, D M"

Requirement for IL-13 Independently of IL-4 in Experimental Asthma by Grunig, Gabriele, Warnock, Martha, Wakil, Adil E., Venkayya, Rajeev, Brombacher, Frank, Rennick, Donna M., Sheppard, Dean, Mohrs, Markus, Donaldson, Debra D., Locksley, Richard M., Corry, David B.

“…The pathogenesis of asthma reflects, in part, the activity of T cell cytokines. Murine models support participation of interleukin-4 (IL-4) and the IL-4…”
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Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice by SELLON, R. K, TONKONOGY, S, SCHULTZ, M, DIELEMAN, L. A, GRENTHER, W, BALISH, E, RENNICK, D. M, SARTOR, R. B

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Accelerated Alveolar Bone Loss in Mice Lacking Interleukin-10 by Al-Rasheed, A., Scheerens, H., Rennick, D.M., Fletcher, H.M., Tatakis, D.N.

“…Interleukin-10 regulates pro-inflammatory cytokines, including those implicated in alveolar bone resorption. We hypothesized that lack of interleukin-10 leads…”
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Role of IL‐10 in invasive aspergillosis: increased resistance of IL‐10 gene knockout mice to lethal systemic aspergillosis by Clemons, K. V., Grunig, G., Sobel, R. A., Mirels, L. F., Rennick, D. M., Stevens, D. A.

“…IL‐10 is associated with a Th2 response, down‐regulation of a Th1 response and macrophage activation. We assessed the role of IL‐10 during systemic infection…”
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Studies with IL-10-/- mice: an overview by Rennick, Donna M., Fort, Madeline M., Davidson, Natalie J.

“…Our studies have elucidated, in part, the mechanism whereby persistent stimulation by normal enteric antigens leads to the development of chronic enterocolitis…”
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Interleukin 10 : a novel stimulatory factor for mast cells and their progenitors by THOMPSON-SNIPES, L, DHAR, V, BOND, M. W, MOSMANN, T. R, MOORE, K. W, RENNICK, D. M

“…We have characterized the mast cell stimulating activity of murine cytokine synthesis inhibitory factor, referred to as interleukin 10 (IL-10). It was found…”
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Requirements for allergen-induced airway hyperreactivity in T and B cell-deficient mice by Corry, D B, Grünig, G, Hadeiba, H, Kurup, V P, Warnock, M L, Sheppard, D, Rennick, D M, Locksley, R M

“…The pathogenesis of asthma is believed to reflect antigen-induced airway inflammation leading to the recruitment of eosinophils and activation of mast cells…”
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IL-4 Exacerbates Disease in a Th1 Cell Transfer Model of Colitis by Fort, Madeline M, Lesley, Robin, Davidson, Natalie J, Menon, Satish, Brombacher, Frank, Leach, Michael W, Rennick, Donna M

“…IL-4 is associated with Th2-type immune responses and can either inhibit or, in some cases, promote Th1-type responses. We tested the effect of IL-4 treatment…”
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A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12R beta 1 and a Novel Cytokine Receptor Subunit, IL-23R by Parham, C, Chirica, M, Timans, J, Vaisberg, E, Travis, M, Cheung, J, Pflanz, S, Zhang, R, Singh, K P, Vega, F, To, W, Wagner, J, O'Farrell, A, McClanahan, T, Zurawski, S, Hannum, C, Gorman, D, Rennick, D M, Kastelein, R A, de Waal Malefyt, R, Moore, K W

“…IL-23 is a heterodimeric cytokine composed of the IL-12p40 "soluble receptor" subunit and a novel cytokine-like subunit related to IL-12p35, termed p19. Human…”
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Interleukin 4 induces cultured monocytes/macrophages to form giant multinucleated cells by McInnes, A, Rennick, D M

“…Giant multinucleated cells (GMCs) are associated with granulomatous lesions that form in response to various infectious and noninfectious agents. The present…”
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IL-25 Induces IL-4, IL-5, and IL-13 and Th2-Associated Pathologies In Vivo by Fort, Madeline M., Cheung, Jeanne, Yen, David, Li, Joana, Zurawski, Sandra M., Lo, Sylvia, Menon, Satish, Clifford, Teresa, Hunte, Brisdell, Lesley, Robin, Muchamuel, Tony, Hurst, Stephen D., Zurawski, Gerard, Leach, Michael W., Gorman, Daniel M., Rennick, Donna M.

“…We have characterized a cytokine produced by Th2 cells, designated as IL-25. Infusion of mice with IL-25 induced IL-4, IL-5, and IL-13 gene expression. The…”
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Isolation and Characterization of Lymphokine cDNA Clones Encoding Mouse and Human IgA-Enhancing Factor and Eosinophil Colony-Stimulating Factor Activities: Relationship to Interleukin 5 by Yokota, Takashi, Coffman, Robert L., Hagiwara, Hajime, Rennick, Donna M., Takebe, Yutaka, Yokota, Kyoko, Gemmell, Lorraine, Shrader, Barbara, Yang, Gloria, Meyerson, Patricia, Luh, Jeanne, Hoy, Pamala, Pène, Jérome, Brière, Francine, Spits, Hergen, Banchereau, Jacques, De Vries, Jan, Lee, Frank D., Arai, Naoko, Arai, Ken-Ichi

“…Conditioned medium from the Con A-treated mouse helper T-cell clone Ly1+2-/9 contains activities that enhance the production of IgA by mouse B cells and induce…”
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Characterization of a Murine Lymphokine Distinct from Interleukin 2 and Interleukin 3 (IL-3) Possessing a T-Cell Growth Factor Activity and a Mast-Cell Growth Factor Activity That Synergizes with IL-3 by Smith, Craig A., Rennick, Donna M.

“…Murine mast-cell and T-cell growth factor activities, distinct from interleukins 3 and 2 (IL-3 and IL-2), have been identified and partially purified from the…”
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Endogenous Inhibition of Antimycobacterial Immunity by IL‐10 Varies between Mycobacterial Species by Roach, D. R., Martin, E., Bean, A. G. D., Rennick, D. M., Briscoe, H., Britton, W. J.

“…Interleukin (IL)‐10 is an immunoregulatory cytokine that inhibits both Th1‐like T cell responses and macrophage activation. Deficiency of IL‐10 has been…”
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Blockade of Costimulation Prevents Infection-Induced Immunopathology in Interleukin-10-Deficient Mice by VILLEGAS, E. N, WILLE, U, CRAIG, L, LINSLEY, P. S, RENNICK, D. M, PEACH, R, HUNTER, C. A

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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The Role of IL-10 in Inflammatory Bowel Disease: "Of Mice and Men" by Leach, Michael W., Davidson, Natalie J., Fort, Madeline M., Powrie, Fiona, Rennick, Donna M.

“…Inflammatory bowel disease (IBD) is a generic term typically used to describe a group of idiopathic inflammatory intestinal conditions in humans that are…”
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Lessons from genetically engineered animal models. XII. IL-10-deficient (IL-10(-/-) mice and intestinal inflammation by Rennick, D M, Fort, M M

“…Interleukin (IL)-10(-/-) mice spontaneously develop intestinal inflammation characterized by discontinuous transmural lesions affecting the small and large…”
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A cloned MCGF cDNA encodes a multilineage hematopoietic growth factor: multiple activities of interleukin 3 by Rennick, DM, Lee, FD, Yokota, T, Arai, KI, Cantor, H, Nabel, GJ

“…We recently isolated from a mouse T cell cDNA library a full-length clone that encodes a mast cell growth factor (1). On the basis of sequence homologies, this…”
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IL-12, but not IFN-gamma, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice by Davidson, N J, Hudak, S A, Lesley, R E, Menon, S, Leach, M W, Rennick, D M

“…IL-10-deficient (IL-10(-/-)) mice develop chronic enterocolitis mediated by CD4+ Th1 cells producing IFN-gamma. Because IL-12 can promote Th1 development and…”
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T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice by Davidson, N J, Leach, M W, Fort, M M, Thompson-Snipes, L, Kühn, R, Müller, W, Berg, D J, Rennick, D M

“…Mice rendered deficient in the production of interleukin 10 (IL-10-/-) develop a chronic inflammatory bowel disease (IBD) that predominates in the colon and…”
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