The Rewarding Properties of NMDA and MK-801 (Dizocilpine) as Indexed by the Conditioned Place Preference Paradigm

N-Methyl- d-aspartate (NMDA) ([R]-2-[Methylamino]succinic acid) is a specific excitatory amino acid. Two experiments were conducted to determine the rewarding properties of this compound using the conditioned place preference paradigm. In the first experiment, 40 male Sprague–Dawley rats received pl...

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Bibliographic Details
Published in:	Pharmacology, biochemistry and behavior Vol. 64; no. 3; pp. 591 - 595
Main Authors:	Panos, John J, Rademacher, David J, Renner, Staci L, Steinpreis, Rhea E
Format:	Journal Article Conference Proceeding
Language:	English
Published:	New York, NY Elsevier Inc 01-11-1999 Elsevier Science
Subjects:	Animals Biological and medical sciences Conditioned place preference Conditioning, Operant - drug effects Dizocilpine Dizocilpine Maleate - pharmacology Excitatory Amino Acid Agonists - pharmacology Excitatory Amino Acid Antagonists - pharmacology Glutamatergic system (aspartate and other excitatory aminoacids) Male Medical sciences MK-801 N-Methylaspartate - pharmacology Neuropharmacology Neurotransmitters. Neurotransmission. Receptors NMDA Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Receptor antagonist Reward Reward mechanisms Self Administration NMDA MK-801 Receptor antagonist Reward mechanisms Conditioned place preference Dizocilpine Agonist Drug combination Intraperitoneal administration Rat Rodentia Instrumental conditioning Biological activity Dose activity relation Learning Vertebrata Mammalia Animal Excitatory aminoacid Drug interaction Antagonist Reward NMDA receptor Chemical stimulus
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Summary:	N-Methyl- d-aspartate (NMDA) ([R]-2-[Methylamino]succinic acid) is a specific excitatory amino acid. Two experiments were conducted to determine the rewarding properties of this compound using the conditioned place preference paradigm. In the first experiment, 40 male Sprague–Dawley rats received place preference conditioning for a 4 day period. The conditioned place preference apparatus consisted of two chambers with distinct visual and tactile cues, separated by a removable door. On days 2 and 4, rats were systemically administered NMDA (1.0, 15.0, and 30.0 mg/kg) paired with one chamber. On days 3 and 5, rats were systemically administered saline paired with the other chamber. Day 6 was the test day, and the rat was allowed free run of the entire apparatus in a drug-free state. Time spent in each side of the apparatus was computer recorded. NMDA produced a significant increase in the amount of time spent on the side previously paired with drug for 15.0 and 30.0, but not 1.0 mg/kg NMDA. In the second experiment, systemic administration of NMDA (30.0 mg/kg) paired with the noncompetitive NMDA receptor antagonist, MK-801 (0.5 mg/kg), resulted in neither place preference nor place aversion.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0091-3057 1873-5177
DOI:	10.1016/S0091-3057(99)00155-0