Search Results - "Rennard, Rachel"

Comprehensive optimization of a single-chain variable domain antibody fragment as a targeting ligand for a cytotoxic nanoparticle by Zhang, Kathy, Geddie, Melissa L, Kohli, Neeraj, Kornaga, Tad, Kirpotin, Dmitri B, Jiao, Yang, Rennard, Rachel, Drummond, Daryl C, Nielsen, Ulrik B, Xu, Lihui, Lugovskoy, Alexey A

“…Antibody-targeted nanoparticles have the potential to significantly increase the therapeutic index of cytotoxic anti-cancer therapies by directing them to…”
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A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity by Dong, Jianying, Sereno, Arlene, Aivazian, Dikran, Langley, Emma, Miller, Brian R., Snyder, William B, Chan, Eric, Cantele, Matt, Morena, Ronald, Joseph, Ingrid B.J.K., Boccia, Antonio, Virata, Cyrus, Gamez, James, Yco, Grace, Favis, Michael, Wu, Xiufeng, Graff, Christilyn P., Wang, Qin, Rohde, Ellen, Rennard, Rachel, Berquist, Lisa, Huang, Flora, Zhang, Ying, Gao, Sharon X., Ho, Steffan N., Demarest, Stephen J., Reff, Mitchell E., Hariharan, Kandasamy, Glaser, Scott M.

“…The epidermal growth factor receptor (EGFR) and the type I insulin-like growth factor receptor (IGF-1R) are two cell surface receptor tyrosine kinases known to…”
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Antibodies directed to α6β4 highlight the adhesive and signaling functions of the integrin in breast cancer cell lines by Gabarra, Veronica, Cho, Samuel, Ramirez, Miriam, Ren, Yan, Chen, Ling Ling, Cheung, Anne, Cao, Xianjun, Rennard, Rachel, Unruh, Kelsey R., Graff, Christilyn P., Browning, Beth, Huet, Heather, McLachlan, Karen

“…Integrin α6β4 signaling interactions have been implicated in tumor progression, and β4 expression has been linked to poor prognosis in certain breast cancer…”
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Characterization of Inhibitory Anti-insulin-like Growth Factor Receptor Antibodies with Different Epitope Specificity and Ligand-blocking Properties by Doern, Adam, Cao, Xianjun, Sereno, Arlene, Reyes, Christopher L., Altshuler, Angelina, Huang, Flora, Hession, Cathy, Flavier, Albert, Favis, Michael, Tran, Hon, Ailor, Eric, Levesque, Melissa, Murphy, Tracey, Berquist, Lisa, Tamraz, Susan, Snipas, Tracey, Garber, Ellen, Shestowsky, William S., Rennard, Rachel, Graff, Christilyn P., Wu, Xiufeng, Snyder, William, Cole, Lindsay, Gregson, David, Shields, Michael, Ho, Steffan N., Reff, Mitchell E., Glaser, Scott M., Dong, Jianying, Demarest, Stephen J., Hariharan, Kandasamy

“…Therapeutic antibodies directed against the type 1 insulin-like growth factor receptor (IGF-1R) have recently gained significant momentum in the clinic because…”
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The Impact of Competition on Performance in a Political System by Rennard, Rachel

“…The impact of competition inherent in political campaigns on performance was investigated in a qualitative, inductive study exploring the experiences of…”
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MM-141, an IGF-IR- and ErbB3-directed bispecific antibody, overcomes network adaptations that limit activity of IGF-IR inhibitors by Fitzgerald, Jonathan B, Johnson, Bryan W, Baum, Jason, Adams, Sharlene, Iadevaia, Sergio, Tang, Jian, Rimkunas, Victoria, Xu, Lihui, Kohli, Neeraj, Rennard, Rachel, Razlog, Maja, Jiao, Yang, Harms, Brian D, Olivier, Jr, Kenneth J, Schoeberl, Birgit, Nielsen, Ulrik B, Lugovskoy, Alexey A

“…Although inhibition of the insulin-like growth factor (IGF) signaling pathway was expected to eliminate a key resistance mechanism for EGF receptor…”
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ANGPTL7 and Its Role in IOP and Glaucoma by Brown, Suzette Farber-Katz, Nguyen, Hien, Mzyk, Philip, De Ieso, Michael L, Unser, Andrea M, Brown, Ian, Ramesh, Pujhitha, Afzaal, Hira, Ahmed, Feryan, Torrejon, Karen Y, Nhan, Alan, Markrush, Dalton, Daly, Tom, Knecht, Ellie, McConaughy, William, Halmos, Sara, Liu, Zhiquan Lucy, Rennard, Rachel, Peterson, Andrew, Stamer, W Daniel

“…Loss-of-function variants in the ANGPTL7 gene are associated with protection from glaucoma and reduced intraocular pressure (IOP). We investigated the role of…”
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Abstract 3239: CTX-5861 mediated SIRPα blockade combines with tumor targeting antibodies, checkpoint blockade and/or CD137 agonism to elicit curative anti-tumor activity in syngeneic mouse models by Eskiocak, Ugur, Guzman, Wilson, Daly, Thomas, Nelson, Allison, Bakhru, Pearl, Lajoie, Jason, Haserlat, Sara, Ottinger, Samantha, Liu, Lucy, Oliphant, Amanda, Leung, Alan, Hemashettar, Girish, Rennard, Rachel, Wolf, Benjamin, Draghi, Monia, Schmidt, Michael, Tighe, Robert

“…Abstract Blockade of inhibitory checkpoint pathways, such as PD-1/PD-L1 and CTLA-4, has provided significant benefit to subsets of patients and changed the…”
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Improving the developability of an anti-EphA2 single-chain variable fragment for nanoparticle targeting by Geddie, Melissa L, Kohli, Neeraj, Kirpotin, Dmitri B, Razlog, Maja, Jiao, Yang, Kornaga, Tad, Rennard, Rachel, Xu, Lihui, Schoerberl, Birgit, Marks, James D, Drummond, Daryl C, Lugovskoy, Alexey A

“…Antibody-targeted nanoparticles have great promise as anti-cancer drugs; however, substantial developmental challenges of antibody modules prevent many…”
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Rapid optimization and prototyping for therapeutic antibody-like molecules by Xu, Lihui, Kohli, Neeraj, Rennard, Rachel, Jiao, Yang, Razlog, Maja, Zhang, Kathy, Baum, Jason, Johnson, Bryan, Tang, Jian, Schoeberl, Birgit, Fitzgerald, Jonathan, Nielsen, Ulrik, Lugovskoy, Alexey A.

“…Multispecific antibody-like molecules have the potential to advance the standard-of-care in many human diseases. The design of therapeutic molecules in this…”
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T Cell, Ig Domain, Mucin Domain-2 Gene-Deficient Mice Reveal a Novel Mechanism for the Regulation of Th2 Immune Responses and Airway Inflammation by Rennert, Paul D, Ichimura, Takaharu, Sizing, Irene D, Bailly, Veronique, Li, Zhifang, Rennard, Rachel, McCoon, Patricia, Pablo, Lourdes, Miklasz, Steven, Tarilonte, Leticia, Bonventre, Joseph V

“…The development of asthma and other atopic diseases is influenced by cytokines produced by Th2 effector T cells. How effector T cell responses are regulated…”
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Epitope-Dependent Effect of Anti-Murine TIM-1 Monoclonal Antibodies on T Cell Activity and Lung Immune Responses by Sizing, Irene D, Bailly, Veronique, McCoon, Patricia, Chang, Wenjie, Rao, Sambasiva, Pablo, Lourdes, Rennard, Rachel, Walsh, Meghan, Li, Zhifang, Zafari, Mohammad, Dobles, Max, Tarilonte, Leticia, Miklasz, Steven, Majeau, Gerard, Godbout, Kevin, Scott, Martin L, Rennert, Paul D

“…The TAPR locus containing the TIM gene family is implicated in the development of atopic inflammation in mouse, and TIM-1 allelic variation has been associated…”
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Abstract 2719: MM-141, a novel bispecific antibody co-targeting IGF-1R and ErbB3, blocks ligand-induced signaling and demonstrates antitumor activity by Baum, Jason, Johnson, Bryan, Adams, Sharlene, Tang, Jian, Kohli, Neeraj, Rennard, Rachel, Sundararajan, Pragalath, Xu, Lihui, Jiao, Yang, Schoeberl, Birgit, Nielsen, Ulrik, Fitzgerald, Jonathan, Lugovskoy, Alexey

“…Abstract Monoclonal antibodies have significantly advanced our ability to treat cancer, but most patients do not show durable responses to therapy. This, in…”
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Abstract B205: Therapeutically targeting redundant, growth factor-induced prosurvival signaling with MM-141, a novel bispecific antibody targeting IGF-1R and ErbB3 by Lugovskoy, Alexey, Johnson, Bryan, Baum, Jason, Adams, Sharlene, Tang, Jian, Kohli, Neeraj, Rennard, Rachel, Xu, Lihui, Jiao, Yang, Nilesen, Ulrik, Fitzgerald, Jonathan

“…Abstract Monoclonal antibodies have significantly advanced our ability to treat cancer, but most patients do not have durable responses to therapy. We find…”
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Characterization of Inhibitory Anti-insulin-like Growth Factor Receptor Antibodies with Different Epitope Specificity and Ligand-blocking Properties: IMPLICATIONS FOR MECHANISM OF ACTION IN VIVO by Doern, Adam, Cao, Xianjun, Sereno, Arlene, Reyes, Christopher L, Altshuler, Angelina, Huang, Flora, Hession, Cathy, Flavier, Albert, Favis, Michael, Tran, Hon, Ailor, Eric, Levesque, Melissa, Murphy, Tracey, Berquist, Lisa, Tamraz, Susan, Snipas, Tracey, Garber, Ellen, Shestowsky, William S, Rennard, Rachel, Graff, Christilyn P, Wu, Xiufeng, Snyder, William, Cole, Lindsay, Gregson, David, Shields, Michael, Ho, Steffan N, Reff, Mitchell E, Glaser, Scott M, Dong, Jianying, Demarest, Stephen J, Hariharan, Kandasamy

“…Therapeutic antibodies directed against the type 1 insulin-like growth factor receptor (IGF-1R) have recently gained significant momentum in the clinic because…”
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Widespread Correction of Lysosomal Storage Following Intrahepatic Injection of a Recombinant Adeno-associated Virus in the Adult MPS VII Mouse by Sferra, Thomas J, Backstrom, Kristin, Wang, Chuansong, Rennard, Rachel, Miller, Matt, Hu, Yan

“…Mucopolysaccharidosis type VII is a lysosomal storage disease caused by deficiency of the acid hydrolase beta-glucuronidase. MPS VII mice develop progressive…”
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Function of the Neurospora crassa mitochondrial tyrosyl-tRNA synthetase in RNA splicing. Role of the idiosyncratic N-terminal extension and different modes of interaction with different group I introns by Mohr, Georg, Rennard, Rachel, Cherniack, Andrew D, Stryker, John, Lambowitz, Alan M

“…The Neurospora crassa mitochondrial tyrosyl-tRNA synthetase (CYT-18 protein) promotes the splicing of group I introns by helping the intron RNA fold into the…”
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Recombinant adeno-associated virus-mediated correction of lysosomal storage within the central nervous system of the adult mucopolysaccharidosis type VII mouse by Sferra, T J, Qu, G, McNeely, D, Rennard, R, Clark, K R, Lo, W D, Johnson, P R

“…The central nervous system (CNS) is a predominant site of involvement in several lysosomal storage diseases (LSDs); and for many patients, these diseases are…”
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Antibodies directed to alpha6beta4 highlight the adhesive and signaling functions of the integrin in breast cancer cell lines by Gabarra, Veronica, Cho, Samuel, Ramirez, Miriam, Ren, Yan, Chen, Ling Ling, Cheung, Anne, Cao, Xianjun, Rennard, Rachel, Unruh, Kelsey R, Graff, Christilyn P, Browning, Beth, Huet, Heather A, McLachlan, Karen

“…Integrin alpha6beta4 signaling interactions have been implicated in tumor progression, and beta4 expression has been linked to poor prognosis in certain breast…”
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Characterization of Neurospora mitochondrial group I introns reveals different CYT-18 dependent and independent splicing strategies and an alternative 3' splice site for an intron ORF by Wallweber, G J, Mohr, S, Rennard, R, Caprara, M G, Lambowitz, A M

“…The Neurospora crassa mitochondrial tyrosyl-tRNA synthetase (CYT-18 protein) functions in splicing the N. crassa mitochondrial large rRNA intron by stabilizing…”
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