Search Results - "Renger, J."

Discovery and development of orexin receptor antagonists as therapeutics for insomnia by Winrow, C J, Renger, J J

“…Insomnia persistently affects the quality and quantity of sleep. Currently approved treatments for insomnia primarily target γ‐aminobutyric acid‐A (GABA‐A)…”
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Presynaptic Cav3.2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons by Jacus, Megan O, Uebele, Victor N, Renger, John J, Todorovic, Slobodan M

“…It is generally accepted that presynaptic transmitter release is mainly regulated by subtypes of neuronal high-voltage-activated Ca(2+) channels. Here for the…”
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Internalized Tau Oligomers Cause Neurodegeneration by Inducing Accumulation of Pathogenic Tau in Human Neurons Derived from Induced Pluripotent Stem Cells by Usenovic, Marija, Niroomand, Shahriar, Drolet, Robert E, Yao, Lihang, Gaspar, Renee C, Hatcher, Nathan G, Schachter, Joel, Renger, John J, Parmentier-Batteur, Sophie

“…Neuronal inclusions of hyperphosphorylated and aggregated tau protein are a pathological hallmark of several neurodegenerative tauopathies, including…”
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Three-dimensional manipulation with scanning near-field optical nanotweezers by Berthelot, J., Aćimović, S. S., Juan, M. L., Kreuzer, M. P., Renger, J., Quidant, R.

“…Recent advances in nanotechnologies have prompted the need for tools to accurately and non-invasively manipulate individual nano-objects 1 . Among the possible…”
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The Discovery of Suvorexant, the First Orexin Receptor Drug for Insomnia by Coleman, Paul J, Gotter, Anthony L, Herring, W. Joseph, Winrow, Christopher J, Renger, John J

“…Historically, pharmacological therapies have used mechanisms such as γ-aminobutyric acid A (GABA A ) receptor potentiation to drive sleep through broad…”
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Essential thalamic contribution to slow waves of natural sleep by David, François, Schmiedt, Joscha T, Taylor, Hannah L, Orban, Gergely, Di Giovanni, Giuseppe, Uebele, Victor N, Renger, John J, Lambert, Régis C, Leresche, Nathalie, Crunelli, Vincenzo

“…Slow waves represent one of the prominent EEG signatures of non-rapid eye movement (non-REM) sleep and are thought to play an important role in the cellular…”
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Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors by Yin, Jie, Babaoglu, Kerim, Brautigam, Chad A, Clark, Lindsay, Shao, Zhenhua, Scheuermann, Thomas H, Harrell, Charles M, Gotter, Anthony L, Roecker, Anthony J, Winrow, Christopher J, Renger, John J, Coleman, Paul J, Rosenbaum, Daniel M

“…Human orexin receptors (hOX 1 R and hOX 2 R) are GPCRs involved in sleep regulation. Structures of hOX 1 R bound to a selective antagonist or to a dual…”
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Intracellular clusterin interacts with brain isoforms of the bridging integrator 1 and with the microtubule-associated protein Tau in Alzheimer's disease by Zhou, Yuan, Hayashi, Ikuo, Wong, Jacky, Tugusheva, Katherine, Renger, John J, Zerbinatti, Celina

“…Sporadic or late-onset Alzheimer's disease (AD) is expected to affect 50% of individuals reaching 85 years of age. The most significant genetic risk factor for…”
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International Union of Basic and Clinical Pharmacology. LXXXVI. Orexin receptor function, nomenclature and pharmacology by Gotter, Anthony L, Webber, Andrea L, Coleman, Paul J, Renger, John J, Winrow, Christopher J

“…Orexin signaling is essential for normal regulation of arousal and behavioral state control and represents an attractive target for therapeutics combating…”
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Deep-subwavelength imaging of the modal dispersion of light by Sapienza, R., Coenen, T., Renger, J., Kuttge, M., van Hulst, N. F., Polman, A.

“…Numerous optical technologies and quantum optical devices rely on the controlled coupling of a local emitter to its photonic environment, which is governed by…”
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Orexin 2 receptor regulation of the hypothalamic-pituitary-adrenal (HPA) response to acute and repeated stress by Grafe, Laura A, Eacret, Darrell, Luz, Sandra, Gotter, Anthony L, Renger, John J, Winrow, Chris J, Bhatnagar, Seema

“…Highlights • Orexin activation and levels in csf decrease throughout repeated restraint. • OX2 R promotes HPA response to acute stress. • When orexin levels…”
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Presynaptic HCN1 channels regulate CaV3.2 activity and neurotransmission at select cortical synapses by Huang, Zhuo, Lujan, Rafael, Kadurin, Ivan, Uebele, Victor N, Renger, John J, Dolphin, Annette C, Shah, Mala M

“…The authors find that hyperpolarization-activated cyclic nucleotide–gated 1 (HCN1) channel subunits are localized to the active zone of asymmetric synaptic…”
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Aging African green monkeys manifest transcriptional, pathological, and cognitive hallmarks of human Alzheimer's disease by Cramer, Paige E., Gentzel, Renee C., Tanis, Keith Q., Vardigan, Joshua, Wang, Yi, Connolly, Brett, Manfre, Philip, Lodge, Kenneth, Renger, John J., Zerbinatti, Celina, Uslaner, Jason M.

“…While many preclinical models of Alzheimer's disease (AD) have been reported, none fully recapitulate the disease. In an effort to identify an appropriate…”
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GABAergic synaptic transmission triggers action potentials in thalamic reticular nucleus neurons by Sun, Yan-Gang, Wu, Chia-Shan, Renger, John J, Uebele, Victor N, Lu, Hui-Chen, Beierlein, Michael

“…GABAergic neurons in the thalamic reticular nucleus (TRN) form powerful inhibitory connections with several dorsal thalamic nuclei, thereby controlling…”
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Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia by Cox, Christopher D, Breslin, Michael J, Whitman, David B, Schreier, John D, McGaughey, Georgia B, Bogusky, Michael J, Roecker, Anthony J, Mercer, Swati P, Bednar, Rodney A, Lemaire, Wei, Bruno, Joseph G, Reiss, Duane R, Harrell, C. Meacham, Murphy, Kathy L, Garson, Susan L, Doran, Scott M, Prueksaritanont, Thomayant, Anderson, Wayne B, Tang, Cuyue, Roller, Shane, Cabalu, Tamara D, Cui, Donghui, Hartman, George D, Young, Steven D, Koblan, Ken S, Winrow, Christopher J, Renger, John J, Coleman, Paul J

“…Despite increased understanding of the biological basis for sleep control in the brain, few novel mechanisms for the treatment of insomnia have been identified…”
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Calcineurin signaling mediates activity-dependent relocation of the axon initial segment by Evans, Mark D, Sammons, Rosanna P, Lebron, Sabrina, Dumitrescu, Adna S, Watkins, Thomas B K, Uebele, Victor N, Renger, John J, Grubb, Matthew S

“…The axon initial segment (AIS) is a specialized neuronal subcompartment located at the beginning of the axon that is crucially involved in both the generation…”
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Promotion of Sleep by Suvorexant-A Novel Dual Orexin Receptor Antagonist by Winrow, Christopher J., Gotter, Anthony L., Cox, Christopher D., Doran, Scott M., Tannenbaum, Pamela L., Breslin, Michael J., Garson, Susan L., Fox, Steven V., Harrell, Charles M., Stevens, Joanne, Reiss, Duane R., Cui, Donghui, Coleman, Paul J., Renger, John J.

“…Orexins/hypocretins are key neuropeptides responsible for regulating central arousal and reward circuits. Two receptors respond to orexin signaling, orexin 1…”
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A Comparative Study on the Lysosomal Cation Channel TMEM175 Using Automated Whole-Cell Patch-Clamp, Lysosomal Patch-Clamp, and Solid Supported Membrane-Based Electrophysiology: Functional Characterization and High-Throughput Screening Assay Development by Bazzone, Andre, Barthmes, Maria, George, Cecilia, Brinkwirth, Nina, Zerlotti, Rocco, Prinz, Valentin, Cole, Kim, Friis, Søren, Dickson, Alexander, Rice, Simon, Lim, Jongwon, Fern Toh, May, Mohammadi, Milad, Pau, Davide, Stone, David J., Renger, John J., Fertig, Niels

“…The lysosomal cation channel TMEM175 is a Parkinson’s disease-related protein and a promising drug target. Unlike whole-cell automated patch-clamp (APC),…”
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Improved cognition without adverse effects: novel M1 muscarinic potentiator compares favorably to donepezil and xanomeline in rhesus monkey by Vardigan, Joshua D., Cannon, Christopher E., Puri, Vanita, Dancho, Mandy, Koser, AmyJo, Wittmann, Marion, Kuduk, Scott D., Renger, John J., Uslaner, Jason M.

“…Rationale The standards of care for Alzheimer’s disease, acetylcholinesterase inhibitors such as donepezil (Aricept®), are dose-limited due to adverse…”
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Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man by Gotter, Anthony L., Forman, Mark S., Harrell, Charles M., Stevens, Joanne, Svetnik, Vladimir, Yee, Ka Lai, Li, Xiaodong, Roecker, Anthony J., Fox, Steven V., Tannenbaum, Pamela L., Garson, Susan L., Lepeleire, Inge De, Calder, Nicole, Rosen, Laura, Struyk, Arie, Coleman, Paul J., Herring, W. Joseph, Renger, John J., Winrow, Christopher J.

“…Orexin neuropeptides regulate sleep/wake through orexin receptors (OX 1 R, OX 2 R); OX 2 R is the predominant mediator of arousal promotion. The potential for…”
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