Search Results - "Renešová, Nicol"
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3,5,7-Substituted Pyrazolo[4,3‑d]Pyrimidine Inhibitors of Cyclin-Dependent Kinases and Cyclin K Degraders
Published in Journal of medicinal chemistry (14-07-2022)“…3,5,7-Trisubstituted pyrazolo[4,3-d]pyrimidines have been identified as potent inhibitors of cyclin-dependent kinases (CDKs), which are established drug…”
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Cell cycle and differentiation of Sca-1+ and Sca-1− hematopoietic stem and progenitor cells
Published in Cell cycle (Georgetown, Tex.) (18-08-2018)“…Hematopoietic stem and progenitor cells (HSPCs) are crucial for lifelong blood cell production. We analyzed the cell cycle and cell production rate in HSPCs in…”
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Altered Erythro-Myeloid Progenitor Cells Are Highly Expanded in Intensively Regenerating Hematopoiesis
Published in Frontiers in cell and developmental biology (25-02-2020)“…Regeneration of severely damaged adult tissues is currently only partially understood. Hematopoietic tissue provides a unique opportunity to study tissue…”
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BH3 Mimetics in Hematologic Malignancies
Published in International journal of molecular sciences (21-09-2021)“…Hematologic malignancies (HM) comprise diverse cancers of lymphoid and myeloid origin, including lymphomas (approx. 40%), chronic lymphocytic leukemia (CLL,…”
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Targeted Drug Delivery and Theranostic Strategies in Malignant Lymphomas
Published in Cancers (26-01-2022)“…Malignant lymphomas represent the most common type of hematologic malignancies. The first clinically approved TDD modalities in lymphoma patients were…”
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Complex genetic and histopathological study of 15 patient-derived xenografts of aggressive lymphomas
Published in Laboratory investigation (01-09-2022)“…Non-Hodgkin lymphomas (NHL) represent the most common hematologic malignancies. Patient-derived xenografts (PDXs) are used for various aspects of translational…”
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biomarker Driven Strategies for Targeted Elimination of Hypoxia Adapted Lymphoma Cells
Published in Blood (02-11-2023)“…Large body of evidence suggests that hypoxia drives aggressive molecular features irrespective of cancer type. Non-Hodgkin lymphomas (NHL) are the most common…”
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Complex genetic and histopathological study of 15 patient-derived xenografts of aggressive lymphomas
Published in Laboratory investigation (01-09-2022)“…Non-Hodgkin lymphomas (NHL) represent the most common hematologic malignancies. Patient-derived xenografts (PDXs) are used for various aspects of translational…”
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Anti-apoptotic MCL1 Protein Represents Critical Survival Molecule for Most Burkitt Lymphomas and BCL2-negative Diffuse Large B-cell Lymphomas
Published in Molecular cancer therapeutics (01-01-2022)“…The pro-survival MCL1 protein is overexpressed in many cancers, including B-cell non-Hodgkin lymphomas (B-NHL). S63845 is a highly specific inhibitor of MCL1…”
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Hierarchy of Sca-1positive and Sca-1negative hematopoietic stem and progenitor cells and their contribution to blood cell production
Published in Experimental hematology (01-09-2017)Get full text
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