Search Results - "Rene, Quevedo"

Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity by Hezaveh, Kebria, Shinde, Rahul S, Klötgen, Andreas, Halaby, Marie Jo, Lamorte, Sara, Ciudad, M Teresa, Quevedo, Rene, Neufeld, Luke, Liu, Zhe Qi, Jin, Robbie, Grünwald, Barbara T, Foerster, Elisabeth G, Chaharlangi, Danica, Guo, Mengdi, Makhijani, Priya, Zhang, Xin, Pugh, Trevor J, Pinto, Devanand M, Co, Ileana L, McGuigan, Alison P, Jang, Gun Ho, Khokha, Rama, Ohashi, Pamela S, O'Kane, Grainne M, Gallinger, Steven, Navarre, William W, Maughan, Heather, Philpott, Dana J, Brooks, David G, McGaha, Tracy L

“…The aryl hydrocarbon receptor (AhR) is a sensor of products of tryptophan metabolism and a potent modulator of immunity. Here, we examined the impact of AhR in…”
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Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling by Loganathan, Sampath K, Schleicher, Krista, Malik, Ahmad, Quevedo, Rene, Langille, Ellen, Teng, Katie, Oh, Robin H, Rathod, Bhavisha, Tsai, Ricky, Samavarchi-Tehrani, Payman, Pugh, Trevor J, Gingras, Anne-Claude, Schramek, Daniel

“…In most human cancers, only a few genes are mutated at high frequencies; most are mutated at low frequencies. The functional consequences of these recurrent…”
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KSR1 Knockout Mouse Model Demonstrates MAPK Pathway's Key Role in Cisplatin- and Noise-induced Hearing Loss by Ingersoll, Matthew A, Lutze, Richard D, Kelmann, Regina G, Kresock, Daniel F, Marsh, Jordan D, Quevedo, Rene V, Zuo, Jian, Teitz, Tal

“…Hearing loss is a major disability in everyday life and therapeutic interventions to protect hearing would benefit a large portion of the world population…”
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Somatic BRCA1/2 Recovery as a Resistance Mechanism After Exceptional Response to Poly (ADP-ribose) Polymerase Inhibition by Lheureux, Stephanie, Bruce, Jeff P, Burnier, Julia V, Karakasis, Katherine, Shaw, Patricia A, Clarke, Blaise A, Yang, S Y Cindy, Quevedo, Rene, Li, Tiantian, Dowar, Mark, Bowering, Valerie, Pugh, Trevor J, Oza, Amit M

“…Purpose Durable and long-term responses to the poly (ADP-ribose) polymerase inhibitor olaparib are observed in patients without BRCA1/2 mutations. However,…”
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Gene isoforms as expression-based biomarkers predictive of drug response in vitro by Safikhani, Zhaleh, Smirnov, Petr, Thu, Kelsie L., Silvester, Jennifer, El-Hachem, Nehme, Quevedo, Rene, Lupien, Mathieu, Mak, Tak W., Cescon, David, Haibe-Kains, Benjamin

“…Next-generation sequencing technologies have recently been used in pharmacogenomic studies to characterize large panels of cancer cell lines at the genomic and…”
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Landscape of genomic alterations in high-grade serous ovarian cancer from exceptional long- and short-term survivors by Yang, S Y Cindy, Lheureux, Stephanie, Karakasis, Katherine, Burnier, Julia V, Bruce, Jeffery P, Clouthier, Derek L, Danesh, Arnavaz, Quevedo, Rene, Dowar, Mark, Hanna, Youstina, Li, Tiantian, Lu, Lin, Xu, Wei, Clarke, Blaise A, Ohashi, Pamela S, Shaw, Patricia A, Pugh, Trevor J, Oza, Amit M

“…Patients diagnosed with high-grade serous ovarian cancer (HGSOC) who received initial debulking surgery followed by platinum-based chemotherapy can experience…”
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Activating Mutations Affecting the Dbl Homology Domain of SOS2 Cause Noonan Syndrome by Cordeddu, Viviana, Yin, Jiani C., Gunnarsson, Cecilia, Virtanen, Carl, Drunat, Séverine, Lepri, Francesca, De Luca, Alessandro, Rossi, Cesare, Ciolfi, Andrea, Pugh, Trevor J., Bruselles, Alessandro, Priest, James R., Pennacchio, Len A., Lu, Zhibin, Danesh, Arnavaz, Quevedo, Rene, Hamid, Alaa, Martinelli, Simone, Pantaleoni, Francesca, Gnazzo, Maria, Daniele, Paola, Lissewski, Christina, Bocchinfuso, Gianfranco, Stella, Lorenzo, Odent, Sylvie, Philip, Nicole, Faivre, Laurence, Vlckova, Marketa, Seemanova, Eva, Digilio, Cristina, Zenker, Martin, Zampino, Giuseppe, Verloes, Alain, Dallapiccola, Bruno, Roberts, Amy E., Cavé, Hélène, Gelb, Bruce D., Neel, Benjamin G., Tartaglia, Marco

“…ABSTRACT The RASopathies constitute a family of autosomal‐dominant disorders whose major features include facial dysmorphism, cardiac defects, reduced…”
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Revisiting inconsistency in large pharmacogenomic studies [version 3; peer review: 2 approved, 1 approved with reservations] by Safikhani, Zhaleh, Smirnov, Petr, Freeman, Mark, El-Hachem, Nehme, She, Adrian, Rene, Quevedo, Goldenberg, Anna, Birkbak, Nicolai J, Hatzis, Christos, Shi, Leming, Beck, Andrew H, Aerts, Hugo J.W.L, Quackenbush, John, Haibe-Kains, Benjamin

“…In 2013, we published a comparative analysis of mutation and gene expression profiles and drug sensitivity measurements for 15 drugs characterized in the 471…”
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Centromeric cohesion failure invokes a conserved choreography of chromosomal mis-segregations in pancreatic neuroendocrine tumor by Quevedo, Rene, Spreafico, Anna, Bruce, Jeff, Danesh, Arnavaz, El Ghamrasni, Samah, Giesler, Amanda, Hanna, Youstina, Have, Cherry, Li, Tiantian, Yang, S Y Cindy, Zhang, Tong, Asa, Sylvia L, Haibe-Kains, Benjamin, Krzyzanowska, Monika, Smith, Adam C, Singh, Simron, Siu, Lillian L, Pugh, Trevor J

“…Pancreatic neuroendocrine tumors (PANETs) are rare, slow growing cancers that often present with local and distant metastasis upon detection. PANETS contain…”
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Intracochlear fibrosis and the foreign body response to cochlear implant biomaterials by Foggia, Megan J., Quevedo, Rene Vielman, Hansen, Marlan R.

“…Objective To report current knowledge on the topic of intracochlear fibrosis and the foreign body response following cochlear implantation (CI). Methods A…”
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Author Correction: Gene isoforms as expression-based biomarkers predictive of drug response in vitro by Safikhani, Zhaleh, Smirnov, Petr, Thu, Kelsie L., Silvester, Jennifer, El-Hachem, Nehme, Quevedo, Rene, Lupien, Mathieu, Mak, Tak W., Cescon, David, Haibe-Kains, Benjamin

“…In the original version of this Article, financial support was not fully acknowledged. This error has now been corrected in both the PDF and HTML versions of…”
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A mouse model of cochlear implantation with chronic electric stimulation by Claussen, Alexander D, Vielman Quevedo, René, Mostaert, Brian, Kirk, Jonathon R, Dueck, Wolfram F, Hansen, Marlan R

“…Cochlear implants provide an effective treatment option for those with severe hearing loss, including those with preserved low frequency hearing. However,…”
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Assessment of pharmacogenomic agreement by Safikhani, Zhaleh, El-Hachem, Nehme, Quevedo, Rene, Smirnov, Petr, Goldenberg, Anna, Juul Birkbak, Nicolai, Mason, Christopher, Hatzis, Christos, Shi, Leming, Aerts, Hugo Jwl, Quackenbush, John, Haibe-Kains, Benjamin

“…In 2013 we published an analysis demonstrating that drug response data and gene-drug associations reported in two independent large-scale pharmacogenomic…”
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Chronic cochlear implantation with and without electric stimulation in a mouse model induces robust cochlear influx of CX3CR1+/GFP macrophages by Claussen, Alexander D., Quevedo, René Vielman, Kirk, Jonathon R., Higgins, Timon, Mostaert, Brian, Rahman, Muhammad Taifur, Oleson, Jacob, Hernandez, Reyna, Hirose, Keiko, Hansen, Marlan R.

“…•Cochlear implantation initiates a cochlear innate immune response with accumulation of macrophages•The chronic presence of an indwelling cochlear implant is…”
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The transcription factor IRF2 drives interferon-mediated CD8+ T cell exhaustion to restrict anti-tumor immunity by Lukhele, Sabelo, Rabbo, Diala Abd, Guo, Mengdi, Shen, Jian, Elsaesser, Heidi J., Quevedo, Rene, Carew, Madeleine, Gadalla, Ramy, Snell, Laura M., Mahesh, Lawanya, Ciudad, M. Teresa, Snow, Bryan E., You-Ten, Annick, Haight, Jillian, Wakeham, Andrew, Ohashi, Pamela S., Mak, Tak W., Cui, Weiguo, McGaha, Tracy L., Brooks, David G.

“…Type I and II interferons (IFNs) stimulate pro-inflammatory programs that are critical for immune activation, but also induce immune-suppressive feedback…”
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Modeling the Mechanistic and Therapeutic Roles of Allele Specific Copy Number Alterations in Cancer by Quevedo, Rene

“…Aneuploidy, loosely defined as an imbalance of chromosomes, is found in ~90% of all solid tumors and can affect ~33% of the genome ranging from focal…”
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An Immune Gene Expression Risk Score for Distant Metastases after Radiotherapy for Cervical Cancer by Lukovic, Jelena, Pintilie, Melania, Han, Kathy, Fyles, Anthony W, Bruce, Jeffrey P, Quevedo, Rene, Pugh, Trevor J, Fjeldbo, Christina S, Lyng, Heidi, Milosevic, Michael F

“…To develop an immune-based gene expression risk score to identify patients with cervical cancer at increased risk of distant metastases (DM). Tumor biopsies…”
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The use of a multi-metric readout screen to identify EHMT2/G9a-inhibition as a modulator of cancer-associated fibroblast activation state by Wu, Nila C., Quevedo, Rene, Nurse, Michelle, Hezaveh, Kebria, Liu, Haijiao, Sun, Fumao, Muffat, Julien, Sun, Yu, Simmons, Craig A., McGaha, Tracy L., Prinos, Panagiotis, Arrowsmith, Cheryl H., Ailles, Laurie, D'Arcangelo, Elisa, McGuigan, Alison P.

“…Cancer-associated fibroblasts (CAFs) play a pivotal role in cancer progression, including mediating tumour cell invasion via their pro-invasive secretory…”
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Pre-encoded responsiveness to type I interferon in the peripheral immune system defines outcome of PD1 blockade therapy by Boukhaled, Giselle M., Gadalla, Ramy, Elsaesser, Heidi J., Abd-Rabbo, Diala, Quevedo, Rene, Yang, S. Y. Cindy, Guo, Mengdi, Wang, Ben X., Noamani, Babak, Gray, Diana, Lau, Sally C. M., Taylor, Kirsty, Aung, Kyaw, Spreafico, Anna, Hansen, Aaron R., Saibil, Samuel D., Hirano, Naoto, Guidos, Cynthia, Pugh, Trevor J., McGaha, Tracy L., Ohashi, Pamela S., Sacher, Adrian G., Butler, Marcus O., Brooks, David G.

“…Type I interferons (IFN-Is) are central regulators of anti-tumor immunity and responses to immunotherapy, but they also drive the feedback inhibition…”
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Cochlear implant material effects on inflammatory cell function and foreign body response by Jensen, Megan J., Claussen, Alexander D., Higgins, Timon, Vielman-Quevedo, Rene, Mostaert, Brian, Xu, Linjing, Kirk, Jonathon, Hansen, Marlan R.

“…•Cochlear implant electrodes are comprised of platinum contacts in a PDMS casing.•Components of cochlear implant biomaterials influence the cellular…”
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