Search Results - "Rendleman, Emily J."

Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas by Piunti, Andrea, Hashizume, Rintaro, Morgan, Marc A, Bartom, Elizabeth T, Horbinski, Craig M, Marshall, Stacy A, Rendleman, Emily J, Ma, Quanhong, Takahashi, Yoh-hei, Woodfin, Ashley R, Misharin, Alexander V, Abshiru, Nebiyu A, Lulla, Rishi R, Saratsis, Amanda M, Kelleher, Neil L, James, C David, Shilatifard, Ali

“…Nucleosomes containing mutant K27M histones in diffuse intrinsic pediatric gliomas (DIPG) exclude PRC2 binding and recruit BET bromodomain proteins; however,…”
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Chromatin Hyperacetylation Impacts Chromosome Folding by Forming a Nuclear Subcompartment by Rosencrance, Celeste D., Ammouri, Haneen N., Yu, Qi, Ge, Tiffany, Rendleman, Emily J., Marshall, Stacy A., Eagen, Kyle P.

“…Delineating how chromosomes fold at length scales beyond one megabase remains obscure relative to smaller-scale folding into TADs, loops, and nucleosomes. We…”
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Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation by Douillet, Delphine, Sze, Christie C., Ryan, Caila, Piunti, Andrea, Shah, Avani P., Ugarenko, Michal, Marshall, Stacy A., Rendleman, Emily J., Zha, Didi, Helmin, Kathryn A., Zhao, Zibo, Cao, Kaixiang, Morgan, Marc A., Singer, Benjamin D., Bartom, Elizabeth T., Smith, Edwin R., Shilatifard, Ali

“…The COMPASS protein family catalyzes histone H3 Lys 4 (H3K4) methylation and its members are essential for regulating gene expression. MLL2/COMPASS methylates…”
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Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability by Rickels, Ryan, Herz, Hans-Martin, Sze, Christie C, Cao, Kaixiang, Morgan, Marc A, Collings, Clayton K, Gause, Maria, Takahashi, Yoh-hei, Wang, Lu, Rendleman, Emily J, Marshall, Stacy A, Krueger, Annika, Bartom, Elizabeth T, Piunti, Andrea, Smith, Edwin R, Abshiru, Nebiyu A, Kelleher, Neil L, Dorsett, Dale, Shilatifard, Ali

“…Ali Shilatifard and colleagues generate Drosophila lines expressing catalytically deficient Trr, which normally deposits H3K4me1 at enhancers. Trr mutants…”
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Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced Cancer Therapy by Liang, Kaiwei, Smith, Edwin R., Aoi, Yuki, Stoltz, Kristen L., Katagi, Hiroaki, Woodfin, Ashley R., Rendleman, Emily J., Marshall, Stacy A., Murray, David C., Wang, Lu, Ozark, Patrick A., Mishra, Rama K., Hashizume, Rintaro, Schiltz, Gary E., Shilatifard, Ali

“…The super elongation complex (SEC) is required for robust and productive transcription through release of RNA polymerase II (Pol II) with its P-TEFb module and…”
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Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy by Wang, Lu, Zhao, Zibo, Ozark, Patrick A., Fantini, Damiano, Marshall, Stacy A., Rendleman, Emily J., Cozzolino, Kira A., Louis, Nundia, He, Xingyao, Morgan, Marc A., Takahashi, Yoh-hei, Collings, Clayton K., Smith, Edwin R., Ntziachristos, Panagiotis, Savas, Jeffrey N., Zou, Lihua, Hashizume, Rintaro, Meeks, Joshua J., Shilatifard, Ali

“…The lysine methyltransferase KMT2C (also known as MLL3), a subunit of the COMPASS complex, implements monomethylation of Lys4 on histone H3 (H3K4) at gene…”
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PAF1 regulation of promoter-proximal pause release via enhancer activation by Chen, Fei Xavier, Xie, Peng, Collings, Clayton K., Cao, Kaixiang, Aoi, Yuki, Marshall, Stacy A., Rendleman, Emily J., Ugarenko, Michal, Ozark, Patrick A., Zhang, Anda, Shiekhattar, Ramin, Smith, Edwin R., Zhang, Michael Q., Shilatifard, Ali

“…Gene expression in metazoans is regulated by RNA polymerase II (Pol II) promoter-proximal pausing and its release. Previously,we showed that Pol II–associated…”
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Histone H3K4 methylation-dependent and -independent functions of Set1A/COMPASS in embryonic stem cell self-renewal and differentiation by Sze, Christie C, Cao, Kaixiang, Collings, Clayton K, Marshall, Stacy A, Rendleman, Emily J, Ozark, Patrick A, Chen, Fei Xavier, Morgan, Marc A, Wang, Lu, Shilatifard, Ali

“…Of the six members of the COMPASS (complex of proteins associated with Set1) family of histone H3 Lys4 (H3K4) methyltransferases identified in mammals, Set1A…”
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SET1A/COMPASS and shadow enhancers in the regulation of homeotic gene expression by Cao, Kaixiang, Collings, Clayton K, Marshall, Stacy A, Morgan, Marc A, Rendleman, Emily J, Wang, Lu, Sze, Christie C, Sun, Tianjiao, Bartom, Elizabeth T, Shilatifard, Ali

“…The homeotic (Hox) genes are highly conserved in metazoans, where they are required for various processes in development, and misregulation of their expression…”
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A cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation by Morgan, Marc A J, Rickels, Ryan A, Collings, Clayton K, He, Xiaolin, Cao, Kaixiang, Herz, Hans-Martin, Cozzolino, Kira A, Abshiru, Nebiyu A, Marshall, Stacy A, Rendleman, Emily J, Sze, Christie C, Piunti, Andrea, Kelleher, Neil L, Savas, Jeffrey N, Shilatifard, Ali

“…Histone H3 Lys4 (H3K4) methylation is a chromatin feature enriched at gene -regulatory sequences such as promoters and enhancers. Here we identify an…”
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TET2 coactivates gene expression through demethylation of enhancers by Wang, Lu, Ozark, Patrick A, Smith, Edwin R, Zhao, Zibo, Marshall, Stacy A, Rendleman, Emily J, Piunti, Andrea, Ryan, Caila, Whelan, Anna L, Helmin, Kathryn A, Morgan, Marc Alard, Zou, Lihua, Singer, Benjamin D, Shilatifard, Ali

“…The tet methylcytosine dioxygenase 2 (TET2) enzyme catalyzes the conversion of the modified DNA base 5-methylcytosine to 5-hydroxymethylcytosine. TET2 is…”
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Coordinated regulation of cellular identity-associated H3K4me3 breadth by the COMPASS family by Sze, Christie C, Ozark, Patrick A, Cao, Kaixiang, Ugarenko, Michal, Das, Siddhartha, Wang, Lu, Marshall, Stacy A, Rendleman, Emily J, Ryan, Caila A, Zha, Didi, Douillet, Delphine, Chen, Fei Xavier, Shilatifard, Ali

“…Set1A and Set1B, two members of the COMPASS family of methyltransferases that methylate the histone H3 lysine 4 (H3K4) residue, have been accredited as primary…”
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An Mll4/COMPASS-Lsd1 epigenetic axis governs enhancer function and pluripotency transition in embryonic stem cells by Cao, Kaixiang, Collings, Clayton K, Morgan, Marc A, Marshall, Stacy A, Rendleman, Emily J, Ozark, Patrick A, Smith, Edwin R, Shilatifard, Ali

“…Chromatin regulators control cellular differentiation by orchestrating dynamic developmental gene expression programs, and hence, malfunctions in the…”
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NELF Regulates a Promoter-Proximal Step Distinct from RNA Pol II Pause-Release by Aoi, Yuki, Smith, Edwin R., Shah, Avani P., Rendleman, Emily J., Marshall, Stacy A., Woodfin, Ashley R., Chen, Fei X., Shiekhattar, Ramin, Shilatifard, Ali

“…RNA polymerase II (RNA Pol II) is generally paused at promoter-proximal regions in most metazoans, and based on in vitro studies, this function has been…”
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DOT1L-controlled cell-fate determination and transcription elongation are independent of H3K79 methylation by Cao, Kaixiang, Ugarenko, Michal, Ozark, Patrick A., Wang, Juan, Marshall, Stacy A., Rendleman, Emily J., Liang, Kaiwei, Wang, Lu, Zou, Lihua, Smith, Edwin R., Yue, Feng, Shilatifard, Ali

“…Actively transcribed genes in mammals are decorated by H3K79 methylation, which is correlated with transcription levels and is catalyzed by the histone…”
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SPT5 stabilization of promoter-proximal RNA polymerase II by Aoi, Yuki, Takahashi, Yoh-hei, Shah, Avani P., Iwanaszko, Marta, Rendleman, Emily J., Khan, Nabiha H., Cho, Byoung-Kyu, Goo, Young Ah, Ganesan, Sheetal, Kelleher, Neil L., Shilatifard, Ali

“…Based on in vitro studies, it has been demonstrated that the DSIF complex, composed of SPT4 and SPT5, regulates the elongation stage of transcription catalyzed…”
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Acute perturbation strategies in interrogating RNA polymerase II elongation factor function in gene expression by Zheng, Bin, Aoi, Yuki, Shah, Avani P, Iwanaszko, Marta, Das, Siddhartha, Rendleman, Emily J, Zha, Didi, Khan, Nabiha, Smith, Edwin R, Shilatifard, Ali

“…The regulation of gene expression catalyzed by RNA polymerase II (Pol II) requires a host of accessory factors to ensure cell growth, differentiation, and…”
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A synthetic lethality screen reveals ING5 as a genetic dependency of catalytically dead Set1A/COMPASS in mouse embryonic stem cells by Cenik, Bercin K, Sze, Christie C, Ryan, Caila A, Das, Siddhartha, Cao, Kaixiang, Douillet, Delphine, Rendleman, Emily J, Zha, Didi, Khan, Nabiha Haleema, Bartom, Elizabeth, Shilatifard, Ali

“…Embryonic stem cells (ESCs) are defined by their ability to self-renew and the potential to differentiate into all tissues of the developing organism. We…”
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USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell Leukemia by Jin, Qi, Martinez, Carlos A, Arcipowski, Kelly M, Zhu, Yixing, Gutierrez-Diaz, Blanca T, Wang, Kenneth K, Johnson, Megan R, Volk, Andrew G, Wang, Feng, Wu, Jian, Grove, Charles, Wang, Hui, Sokirniy, Ivan, Thomas, Paul M, Goo, Young Ah, Abshiru, Nebiyu A, Hijiya, Nobuko, Peirs, Sofie, Vandamme, Niels, Berx, Geert, Goosens, Steven, Marshall, Stacy A, Rendleman, Emily J, Takahashi, Yoh-Hei, Wang, Lu, Rawat, Radhika, Bartom, Elizabeth T, Collings, Clayton K, Van Vlierberghe, Pieter, Strikoudis, Alexandros, Kelly, Stephen, Ueberheide, Beatrix, Mantis, Christine, Kandela, Irawati, Bourquin, Jean-Pierre, Bornhauser, Beat, Serafin, Valentina, Bresolin, Silvia, Paganin, Maddalena, Accordi, Benedetta, Basso, Giuseppe, Kelleher, Neil L, Weinstock, Joseph, Kumar, Suresh, Crispino, John D, Shilatifard, Ali, Ntziachristos, Panagiotis

“…T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease, affecting children and adults. Chemotherapy treatments show high response rates but have…”
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BMAL1 drives muscle repair through control of hypoxic NAD + regeneration in satellite cells by Zhu, Pei, Hamlish, Noah X, Thakkar, Abhishek Vijay, Steffeck, Adam W T, Rendleman, Emily J, Khan, Nabiha H, Waldeck, Nathan J, DeVilbiss, Andrew W, Martin-Sandoval, Misty S, Mathews, Thomas P, Chandel, Navdeep S, Peek, Clara B

“…The process of tissue regeneration occurs in a developmentally timed manner, yet the role of circadian timing is not understood. Here, we identify a role for…”
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