Search Results - "Renbin Zhao"

The Demethylase Activity of FTO (Fat Mass and Obesity Associated Protein) Is Required for Preadipocyte Differentiation by Zhang, Meizi, Zhang, Ying, Ma, Jun, Guo, Feima, Cao, Qian, Zhang, Yu, Zhou, Bin, Chai, Jijie, Zhao, Wenqing, Zhao, Renbin

“…FTO (fat mass and obesity associated gene) was genetically identified to be associated with body mass index (BMI), presumably through functional regulation of…”
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A Novel Inhibitor of the Obesity-Related Protein FTO by Qiao, Yan, Zhou, Bin, Zhang, Meizi, Liu, Weijia, Han, Zhifu, Song, Chuanjun, Yu, Wenquan, Yang, Qinghua, Wang, Ruiyong, Wang, Shaomin, Shi, Shuai, Zhao, Renbin, Chai, Jijie, Chang, Junbiao

“…FeII and α-ketoglutarate-dependent fat mass and obesity associated protein (FTO)-dependent demethylation of m6A is important for regulation of mRNA splicing…”
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Identification of A Novel Small-Molecule Binding Site of the Fat Mass and Obesity Associated Protein (FTO) by He, Wu, Zhou, Bin, Liu, Weijia, Zhang, Meizi, Shen, Zhenhua, Han, Zhifu, Jiang, Qingwei, Yang, Qinghua, Song, Chuanjun, Wang, Ruiyong, Niu, Tianhui, Han, Shengna, Zhang, Lirong, Wu, Jie, Guo, Feima, Zhao, Renbin, Yu, Wenquan, Chai, Jijie, Chang, Junbiao

“…N-(5-Chloro-2,4-dihydroxyphenyl)-1-phenylcyclobutanecarboxamide (N-CDPCB, 1a) is found to be an inhibitor of the fat mass and obesity associated protein (FTO)…”
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Cytokines help suggest aplastic anemia with pulmonary bacterial or co-fungal infection by Zhang, Jinping, Yang, Zefeng, Hu, Peng, Guan, Xin, Zhang, Chaoran, Zou, Yunlian, Li, Huiyuan, Yang, Tonghua, Cao, Yue, Zhao, Renbin, Li, Zengzheng

“…Although aplastic anemia (AA) does not come under the category of blood malignant diseases, the infection that frequently occurs in this bone marrow failure…”
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Cytokine Expression of Lung Bacterial Infection in Newly Diagnosed Adult Hematological Malignancies by Li, Zengzheng, Yang, Zefeng, Hu, Peng, Guan, Xin, Zhang, Lihua, Zhang, Jinping, Yang, Tonghua, Zhang, Chaoran, Zhao, Renbin

“…Adult patients with hematological malignancies are frequently accompanied by bacterial infections in the lungs when they are first diagnosed. Sputum culture,…”
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Increased Cytokine Levels Assist in the Diagnosis of Respiratory Bacterial Infections or Concurrent Bacteremia in Patients With Non-Hodgkin's Lymphoma by Zhang, Lihua, Zhang, Jinping, He, Haiping, Ling, Xiaosui, Li, Fan, Yang, Zefeng, Zhao, Jinlian, Li, Huiyuan, Yang, Tonghua, Zhao, Shixiang, Shi, Keqian, Guan, Xin, Zhao, Renbin, Li, Zengzheng

“…Non-Hodgkin's lymphoma (NHL) is a form of tumor that originates in the lymphoid tissues. Bacterial infections are very common in NHL patients. Because most of…”
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Traditional Chinese medicine compound, Bu Sheng Hui Yang Fang, promotes the proliferation of lymphocytes in the immunosuppressed mice potentially by upregulating IL-4 signaling by Wang, Yajie, Tan, Jiabin, Hu, Peng, Pei, Qiang, Wen, Yan, Ma, Wenqing, Shi, Keqian, Li, Zengzheng, Li, Huiyuan, Cheng, Fengyu, Gu, Xuezhong, Yao, Xiangmei, Man, Yan, Zhao, Renbin, Feng, Shuai, Ding, Xiao, Yang, Tonghua

“…[Display omitted] •BSHY upregulates the numbers of lymphocytes in immunosuppressed mice.•BSHY increases proliferation and decreases apoptosis of…”
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Analysis of p53-regulated gene expression patterns using oligonucleotide arrays by Zhao, R, Gish, K, Murphy, M, Yin, Y, Notterman, D, Hoffman, W H, Tom, E, Mack, D H, Levine, A J

“…Oligonucleotide microarrays were employed to quantitate mRNA levels from a large number of genes regulated by the p53 transcription factor. Responses to DNA…”
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SNPstream® UHT: Ultra-High Throughput SNP Genotyping for Pharmacogenomics and Drug Discovery by Peter A. Bell, Surendra Chaturvedi, Craig A. Gelfand, Ching Yu Huang, Michael Kochersperger, Rafael Kopla, Frank Modica, Mark Pohl, Shobha Varde, Renbin Zhao, Xiaojian Zhao, Michael T. Boyce-Jacino

“…Single nucleotide polymorphism (SNP) genotyping is playing an increasing role in genome mapping, pharmacogenetic studies, and drug discovery. To date,…”
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Extracts from Glycine max (soybean) induce elastin synthesis and inhibit elastase activity by Zhao, Renbin, Bruning, Elizabeth, Rossetti, Dianne, Starcher, Barry, Seiberg, Miri, Iotsova‐Stone, Violetta

“…:  Elastic fibres are essential extracellular matrix components of the skin, contributing to its resilience and elasticity. In the course of skin ageing,…”
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Characterization of GDF-10 Expression Patterns and Null Mice by Zhao, Renbin, Lawler, Ann M., Lee, Se-Jin

“…Growth/differentiation factor-10 (GDF-10) is a TGF-β family member highly related to bone morphogenetic protein-3. In order to determine the biological…”
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A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study Evaluating the Efficacy and Safety of Orelabrutinib Plus R-CHOP Versus Placebo Plus R-CHOP in Treatment-Naïve Patients with Mcd Subtype Diffuse Large B-Cell Lymphoma by Xu, Pengpeng, Fan, Ni, Tian, Yamin, Tang, Xinran, Zhang, Bin, Zhou, Wei, Zhao, Renbin, Zhao, Weili

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Phase I result of ICP-192 (gunagratinib), a highly selective irreversible FGFR inhibitor, in patients with advanced solid tumors harboring FGFR pathway alterations by Guo, Ye, Yuan, Chunwang, Ying, Jieer, Zhu, Xu, Luan, Guodong, Zhang, Bin, Zhao, Renbin, Li, Jin

“…Abstract only 4092 Background: ICP-192 (gunagratinib), developed by InnoCare Pharma, is a novel pan-FGFR (fibroblast growth factor receptors) inhibitor that…”
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Changes in expression levels of immune cells and inflammatory cytokines in pre-eclampsia patients before and after delivery by Shen, Cuihua, Song, Ying, Fan, Wei, Guo, Xiaojuan, Li, Jia, Zhao, Renbin

“…By analyze the expression levels of immune cells and cytokines secreted by preeclampsia patients before and after delivery. Furthermore, to determine the…”
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Phase I results of gunagratinib (ICP-192), a highly selective irreversible FGFR 1-4 inhibitor in patients with head and neck cancer harboring FGF/FGFR gene aberrations by Guo, Ye, Li, Qun, Tang, Wenbo, Lin, Fengjuan, Xue, Junli, Xue, Liqiong, Ge, Xiaoxiao, Zhao, Wei, Zhou, Wei, Zhao, Renbin, Zhang, Bin, Li, Jin

“…6039 Background: The fibroblast growth factor (FGF) and FGF receptor (FGFR) signaling pathway has been evaluated as critical driver of carcinogenesis in…”
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Safety, pharmacokinetics (PK), and clinical efficacy of ICP-723, a highly selective next-generation pan-TRK inhibitor, in patients with solid tumor by Wei, Xiao-Li, Wang, Fenghua, Zhang, Xiaochen, Xu, Nong, Gao, Jie, Pu, Xuan, Qin, Zhoushuai, Guo, Miao, Zhang, Bin, Zhao, Renbin, Zhang, Sean Sean, Xu, Rui-hua

“…3106 Background: NTRK gene fusion resulting from NTRK1/2/3 genetic alterations occurs in various adult and pediatric cancers, which is one of the most defined…”
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Orelabrutinib Monotherapy in Patients with Relapsed or Refractory Waldenström's Macroglobulinemia in a Single-Arm, Multicenter, Open-Label, Phase 2 Study: Long Term Follow-up Results by Cao, Xinxin, Jin, Jie, Cheng Cheng, Fu, Yi, Shuhua, Zhao, Weili, Sun, Zimin, Yang, Wei, Li, Dengju, CUI, Guohui, Hu, Jianda, Liu, Ting, Song, Yongping, Xu, Bing, Zhu, Zunmin, Xu, Wei, Zhang, Mingzhi, Li, Sichen, Wang, Weige, Zhao, Renbin, Zhou, Daobin

“…Background Orelabrutinib is a novel, small molecule, selective irreversible Bruton tyrosine kinase inhibitor, approved in China for the treatment of patients…”
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Abstract CT132: Orelabrutinib, a potent and selective Bruton's tyrosine kinase inhibitor with superior safety profile and excellent PK/PD properties by Zhang, Bin, Zhao, Renbin, Liang, Ruixia, Gao, Yingxiang, Liu, Richard, Chen, Xiangyang, Lu, Zhengguang, Wang, Zuopeng, Yu, Liqin, Shakib, Sepehr, Cui, Jisong

“…Abstract Bruton's tyrosine kinase (BTK) as a therapeutic target for B-cell malignancies, including mantle cell lymphoma (MCL), chronic lymphocytic…”
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Clinical Observation on 98 Cases of Hematological Malignancies Treated with Autologous Hematopoietic Stem Cell Transplantation Cryopreserved By Ladder-Style Freezing from Low Temperature Refrigerator to Liquid Nitrogen by Peng, Hu, Yang, Tonghua, Zhao, Renbin, Shi, Keqian, Lai, Xun, Yang, Yanmei

“…Background: Programmed cooling - 196℃ liquid nitrogen preservation and non- programmed cooling - 80℃ low temperature refrigerator preservation have been widely…”
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Analysis of cytokine risk factors in the early death of patients with secondary phagocytic lymphocytic histiocytosis by Li, Zengzheng, Liu, Jianqiong, Man, Yan, Liu, Fusheng, Gao, Lili, Hu, Peng, Zhao, Renbin, Wang, Yajie, Yang, Tonghua

“…Secondary hemophagocytic lymphohistiocytosis (sHLH) is an excessive inflammatory response syndrome caused by immune abnormalities. Up to date, the risk factors…”
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