Search Results - "Renaux, Bernard"

Thrombin-Mediated Direct Activation of Proteinase-Activated Receptor-2: Another Target for Thrombin Signaling by Mihara, Koichiro, Ramachandran, Rithwik, Saifeddine, Mahmoud, Hansen, Kristina K, Renaux, Bernard, Polley, Danny, Gibson, Stacy, Vanderboor, Christina, Hollenberg, Morley D

“…Thrombin is known to signal to cells by cleaving/activating a G-protein-coupled family of proteinase-activated receptors (PARs). The signaling mechanism…”
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Anti-Inflammatory Benefits of Antibiotics: Tylvalosin Induces Apoptosis of Porcine Neutrophils and Macrophages, Promotes Efferocytosis, and Inhibits Pro-Inflammatory CXCL-8, IL1α, and LTB4 Production, While Inducing the Release of Pro-Resolving Lipoxin A4 and Resolvin D1 by Moges, Ruth, De Lamache, Dimitri Desmonts, Sajedy, Saman, Renaux, Bernard S., Hollenberg, Morley D., Muench, Gregory, Abbott, Elizabeth M., Buret, Andre G.

“…Excessive accumulation of neutrophils and their uncontrolled death by necrosis at the site of inflammation exacerbates inflammatory responses and leads to…”
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Tulathromycin Exerts Proresolving Effects in Bovine Neutrophils by Inhibiting Phospholipases and Altering Leukotriene B4, Prostaglandin E2, and Lipoxin A4 Production by FISCHER, Carrie D, DUQUETTE, Stephanie C, RENAUX, Bernard S, FEENER, Troy D, MORCK, Douglas W, HOLLENBERG, Morley D, LUCAS, Merlyn J, BURET, Andre G

“…The accumulation of neutrophils and proinflammatory mediators, such as leukotriene B4 (LTB4), is a classic marker of inflammatory disease. The clearance of…”
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Epidermal growth factor receptor transactivation is required for proteinase-activated receptor-2-induced COX-2 expression in intestinal epithelial cells by Hirota, Christina L, Moreau, France, Iablokov, Vadim, Dicay, Michael, Renaux, Bernard, Hollenberg, Morley D, MacNaughton, Wallace K

“…Proteinase-activated receptor (PAR)(2), a G protein-coupled receptor activated by serine proteinases, has been implicated in both intestinal inflammation and…”
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Thrombin Cleavage of Plasmodium falciparum Erythrocyte Membrane Protein 1 Inhibits Cytoadherence by Gillrie, Mark R, Renaux, Bernard, Russell-Goldman, Eleanor, Avril, Marion, Brazier, Andrew J, Mihara, Koichiro, Di Cera, Enrico, Milner, Jr, Danny A, Hollenberg, Morley D, Smith, Joseph D, Ho, May

“…Plasmodium falciparum malaria remains one of the most deadly infections worldwide. The pathogenesis of the infection results from the sequestration of infected…”
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Derivatized 2-furoyl-LIGRLO-amide, a versatile and selective probe for proteinase-activated receptor 2: binding and visualization by Hollenberg, Morley D, Renaux, Bernard, Hyun, Eric, Houle, Steeve, Vergnolle, Nathalie, Saifeddine, Mahmoud, Ramachandran, Rithwik

“…The proteinase-activated receptor-2 (PAR2)-activating peptide with an N-terminal furoyl group modification, 2-furoyl-LIGRLO-NH2 (2fLI), was derivatized via its…”
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Implantation serine proteinase 1 exhibits mixed substrate specificity that silences signaling via proteinase-activated receptors by Sharma, Navneet, Kumar, Rajeev, Renaux, Bernard, Saifeddine, Mahmoud, Nishikawa, Sandra, Mihara, Koichiro, Ramachandran, Rithwik, Hollenberg, Morley D, Rancourt, Derrick E

“…Implantation S1 family serine proteinases (ISPs) are tryptases involved in embryo hatching and uterine implantation in the mouse. The two different ISP…”
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Glycosylation and the activation of proteinase‐activated receptor 2 (PAR2) by human mast cell tryptase by Compton, Steven J, Renaux, Bernard, Wijesuriya, Suranga J, Hollenberg, Morley D

“…Human mast cell tryptase appears to display considerable variation in activating proteinase‐activated receptor 2 (PAR2). We found tryptase to be an inefficient…”
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Neutrophil Elastase and Proteinase-3 Trigger G Protein-biased Signaling through Proteinase-activated Receptor-1 (PAR1) by Mihara, Koichiro, Ramachandran, Rithwik, Renaux, Bernard, Saifeddine, Mahmoud, Hollenberg, Morley D.

“…Neutrophil proteinases released at sites of inflammation can affect tissue function by either activating or disarming signal transduction mediated by…”
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Neutrophil Elastase Acts as a Biased Agonist for Proteinase-activated Receptor-2 (PAR2) by Ramachandran, Rithwik, Mihara, Koichiro, Chung, Hyunjae, Renaux, Bernard, Lau, Chang S., Muruve, Daniel A., DeFea, Kathryn A., Bouvier, Michel, Hollenberg, Morley D.

“…Human neutrophil proteinases (elastase, proteinase-3, and cathepsin-G) are released at sites of acute inflammation. We hypothesized that these…”
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NADPH oxidase modifies patterns of MHC class II-restricted epitopic repertoires through redox control of antigen processing by Allan, Euan R O, Tailor, Pankaj, Balce, Dale R, Pirzadeh, Payman, McKenna, Neil T, Renaux, Bernard, Warren, Amy L, Jirik, Frank R, Yates, Robin M

“…The chemistries within phagosomes of APCs mediate microbial destruction as well as generate peptides for presentation on MHC class II. The antimicrobial…”
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Interferon gamma decreases intestinal epithelial aquaporin 3 expression through downregulation of constitutive transcription by Peplowski, Michael A., Dicay, Michael, Baggio, Cristiane H., Wysokinski, Filip, Renaux, Bernard, Hollenberg, Morley D., Proud, David, MacNaughton, Wallace K.

“…Aquaporin (AQP) 3 expression is altered in inflammatory bowel diseases, although the exact mechanisms regulating AQP abundance are unclear. Although interferon…”
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Cockroach allergen serine proteinases: Isolation, sequencing and signalling via proteinase‐activated receptor‐2 by Polley, D. J., Mihara, K., Ramachandran, R., Vliagoftis, H., Renaux, B., Saifeddine, M., Daines, M. O., Boitano, S., Hollenberg, M. D.

“…Summary Background Allergy to the German cockroach (Blattella germanica) is a significant asthma risk factor for inner‐city communities. Cockroach, like other…”
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Proteinase-activated receptors (PARs): differential signalling by kallikrein-related peptidases KLK8 and KLK14 by Ramachandran, Rithwik, Eissa, Azza, Mihara, Koichiro, Oikonomopoulou, Katerina, Saifeddine, Mahmoud, Renaux, Bernard, Diamandis, Eleftherios, Hollenberg, Morley D

“…We compared signalling pathways such as calcium transients, MAPK activation, β-arrestin interactions and receptor internalization triggered by…”
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Purification and characterization of mouse protamines, P1 and P2. Amino-acid sequence of P2 by Bellve, Anthony R, McKay, Donald J, Renaux, Bernard S, Dixon, Gordon H

“…Two mouse protamines, denoted as P1 and P2, have been purified directly from mature sperm nuclei and characterized as distinct polypeptide species. The…”
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Tulathromycin Exerts Proresolving Effects in Bovine Neutrophils by Inhibiting Phospholipases and Altering Leukotriene B 4 , Prostaglandin E 2 , and Lipoxin A 4 Production by Fischer, Carrie D., Duquette, Stephanie C., Renaux, Bernard S., Feener, Troy D., Morck, Douglas W., Hollenberg, Morley D., Lucas, Merlyn J., Buret, Andre G.

“…ABSTRACT The accumulation of neutrophils and proinflammatory mediators, such as leukotriene B 4 (LTB 4 ), is a classic marker of inflammatory disease. The…”
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Tumor necrosis factor α decreases aquaporin 3 expression in intestinal epithelial cells through inhibition of constitutive transcription by Peplowski, Michael A., Vegso, Andrew J., Iablokov, Vadim, Dicay, Michael, Zaheer, Raza S., Renaux, Bernard, Proud, David, Hollenberg, Morley D., Beck, Paul L., MacNaughton, Wallace K.

“…Inflammatory diseases of the gut are associated with altered electrolyte and water transport, leading to the development of diarrhea. Epithelially expressed…”
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High spatial resolution mapping of surface velocities and depths for shallow overland flow by Legout, C., Darboux, F., Nédélec, Y., Hauet, A., Esteves, M., Renaux, B., Denis, H., Cordier, S.

“…ABSTRACT Point measurements of flow rate, depth or velocity are not sufficient to validate overland flow models, particularly when the interaction of the water…”
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Allergen‐derived proteinases: Isolation, characterization and signaling via proteinase‐activated receptors (PARs) by Polley, Danny, Mihara, Koichiro, Saifeddine, Mahmoud, Renaux, Bernard, Vliagoftis, Harrisios, Boitano, Scott, Daines, Michael, Hollenberg, Morley D.

“…Abstract only Objective To identify proteolytic enzymes in insect and mould asthma allergens and assess their ability to signal via the PARs. Methods…”
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Implantation serine proteinase 2 is a monomeric enzyme with mixed serine proteolytic activity and can silence signalling via proteinase activated receptors by Sharma, Navneet, Fahr, Jochen, Renaux, Bernard, Saifeddine, Mahmoud, Kumar, Rajeev, Nishikawa, Sandra, Mihara, Koichiro, Ramachandran, Rithwik, Hollenberg, Morley D, Rancourt, Derrick E

“…Implantation serine proteinase 2 (ISP2), a S1 family serine proteinase, is known for its role in the critical processes of embryo hatching and implantation in…”
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