167b Apoptosis, intrinsic radiosensitivity and prediction of radiotherapy response in cervical carcinoma

Apoptosis has been thought a feature of radioresponsive malignancy. Sixty-six patients with cervical cancer & previously measured intrinsic radiosensitivity following 2 Gy of radiation (SF2 value) had measurement of the percentage of apoptotic cells (Apoptotic Index or AI). AI was recorded in te...

Full description

Saved in:

Bibliographic Details
Published in:	European journal of cancer (1990) Vol. 31; p. S38
Main Authors:	Levine, E.L., Renahan, A., Gossiel, R., Davidson, S.E., Roberts, S.A., Chadwick, C., Wilks, D.P., Potten, C.S., Hendry, J.H., Hunter, R.D., West, C.M.L.
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 01-11-1995
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Apoptosis has been thought a feature of radioresponsive malignancy. Sixty-six patients with cervical cancer & previously measured intrinsic radiosensitivity following 2 Gy of radiation (SF2 value) had measurement of the percentage of apoptotic cells (Apoptotic Index or AI). AI was recorded in ten H and E stained tumour sections with Mitotic Index (MI) and KI–67 positivity as measures of proliferation. High AI was associated with poor prognosis. Five-year survival & local control for tumours with an AI below the median was greater than for those with an AI above the median (79% versus 47% for survival, P = 0.003; 79% versus 61% for local control, P = 0.01). AI & SF2 were independent, but AI correlated with MI & KI–67. Patients with both an SF2 & AI value above the median did badly (25% 5-year survival, 46% local control) compared with those with values below the median (80% 5-year survival, 100% local control), AI may reflect proliferation and could be used with SF2 as a predictor of tumour response to radiotherapy.
ISSN:	0959-8049 1879-0852
DOI:	10.1016/0959-8049(95)95424-5