Search Results - "René Lutter"

Cadherin-related family member 3 (CDHR3) drives differentiation of ciliated bronchial epithelial cells and facilitates rhinovirus C infection, although with a little help by Lutter, René, Ravanetti, Lara

“…Cadherin-related family member 3 (CDHR3) was identified earlier as a susceptibility locus for recurrent severe exacerbations in patients with early childhood…”
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Neutrophil extracellular traps cause airway obstruction during respiratory syncytial virus disease by Cortjens, Bart, de Boer, Onno J, de Jong, Rineke, Antonis, Adriaan FG, Sabogal Piñeros, Yanaika S, Lutter, René, van Woensel, Job BM, Bem, Reinout A

“…Human respiratory syncytial virus (RSV) is the most important cause of severe lower respiratory tract disease (LRTD) in young children worldwide. Extensive…”
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Oxidative stress and macrophages: driving forces behind exacerbations of asthma and chronic obstructive pulmonary disease? by de Groot, Linsey E S, van der Veen, T Anienke, Martinez, Fernando O, Hamann, Jörg, Lutter, René, Melgert, Barbro N

“…Oxidative stress is a common feature of obstructive airway diseases like asthma and chronic obstructive pulmonary disease (COPD). Lung macrophages are key…”
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Efficacy of FP‐025: A novel matrix metalloproteinase‐12 (MMP‐12) inhibitor in murine allergic asthma by Ravanetti, Lara, Dekker, Tamara, Guo, Lihui, Dijkhuis, Annemiek, Dierdorp, Barbara S., Diamant, Zuzana, Florquin, Sandrine, Lutter, René

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Intravenous Infusion of Human Adipose Mesenchymal Stem Cells Modifies the Host Response to Lipopolysaccharide in Humans: A Randomized, Single‐Blind, Parallel Group, Placebo Controlled Trial by Perlee, Desiree, van Vught, Lonneke A., Scicluna, Brendon P., Maag, Anja, Lutter, René, Kemper, Elles M., van ‘t Veer, Cornelis, Punchard, Marie A., González, Jesús, Richard, Marie Paule, Dalemans, Wilfried, Lombardo, Eleuterio, de Vos, Alex F., van der Poll, Tom

“…In experimental models, mesenchymal stem cells (MSCs) can modulate various immune responses implicated in the pathogenesis of sepsis. Intravenous injection of…”
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Reply: Key role of dysregulated airway epithelium in response to respiratory viral infections in asthma by Lutter, René, Ravi, Abilash

“…We thank F. Moheimani and colleagues for their interest in our paper and their considerations, to which we like to respond. The defective translational control…”
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Acute respiratory distress syndrome leads to reduced ratio of ACE/ACE2 activities and is prevented by angiotensin-(1-7) or an angiotensin II receptor antagonist by Wösten-van Asperen, Roelie M, Lutter, René, Specht, Patricia A, Moll, Gert N, van Woensel, Job B, van der Loos, Chris M, van Goor, Harry, Kamilic, Jelena, Florquin, Sandrine, Bos, Albert P

“…Acute respiratory distress syndrome (ARDS) is a devastating clinical syndrome. Angiotensin‐converting enzyme (ACE) and its effector peptide angiotensin (Ang)…”
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Anti-IL-5 in Mild Asthma Alters Rhinovirus-induced Macrophage, B-Cell, and Neutrophil Responses (MATERIAL). A Placebo-controlled, Double-Blind Study by Sabogal Piñeros, Yanaika S, Bal, Suzanne M, van de Pol, Marianne A, Dierdorp, Barbara S, Dekker, Tamara, Dijkhuis, Annemiek, Brinkman, Paul, van der Sluijs, Koen F, Zwinderman, Aeilko H, Majoor, Christof J, Bonta, Peter I, Ravanetti, Lara, Sterk, Peter J, Lutter, René

“…Eosinophils drive pathophysiology in stable and exacerbating eosinophilic asthma, and therefore treatment is focused on the reduction of eosinophil numbers…”
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The impact of daily supplementation with rhamnogalacturonan-I on the gut microbiota in healthy adults: A randomized controlled trial by Jian, Ching, Sorensen, Nikolaj, Lutter, René, Albers, Ruud, de Vos, Willem, Salonen, Anne, Mercenier, Annick

“…Pectin and its derivatives have been shown to modulate immune signaling as well as gut microbiota in preclinical studies, which may constitute the mechanisms…”
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A randomised controlled trial on the effect of inhaled hypertonic saline on quality of life in primary ciliary dyskinesia by Paff, Tamara, Daniels, Johannes M A, Weersink, Els J, Lutter, René, Vonk Noordegraaf, Anton, Haarman, Eric G

“…Hypertonic saline inhalation lowers airway mucous viscosity. Increased cough transportability may improve quality of life (QoL) in primary ciliary dyskinesia…”
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IL-33 drives influenza-induced asthma exacerbations by halting innate and adaptive antiviral immunity by Ravanetti, Lara, Dijkhuis, Annemiek, Dekker, Tamara, Sabogal Pineros, Yanaika S., Ravi, Abilash, Dierdorp, Barbara S., Erjefält, Jonas S., Mori, Michiko, Pavlidis, Stelios, Adcock, Ian M., Rao, Navin L., Lutter, René

“…Influenza virus triggers severe asthma exacerbations for which no adequate treatment is available. It is known that IL-33 levels correlate with exacerbation…”
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Eosinophils capture viruses, a capacity that is defective in asthma by Sabogal Piñeros, Yanaika S., Bal, Suzanne M., Dijkhuis, Annemiek, Majoor, Christof J., Dierdorp, Barbara S., Dekker, Tamara, Hoefsmit, Esmée P., Bonta, Peter I., Picavet, Daisy, van der Wel, Nicole N., Koenderman, Leo, Sterk, Peter J., Ravanetti, Lara, Lutter, René

“…Background Activated eosinophils cause major pathology in stable and exacerbating asthma; however, they can also display protective properties like an…”
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Immune suppression is associated with enhanced systemic inflammatory, endothelial and procoagulant responses in critically ill patients by Brands, Xanthe, Uhel, Fabrice, van Vught, Lonneke A, Wiewel, Maryse A, Hoogendijk, Arie J, Lutter, René, Schultz, Marcus J, Scicluna, Brendon P, van der Poll, Tom

“…Objective Patients admitted to the Intensive Care Unit (ICU) oftentimes show immunological signs of immune suppression. Consequently, immune stimulatory agents…”
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Loss of adaptive capacity in asthmatic patients revealed by biomarker fluctuation dynamics after rhinovirus challenge by Sinha, Anirban, Lutter, René, Xu, Binbin, Dekker, Tamara, Dierdorp, Barbara, Sterk, Peter J, Frey, Urs, Eckert, Edgar Delgado

“…Asthma is a dynamic disease, in which lung mechanical and inflammatory processes interact in a complex manner, often resulting in exaggerated physiological, in…”
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The plasma kynurenine-to-tryptophan ratio as a biomarker of tuberculosis disease in people living with HIV on antiretroviral therapy: an exploratory nested case-control study by Gatechompol, Sivaporn, Lutter, René, Vaz, Frédéric M, Ubolyam, Sasiwimol, Avihingsanon, Anchalee, Kerr, Stephen J, van Leth, Frank, Cobelens, Frank

“…Non-sputum-based tests are needed to predict or diagnose tuberculosis (TB) disease in people living with HIV (PWH). The enzyme indoleamine 2, 3-dioxygenase-1…”
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Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency by Kezic, Sanja, PhD, O’Regan, Gráinne M., MRCPI, Lutter, René, PhD, Jakasa, Ivone, PhD, Koster, Ellen S., PhD, Saunders, Sean, BSc, Caspers, Peter, PhD, Kemperman, Patrick M.J.H., MD, Puppels, Gerwin J., PhD, Sandilands, Aileen, PhD, Chen, Huijia, PhD, Campbell, Linda E., BSc, Kroboth, Karin, MSc, Watson, Rosemarie, MD, Fallon, Padraic G., PhD, McLean, W. H. Irwin, DSc, FMedSci, Irvine, Alan D., MD, FRCPI

“…Background Filaggrin (FLG) mutations result in reduced stratum corneum (SC) natural moisturizing factor (NMF) components and consequent increased SC pH…”
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Neutrophilic inflammation in asthma and defective epithelial translational control by Ravi, Abilash, Chowdhury, Saheli, Dijkhuis, Annemiek, Bonta, Peter I, Sterk, Peter J, Lutter, René

“…Neutrophilic inflammation in asthma is associated with interleukin (IL)-17A, corticosteroid-insensitivity and bronchodilator-induced forced expiratory volume…”
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Pulmonary Procoagulant and Innate Immune Responses in Critically Ill COVID-19 Patients by Nossent, Esther J., Schuurman, Alex R., Reijnders, Tom D.Y., Saris, Anno, Jongerius, Ilse, Blok, Siebe G., de Vries, Heder, Duitman, JanWillem, Vonk Noordegraaf, Anton, Meijboom, Lilian J., Lutter, René, Heunks, Leo, Bogaard, Harm Jan, van der Poll, Tom

“…Rationale Systemic activation of procoagulant and inflammatory mechanisms has been implicated in the pathogenesis of COVID-19. Knowledge of activation of these…”
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Tissue-specific expression of IgG receptors by human macrophages ex vivo by Bruggeman, Christine W, Houtzager, Julia, Dierdorp, Barbara, Kers, Jesper, Pals, Steven T, Lutter, René, van Gulik, Thomas, den Haan, Joke M M, van den Berg, Timo K, van Bruggen, Robin, Kuijpers, Taco W

“…Recently it was discovered that tissue-resident macrophages derive from embryonic precursors, not only from peripheral blood monocytes, and maintain themselves…”
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Acute cigarette smoke exposure leads to higher viral infection in human bronchial epithelial cultures by altering interferon, glycolysis and GDF15-related pathways by Wang, Ying, Ninaber, Dennis K, Faiz, Alen, van der Linden, Abraham C, van Schadewijk, Annemarie, Lutter, René, Hiemstra, Pieter S, van der Does, Anne M, Ravi, Abilash

“…Abstract Background Acute exacerbations of chronic inflammatory lung diseases, such as chronic obstructive pulmonary disease (COPD), are frequently associated…”
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