Search Results - "Ren, Zhenning"
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Structure and mechanism of human diacylglycerol O-acyltransferase 1
Published in Nature (London) (01-05-2020)“…Diacylglycerol O -acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans 1 . DGAT1…”
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Structural basis of ion transport and inhibition in ferroportin
Published in Nature communications (10-11-2020)“…Ferroportin is an iron exporter essential for releasing cellular iron into circulation. Ferroportin is inhibited by a peptide hormone, hepcidin. In humans,…”
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Mechanism of ligand activation of a eukaryotic cyclic nucleotide−gated channel
Published in Nature structural & molecular biology (01-07-2020)“…Cyclic nucleotide–gated (CNG) channels convert cyclic nucleotide (CN) binding and unbinding into electrical signals in sensory receptors and neurons. The…”
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Structural basis for inhibition and regulation of a chitin synthase from Candida albicans
Published in Nature structural & molecular biology (01-07-2022)“…Chitin is an essential component of the fungal cell wall. Chitin synthases (Chss) catalyze chitin formation and translocation across the membrane and are…”
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Structural basis for inhibition and regulation of a chitin synthase from Candida albicans
Published in Biophysical journal (10-02-2023)Get full text
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Structure and Dynamics of the EIIC Sugar Uptake System
Published in Biophysical journal (27-01-2015)Get full text
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Extracellular domain of PepT1 interacts with TM1 to facilitate substrate transport
Published in Structure (London) (07-07-2022)“…Mammalian peptide transporters, PepT1 and PepT2, mediate uptake of small peptides and are essential for their absorption. PepT also mediates absorption of many…”
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Insight into the mechanism of H + -coupled nucleobase transport
Published in Proceedings of the National Academy of Sciences - PNAS (15-08-2023)“…Members of the nucleobase/ascorbic acid transporter (NAT) gene family are found in all kingdoms of life. In mammals, the concentrative uptake of ascorbic acid…”
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Molecular Simulation and Biochemical Studies Support an Elevator-type Transport Mechanism in EIIC
Published in Biophysical journal (06-06-2017)“…Enzyme IIC (EIIC) is a membrane-embedded sugar transport protein that is part of the phosphoenolpyruvate-dependent phosphotransferases. Crystal structures of…”
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Structural Basis of Ion Transport and Inhibition in Ferroportin
Published in Biophysical journal (12-02-2021)Get full text
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The Ion-Transporter NKCC1 as a Target for Brain Diseases
Published in Biophysical journal (07-02-2020)Get full text
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Molecular Dynamics Studies Support Elevator Type Transport Mechanisms in the Glucose EIIC Superfamily Transporters
Published in Biophysical journal (03-02-2017)Get full text
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The Structure of a Sugar Transporter of the Glucose EIIC Superfamily Provides Insight into the Elevator Mechanism of Membrane Transport
Published in Structure (London) (07-06-2016)“…The phosphoenolpyruvate:carbohydrate phosphotransferase systems are found in bacteria, where they play central roles in sugar uptake and regulation of cellular…”
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Structure and Catalytic Mechanism of Human Diacylglycerol O-Acyltransferase 1
Published in Biophysical journal (07-02-2020)Get full text
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Structure of an EIIC sugar transporter trapped in an inward-facing conformation
Published in Proceedings of the National Academy of Sciences - PNAS (05-06-2018)“…The phosphoenolpyruvate-dependent phosphotransferase system (PTS) transports sugar into bacteria and phosphorylates the sugar for metabolic consumption. The…”
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Elevator-Like Mechanism of Transport in the EIIC Glucose Superfamily of Transporters
Published in Biophysical journal (03-02-2017)Get full text
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Crystal Structure of an EIIC Trapped in an Inward-Facing Conformation
Published in Biophysical journal (02-02-2018)Get full text
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Controllable Molecule Transport and Release by a Restorable Surface-tethered DNA nanodevice
Published in Scientific reports (07-07-2016)“…In this paper, we report a novel surface-tethered DNA nanodevice that may present three states and undergo conformational changes under the operation of pH…”
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Structure and Function of a Sodium and Proton Coupled Nucleobase/Ascorbate Transporter
Published in Biophysical journal (16-02-2016)Get full text
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Transport Mechanism of the EIIC Glucose Superfamily of Transporters
Published in Biophysical journal (16-02-2016)Get full text
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