Search Results - "Ren, Zhenhua"

A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8+ T-cell response and effective tumor control by Sun, Zhichen, Ren, Zhenhua, Yang, Kaiting, Liu, Zhida, Cao, Shuaishuai, Deng, Sisi, Xu, Lily, Liang, Yong, Guo, Jingya, Bian, Yingjie, Xu, Hairong, Shi, Jiyun, Wang, Fan, Fu, Yang-Xin, Peng, Hua

“…While IL-2 can potently activate both NK and T cells, its short in vivo half-life, severe toxicity, and propensity to amplify Treg cells are major barriers…”
Get full text

Selective delivery of low-affinity IL-2 to PD-1+ T cells rejuvenates antitumor immunity with reduced toxicity by Ren, Zhenhua, Zhang, Anli, Sun, Zhichen, Liang, Yong, Ye, Jianfeng, Qiao, Jian, Li, Bo, Fu, Yang-Xin

“…PD-1 signaling on T cells is the major pathway that limits T cell immunity, but the efficacy of anti-PD-1 therapy has been limited to a small proportion of…”
Get full text

Effect of Nanographite Conductive Concrete Mixed with Magnetite Sand Excited by Different Alkali Activators and Their Combinations on the Properties of Conductive Concrete by Ren, Zhenhua, Zeng, Hao, Zeng, Xiantao, Chen, Xi, Wang, Xiangyu

“…In order to obtain conductive concrete with good electrical conductivity and good mechanical properties, nanographite and magnetite sand excited by different…”
Get full text

Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling by Han, Chuanhui, Liu, Zhida, Zhang, Yunjia, Shen, Aijun, Dong, Chunbo, Zhang, Anli, Moore, Casey, Ren, Zhenhua, Lu, Changzheng, Cao, Xuezhi, Zhang, Chun-Li, Qiao, Jian, Fu, Yang-Xin

“…High-dose radiation activates caspases in tumor cells to produce abundant DNA fragments for DNA sensing in antigen-presenting cells, but the intrinsic DNA…”
Get full text

DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity by Lu, Changzheng, Guan, Junhong, Lu, Steve, Jin, Qihuang, Rousseau, Benoit, Lu, Tianshi, Stephens, Dennis, Zhang, Hongyi, Zhu, Jiankun, Yang, Mingming, Ren, Zhenhua, Liang, Yong, Liu, Zhida, Han, Chuanhui, Liu, Longchao, Cao, Xuezhi, Zhang, Anli, Qiao, Jian, Batten, Kimberly, Chen, Mingyi, Castrillon, Diego H., Wang, Tao, Li, Bo, Diaz, Luis A., Li, Guo-Min, Fu, Yang-Xin

“…Increased neoantigens in hypermutated cancers with DNA mismatch repair deficiency (dMMR) are proposed as the major contributor to the high objective response…”
Get full text

Impact of different water-reducing agents on the properties of limonite self-compacting conductive concrete by Ren, Zhenhua, Guo, Jia, Chen, Wei, Zeng, Xiantao, Wang, Xiang Yu

“…The application environment for concrete is becoming increasingly complex, accompanied by an intensification of its functional requirements. This paper…”
Get full text

Seawater Corrosion Resistance of Duplex Stainless Steel and the Axial Compressive Stiffness of Its Reinforced Concrete Columns by Ren, Zhenhua, Fang, Lizheng, Wang, Hui, Ding, Peng, Zeng, Xiantao

“…In order to explore the corrosion resistance of duplex stainless steel under seawater corrosion and the compressive stiffness of its reinforced concrete…”
Get full text

Dual Targeting of Innate and Adaptive Checkpoints on Tumor Cells Limits Immune Evasion by Liu, Xiaojuan, Liu, Longchao, Ren, Zhenhua, Yang, Kaiting, Xu, Hairong, Luan, Yan, Fu, Kai, Guo, Jingya, Peng, Hua, Zhu, Mingzhao, Fu, Yang-Xin

“…CD47 on tumor cells protects from phagocytosis, while PD-L1 dampens T cell-mediated tumor killing. However, whether and how CD47 and PD-L1 coordinate is poorly…”
Get full text

Targeting IFNα to tumor by anti-PD-L1 creates feedforward antitumor responses to overcome checkpoint blockade resistance by Liang, Yong, Tang, Haidong, Guo, Jingya, Qiu, Xiangyan, Yang, Zecheng, Ren, Zhenhua, Sun, Zhichen, Bian, Yingjie, Xu, Lily, Xu, Hairong, Shen, Jiao, Han, Yanfei, Dong, Haidong, Peng, Hua, Fu, Yang-Xin

“…Many patients remain unresponsive to intensive PD-1/PD-L1 blockade therapy despite the presence of tumor-infiltrating lymphocytes. We propose that impaired…”
Get full text

Do proinflammatory cytokines play a role in clozapine-associated glycometabolism disorders? by Zhao, Tongtong, Zhang, Kai, Zhang, Yelei, Yang, Yating, Ning, Xiaoshuai, Hu, Yu, Li, Xiaoyue, Zhang, Yulong, Xia, Lei, Ren, Zhenhua, Liu, Huanzhong

“…Rationale and objective Clozapine (CLZ) is the most effective drug for treatment-resistant schizophrenia but is associated with many side effects, including…”
Get full text

Machine-Learning-Aided Prediction of Flexural Strength and ASR Expansion for Waste Glass Cementitious Composite by Sun, Junbo, Wang, Yufei, Yao, Xupei, Ren, Zhenhua, Zhang, Genbao, Zhang, Chao, Chen, Xianghong, Ma, Wei, Wang, Xiangyu

“…Waste glass (WG) is unsustainable due to its nonbiodegradable property. However, its main ingredient is silicon dioxide, which can be utilised as a…”
Get full text

Nicotine restores olfactory function by activation of prok2R/Akt/FoxO3a axis in Parkinson's disease by Guo, Qinglong, Wang, Yi, Yu, Liangchen, Guan, Liao, Ji, Xuefei, Li, Xiaohui, Pang, Gang, Ren, Zhenhua, Ye, Lei, Cheng, Hongwei

“…Olfactory dysfunction occurs frequently in Parkinson's disease (PD). In this study, we aimed to explore the potential biomarkers and underlying molecular…”
Get full text

CTLA-4 Limits Anti-CD20-Mediated Tumor Regression by Ren, Zhenhua, Guo, Jingya, Liao, Jing, Luan, Yan, Liu, Zhida, Sun, Zhichen, Liu, Xiaojuan, Liang, Yong, Peng, Hua, Fu, Yang-Xin

“…The inhibition of tumor growth by anti-CD20 antibody (Ab) treatment is mediated by Ab- and complement-dependent cytotoxicity in xenograft tumor models. In…”
Get full text

Minocycline protects developing brain against ethanol-induced damage by Wang, Xin, Zhang, Kai, Yang, Fanmuyi, Ren, Zhenhua, Xu, Mei, Frank, Jacqueline A., Ke, Zun-ji, Luo, Jia

“…Fetal alcohol spectrum disorders (FASD) are caused by ethanol exposure during the pregnancy and is the leading cause of mental retardation. Ethanol exposure…”
Get full text

Axial Compression Test and Bearing Capacity Analysis of Biaxial Prestressed Angle Steel Plate Fully Wrapped Reinforced Concrete Short Column by Ren, Zhenhua, Zeng, Xiantao, Shen, Yaqian, Huang, Huanlin

“…A new external reinforcement method is proposed in this research by using the prestressed angle steel plate to fully wrap a reinforced concrete column with a…”
Get full text

Author Correction: A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8+ T-cell response and effective tumor control by Sun, Zhichen, Ren, Zhenhua, Yang, Kaiting, Liu, Zhida, Cao, Shuaishuai, Deng, Sisi, Xu, Lily, Liang, Yong, Guo, Jingya, Bian, Yingjie, Xu, Hairong, Shi, Jiyun, Wang, Fan, Fu, Yang-Xin, Peng, Hua

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
Get full text

Test and Numerical Simulation of the Axial Compressive Capacity of Concrete Columns Reinforced by Duplex Stainless Steel Bars by Ren, Zhenhua, Wang, Hui, Fang, Lizheng, Ding, Peng, Zeng, Xiantao

“…Stainless steel has the characteristics of oxidation resistance, high temperature resistance, corrosion resistance, high strength, and high yield ratio. The…”
Get full text

Experimental Research on Axial Compression of Reinforced Concrete Short Circular Columns Strengthened with Prestressed Semicircular Steel Plates by Ren, Zhenhua, Shen, Yaqian, Zeng, Xiantao, Sun, Yuantian

“…According to the statistics of relevant departments, the total area of various existing buildings in China is at least 10 billion m2, of which about one-third…”
Get full text

Research on Electrical Conductivity and Mechanical Properties of Ecological Concrete Prepared from Mine Solid Waste by Ren, Zhenhua, Peng, Yifeng, Chen, Xi, Zeng, Hao, Zeng, Xiantao

“…Conductive concrete with nanographite–cupric nickel sulfate ore was prepared in this paper. As a new type of multifunctional multiphase conductive building…”
Get full text

Henoch-Schönlein purpura with acute pancreatitis: analysis of 13 cases by Zhang, Qin, Guo, Qi, Gui, Ming, Ren, Zhenhua, Hu, Bo, Lu, Ling, Deng, Fang

“…Henoch-Schönlein purpura is a common small vessel vasculitis in children. Acute pancreatitis rarely presents as a complication of Henoch-Schönlein purpura and…”
Get full text