Search Results - "Ren, Zhengnan"

PRMT5 critically mediates TMAO-induced inflammatory response in vascular smooth muscle cells by Liu, He, Jia, Kunpeng, Ren, Zhengnan, Sun, Jia, Pan, Li-Long

“…A high plasma level of the choline-derived metabolite trimethylamine N-oxide (TMAO) is closely related to the development of cardiovascular disease. However,…”
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G protein coupled receptor 41 regulates fibroblast activation in pulmonary fibrosis via Gαi/o and downstream Smad2/3 and ERK1/2 phosphorylation by Ren, Zhengnan, Pan, Xiaohua, Li, Jiahong, Dong, Xiaoliang, Tu, Xing, Pan, Li-Long, Sun, Jia

“…Pulmonary fibrosis is a progressive and fatal fibrotic lung disease with mysterious pathogenesis and limited effective therapies. G protein-coupled receptors…”
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Combinatory antibiotic treatment protects against experimental acute pancreatitis by suppressing gut bacterial translocation to pancreas and inhibiting NLRP3 inflammasome pathway by Jia, Lingling, Chen, Hao, Yang, Jun, Fang, Xin, Niu, Wenying, Zhang, Ming, Li, Jiahong, Pan, Xiaohua, Ren, Zhengnan, Sun, Jia, Pan, Li-Long

“…Gut bacterial translocation following impaired gut barrier is a critical determinant of initiating and aggravating acute pancreatitis (AP). Antibiotic…”
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A Novel Derivative of the Natural Product Danshensu Suppresses Inflammatory Responses to Alleviate Caerulein-Induced Acute Pancreatitis by Ren, Zhengnan, Li, Hongli, Zhang, Miaoying, Zhao, Yalei, Fang, Xin, Li, Xiu, Chen, Wei, Zhang, Hao, Wang, Yang, Pan, Li-Long, Sun, Jia

“…Acute pancreatitis (AP), a common abdominal inflammatory disorder, is characterized by premature intracellular activation of digestive proteases within…”
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Gut microbiota‐CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten‐induced enteropathy by Ren, Zhengnan, Pan, Li‐Long, Huang, Yiwen, Chen, Hongbing, Liu, Yu, Liu, He, Tu, Xing, Liu, Yanyan, Li, Binbin, Dong, Xiaoliang, Pan, Xiaohua, Li, Hanfei, Fu, Yu V, Agerberth, Birgitta, Diana, Julien, Sun, Jia

“…In the gut, cathelicidin‐related antimicrobial peptide (CRAMP) has been largely described for its anti‐infective activities. With an increasing recognition of…”
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Effect of exogenous γ-aminobutyric acid treatment on the enzymatic browning of fresh-cut potato during storage by Gao, Haiyan, Zeng, Qing, Ren, Zhengnan, Li, Peizhong, Xu, Xinxing

“…The aim of this study was to evaluate the effect of γ-aminobutyric acid (GABA) treatment on the enzymatic browning of fresh-cut potatoes. The browning index…”
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Biochanin A ameliorates caerulein-induced acute pancreatitis and associated intestinal injury in mice by inhibiting TLR4 signaling by Pan, Xiaohua, Ye, Liya, Ren, Zhengnan, Li, Jiahong, Li, Binbin, Pan, Li-Long, Sun, Jia

“…Acute pancreatitis (AP) is an acute inflammatory abdominal disease frequently associated with intestinal barrier dysfunction. Biochanin A (BCA), a dietary…”
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Opportunities and challenges of polyphenols and polysaccharides for type 1 diabetes intervention by Li, Binbin, Pan, Li-Long, Pan, Xiaohua, Dong, Xiaoliang, Ren, Zhengnan, Zhang, Hao, Chen, Wei, de Vos, Paul, Sun, Jia

“…Type 1 diabetes (T1D) is an autoimmune disorder characterized by the destruction of insulin-producing pancreatic β cell. It contributes to high mortality,…”
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Butyrate Ameliorates Antibiotic-Driven Type 1 Diabetes in the Female Offspring of Nonobese Diabetic Mice by Jia, Lingling, Cao, Minkai, Chen, Hao, Zhang, Ming, Dong, Xiaoliang, Ren, Zhengnan, Sun, Jia, Pan, Li-Long

“…Maternal gut dysbiosis affects the development of the offspring immune system. Our previous study has indicated that microbial metabolite butyrate directly…”
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Oral Delivery of Mouse β‑Defensin 14 (mBD14)-Producing Lactococcus lactis NZ9000 Attenuates Experimental Colitis in Mice by Tian, Haizhi, Li, Jiahong, Chen, Xiaopei, Ren, Zhengnan, Pan, Xiaohua, Huang, Weining, Bhatia, Madhav, Pan, Li-Long, Sun, Jia

“…Antimicrobial peptides (AMPs) play essential roles in maintaining intestinal health and have been suggested as possible therapeutic strategies against…”
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Protein arginine methyltransferase 2 (PRMT2) promotes dextran sulfate sodium‐induced colitis by inhibiting the SOCS3 promoter via histone H3R8 asymmetric dimethylation by Li, Jiahong, Pan, Xiaohua, Ren, Zhengnan, Li, Binbin, Liu, He, Wu, Chengfei, Dong, Xiaoliang, Vos, Paul, Pan, Li‐Long, Sun, Jia

“…Background and Purpose There is emerging evidence for a critical role for epigenetic modifiers in the development of inflammatory bowel disease (IBD). Protein…”
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Protein arginine methyltransferase 5–mediated arginine methylation stabilizes Kruppel-like factor 4 to accelerate neointimal formation by Liu, He, Dong, Xiaoliang, Jia, Kunpeng, Yuan, Baohui, Ren, Zhengnan, Pan, Xiaohua, Wu, Jianjin, Li, Jiahong, Zhou, Jingwen, Wang, Ru-Xing, Qu, Lefeng, Sun, Jia, Pan, Li-Long

“…Abstract Aims Accumulating evidence supports the indispensable role of protein arginine methyltransferase 5 (PRMT5) in the pathological progression of several…”
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GPR109A deficiency promotes IL‐33 overproduction and type 2 immune response in food allergy in mice by Pan, Li‐Long, Ren, Zhengnan, Tu, Xing, Liu, He, Tay, Hock L, Li, Jiahong, Pan, Xiaohua, Dong, Xiaoliang, Foster, Paul S, Sun, Jia

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Enteral virus depletion modulates experimental acute pancreatitis via toll-like receptor 9 signaling by Li, Jiahong, Pan, Xiaohua, Yang, Jun, Jia, Lingling, Wu, Chengfei, Liu, He, Ren, Zhengnan, Pan, Li-Long, Sun, Jia

“…[Display omitted] Enteric viruses that inhabit the intestine have profound effects on innate and adaptive immunity of the gut and thus distant organs. Acute…”
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Cathelicidin‐related antimicrobial peptide protects against ischaemia reperfusion‐induced acute kidney injury in mice by Pan, Li‐Long, Liang, Wenjie, Ren, Zhengnan, Li, Chunqing, Chen, Yong, Niu, Wenying, Fang, Xin, Liu, Yanyan, Zhang, Ming, Diana, Julien, Agerberth, Birgitta, Sun, Jia

“…Background and Purpose Despite recent advances in understanding its pathophysiology, treatment of acute kidney injury (AKI) remains a major unmet medical need,…”
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A novel danshensu derivative ameliorates experimental colitis by modulating NADPH oxidase 4‐dependent NLRP3 inflammasome activation by Pan, Li‐Long, Ren, Zhengnan, Liu, Yanyan, Zhao, Yalei, Li, Hongli, Pan, Xiaohua, Fang, Xin, Liang, Wenjie, Wang, Yang, Yang, Jun, Sun, Jia

“…We have previously reported a novel compound [4‐(2‐acetoxy‐3‐((R)‐3‐(benzylthio)‐1‐methoxy‐1‐oxopropan‐2‐ylamino)‐3‐oxopropyl)‐1,2‐phenylene diacetate (DSC)],…”
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Cathelicidin-related antimicrobial peptide protects against enteric pathogen-accelerated type 1 diabetes in mice by Jia, Lingling, Li, Jiahong, Zhang, Ming, Liu, He, Ren, Zhengnan, Dong, Xiao Liang, Pan, Xiaohua, Qiu, Ju, Pan, Li-Long, Sun, Jia

“…Gut barrier disruption caused by enteric pathogen infection results in activated diabetogenic T cells and accelerated type 1 diabetes (T1D)…”
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PRMT5-mediated arginine methylation stabilizes KLF4 to accelerate neointimal formation by Liu, He, Dong, Xiaoliang, Jia, Kunpeng, Yuan, Baohui, Ren, Zhengnan, Pan, Xiaohua, Wu, Jianjin, Li, Jiahong, Zhou, Jingwen, Wang, Ru-Xing, Qu, Lefeng, Sun, Jia, Pan, Li-Long

“…Accumulating evidence supports an indispensable role of protein arginine methyltransferase 5 (PRMT5) in the pathological progression of several human cancers…”
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The anti-microbial peptide LL-37/CRAMP levels are associated with acute heart failure and can attenuate cardiac dysfunction in multiple preclinical models of heart failure by Zhou, Qiulian, Pan, Li-Long, Xue, Ruicong, Ni, Gehui, Duan, Yi, Bai, Yuzheng, Shi, Chao, Ren, Zhengnan, Wu, Chengfei, Li, Guoping, Agerberth, Birgitta, Sluijter, Joost Pg, Sun, Jia, Xiao, Junjie

“…: Biomarkers for the diagnosis of heart failure (HF) are clinically essential. Circulating antimicrobial peptides LL-37 has emerged as a novel biomarker in…”
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一种基于BALB/c背景由膳食麸质引起的乳糜泻小鼠模型的构建及其评价 by 宋东筱, 任正楠, 潘礼龙, 孙嘉

“…TS201.4; 目的:利用麸质诱导建立小鼠乳糜泻(celiac…”
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