Search Results - "Ren, Xuxin"
-
1
Eliminating METTL1-mediated accumulation of PMN-MDSCs prevents hepatocellular carcinoma recurrence after radiofrequency ablation
Published in Hepatology (Baltimore, Md.) (01-04-2023)“…Radiofrequency ablation (RFA) is an important curative therapy in hepatocellular carcinoma (HCC), but recurrence rate remains as high as all the other HCC…”
Get full text
Journal Article -
2
METTL1 promotes hepatocarcinogenesis via m7G tRNA modification‐dependent translation control
Published in Clinical and translational medicine (01-12-2021)“…Background N7‐methylguanosine (m7G) modification is one of the most common transfer RNA (tRNA) modifications in humans. The precise function and molecular…”
Get full text
Journal Article -
3
Pretreatment of Grape Seed Proanthocyanidin Extract Exerts Neuroprotective Effect in Murine Model of Neonatal Hypoxic-ischemic Brain Injury by Its Antiapoptotic Property
Published in Cellular and molecular neurobiology (01-10-2019)“…Grape seed proanthocyanidin extract (GSPE), an active component extracted from the grape, has been reported to demonstrate antioxidant, anti-inflammatory,…”
Get full text
Journal Article -
4
The activation of mTOR signalling modulates DNA methylation by enhancing DNMT1 translation in hepatocellular carcinoma
Published in Journal of translational medicine (23-04-2023)“…Both dysregulation of mechanistic target of rapamycin (mTOR) signalling and DNA methylation patterns have been shown to be closely associated with tumor…”
Get full text
Journal Article -
5
Cross-talk between Myeloid and B Cells Shapes the Distinct Microenvironments of Primary and Secondary Liver Cancer
Published in Cancer research (Chicago, Ill.) (01-11-2023)“…Abstract The tumor microenvironment is distinctive in primary and secondary liver cancer. B cells represent an important component of immune infiltrates. Here,…”
Get full text
Journal Article -
6
-
7
-
8
Targeting tumour-intrinsic N 7 -methylguanosine tRNA modification inhibits MDSC recruitment and improves anti-PD-1 efficacy
Published in Gut (01-08-2023)“…Intrahepatic cholangiocarcinoma (ICC) exhibits very low response rate to immune checkpoint inhibitors (ICIs) and the underlying mechanism is largely unknown…”
Get more information
Journal Article -
9
METTL5-mediated 18S rRNA m6A modification promotes oncogenic mRNA translation and intrahepatic cholangiocarcinoma progression
Published in Molecular therapy (01-11-2023)“…Intrahepatic cholangiocarcinoma (ICC) is a deadly cancer with rapid tumor progression. While hyperactive mRNA translation caused by mis-regulated mRNA or tRNA…”
Get full text
Journal Article -
10
Crosstalk between myeloid and B cells shapes the distinct microenvironments of primary and secondary liver cancer
Published in Cancer research (Chicago, Ill.) (23-06-2023)“…The tumor microenvironment is distinctive in primary and secondary liver cancer. B cells represent an important component of immune infiltrates. Here, we…”
Get full text
Journal Article -
11
Intratumoral erythroblastic islands restrain anti-tumor immunity in hepatoblastoma
Published in Cell reports. Medicine (16-05-2023)“…Erythroblastic islands (EBIs) are the specialized structures for erythropoiesis, but they have never been found functional in tumors. As the most common…”
Get full text
Journal Article -
12
Decreased expression of ubiquilin‑1 following neonatal hypoxia‑ischemic brain injury in mice
Published in Molecular medicine reports (01-06-2019)“…Ubiquilin‑1 (Ubqln), a ubiquitin‑like protein, regulates degradation of misfolded proteins and has been reported to have a crucial role in multiple pathologic…”
Get full text
Journal Article -
13
METTL1 promotes hepatocarcinogenesis via m 7 G tRNA modification-dependent translation control
Published in Clinical and translational medicine (01-12-2021)“…N -methylguanosine (m G) modification is one of the most common transfer RNA (tRNA) modifications in humans. The precise function and molecular mechanism of m…”
Get full text
Journal Article