Search Results - "Ren, Shelly X."

N-in-1 dosing pharmacokinetics in drug discovery: experience, theoretical and practical considerations by He, Kan, Qian, Mingxin, Wong, Harvey, Bai, Stephen A, He, Bing, Brogdon, Bernice, Grace, James E, Xin, Baomin, Wu, Jingtao, Ren, Shelly X, Zeng, Hang, Deng, Yuzhong, Graden, Danielle M, Olah, Timothy V, Unger, Steve E, Luettgen, Joseph M, Knabb, Robert M, Pinto, Donald J, Lam, Patrick Y S, Duan, James, Wexler, Ruth R, Decicco, Carl P, Christ, David D, Grossman, Scott J

“…N-in-1 (or cassette) dosing pharmacokinetics (PK) has been used in drug discovery for rapid assessment of PK properties of new chemical entities. However,…”
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Anxiolytic-like effects of the corticotropin-releasing factor1 (CRF1) antagonist DMP904 [4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine] administered acutely or chronically at doses occupying central CRF1 receptors in rats by Lelas, Snjezana, Wong, Harvey, Li, Yu-Wen, Heman, Karen L, Ward, Kathryn A, Zeller, Kim L, Sieracki, Kristine K, Polino, Joseph L, Godonis, Helen E, Ren, Shelly X, Yan, Xiao-Xin, Arneric, Stephen P, Robertson, David W, Hartig, Paul R, Grossman, Scott, Trainor, George L, Taub, Rebecca A, Zaczek, Robert, Gilligan, Paul J, McElroy, John F

“…Corticotropin-releasing factor(1) (CRF(1)) antagonists may be effective in the treatment of anxiety disorders with fewer side effects compared with classic…”
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Discovery of (R)-4-(8-Fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide (BMS-694153): A Potent Antagonist of the Human Calcitonin Gene-Related Peptide Receptor for Migraine with Rapid and Efficient Intranasal Exposure by Degnan, Andrew P, Chaturvedula, Prasad V, Conway, Charles M, Cook, Deborah A, Davis, Carl D, Denton, Rex, Han, Xiaojun, Macci, Robert, Mathias, Neil R, Moench, Paul, Pin, Sokhom S, Ren, Shelly X, Schartman, Richard, Signor, Laura J, Thalody, George, Widmann, Kimberly A, Xu, Cen, Macor, John E, Dubowchik, Gene M

“…Calcitonin gene-related peptide (CGRP) has been implicated in the pathogenesis of migraine. Early chemistry leads suffered from modest potency, significant…”
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The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 1 by Han, Xiaojun, Civiello, Rita L., Conway, Charles M., Cook, Deborah A., Davis, Carl D., Macci, Robert, Pin, Sokhom S., Ren, Shelly X., Schartman, Richard, Signor, Laura J., Thalody, George, Widmann, Kimberly A., Xu, Cen, Chaturvedula, Prasad V., Macor, John E., Dubowchik, Gene M.

“…We have systematically studied the effects of varying the central unnatural amino acid moiety on CGRP receptor antagonist potency and CYP inhibition in a…”
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Discovery of (R)-4-(8-Fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidm-1-yl)piperidin-1-yl)propan-2-ylpiperidine-1-carboxamide (BMS-694153) : A Potent Antagonist of the Human Calcitonin Gene-Related Peptide Receptor for Migraine with Rapid and Efficient Intranasal Exposure by DEGNAN, Andrew P, CHATURVEDULA, Prasad V, PIN, Sokhom S, REN, Shelly X, SCHARTMAN, Richard, SIGNOR, Laura J, THALODY, George, WIDMANN, Kimberly A, CEN XU, MACOR, John E, DUBOWCHIK, Gene M, CONWAY, Charles M, COOK, Deborah A, DAVIS, Carl D, DENTON, Rex, XIAOJUN HAN, MACCI, Robert, MATHIAS, Neil R, MOENCH, Paul

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Preparation of nanometer-size dispersions of iron in sapphire by ion implantation and annealing by McHargue, Carl J., Ren, Shelly X., Sklad, P.S., Allard, L.F., Hunn, John

“…Some of the metal ions implanted into sapphire (α-Al 2O 3) are often present as metallic colloids or dispersions. Nano-composites of iron colloids in sapphire…”
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Nanometer-size dispersions of iron in sapphire produced by ion implantation by McHargue, Carl J., Ren, Shelly X., Allard, L.F., Chen, Y., Hunn, J., Williams, R.K., Perez, A., Marest, G.

“…Some of the metals ions implanted into sapphire may be present as metallic colloids. In the case of 160 keV iron implanted at room temperature, the metal…”
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