Search Results - "Ren, Jianan"

Microbiota-Immune Interaction in the Pathogenesis of Gut-Derived Infection by Wang, Chenyang, Li, Qiurong, Ren, Jianan

“…Gut-derived infection is among the most common complications in patients who underwent severe trauma, serious burn, major surgery, hemorrhagic shock or severe…”
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Circulating mitochondrial DNA-triggered autophagy dysfunction via STING underlies sepsis-related acute lung injury by Liu, Qinjie, Wu, Jie, Zhang, Xufei, Li, Xuanheng, Wu, Xiuwen, Zhao, Yun, Ren, Jianan

“…The STING pathway and its induction of autophagy initiate a potent immune defense response upon the recognition of pathogenic DNA. However, this protective…”
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Magnesium protects against sepsis by blocking gasdermin D N-terminal-induced pyroptosis by Wang, Dingyu, Zheng, Jiashuo, Hu, Qiongyuan, Zhao, Cheng, Chen, Qianyue, Shi, Peiliang, Chen, Qin, Zou, Yujie, Zou, Dayuan, Liu, Qiyao, Pei, Jingwen, Wu, Xiuwen, Gao, Xiang, Ren, Jianan, Lin, Zhaoyu

“…Hypomagnesemia is a significant risk factor for critically ill patients to develop sepsis, a life-threatening disease with a mortality rate over 25%. Our…”
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mtDNA-STING pathway promotes necroptosis-dependent enterocyte injury in intestinal ischemia reperfusion by Zhang, Xufei, Wu, Jie, Liu, Qinjie, Li, Xuanheng, Li, Sicheng, Chen, Jun, Hong, Zhiwu, Wu, Xiuwen, Zhao, Yun, Ren, Jianan

“…Intestinal ischemia reperfusion (I/R) injury is the important pathogenesis for acute intestinal barrier disruption. The STING signaling is associated with gut…”
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Microfluidic generation of egg-derived protein microcarriers for 3D cell culture and drug delivery by Liu, Yuxiao, Huang, Qian, Wang, Jie, Fu, Fanfan, Ren, Jianan, Zhao, Yuanjin

“…Microcarriers have a demonstrated value for biomedical applications,in particular for drug delivery and three-dimensional cell culture.Attempts to develop this…”
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Prospective multicenter study on the incidence of surgical site infection after emergency abdominal surgery in China by Li, Ze, Li, Hui, Lv, Pin, Peng, Xingang, Wu, Changliang, Ren, Jianan, Wang, Peige

“…There is still a lack of relevant studies on surgical site infection (SSI) after emergency abdominal surgery (EAS) in China. This study aims to understand the…”
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Extracellular vesicles package dsDNA to aggravate Crohn’s disease by activating the STING pathway by Zhao, Fan, Zheng, Tao, Gong, Wenbin, Wu, Jie, Xie, Haohao, Li, Weijie, Zhang, Rui, Liu, Peizhao, Liu, Juanhan, Wu, Xiuwen, Zhao, Yun, Ren, Jianan

“…Crohn’s disease (CD) is an intestinal immune-dysfunctional disease. Extracellular vesicles (EVs) are membrane-enclosed particles full of functional molecules,…”
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Injectable in situ cross-linking chitosan-hyaluronic acid based hydrogels for abdominal tissue regeneration by Deng, Youming, Ren, Jianan, Chen, Guopu, Li, Guanwei, Wu, Xiuwen, Wang, Gefei, Gu, Guosheng, Li, Jieshou

“…Abdominal wall defect caused by open abdomen (OA) or abdominal trauma is a serious issue since it induces several clinical problems. Although a variety of…”
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New WHO recommendations on intraoperative and postoperative measures for surgical site infection prevention: an evidence-based global perspective by Allegranzi, Benedetta, Dr, Zayed, Bassim, MD, Bischoff, Peter, MD, Kubilay, N Zeynep, MD, de Jonge, Stijn, MD, de Vries, Fleur, MD, Gomes, Stacey M, MS, Gans, Sarah, MD, Wallert, Elon D, BSc, Wu, Xiuwen, MD, Abbas, Mohamed, MD, Boermeester, Marja A, Prof, Dellinger, E Patchen, Prof, Egger, Matthias, Prof, Gastmeier, Petra, Prof, Guirao, Xavier, MD, Ren, Jianan, Prof, Pittet, Didier, Prof, Solomkin, Joseph S, Prof

“…Summary Surgical site infections (SSIs) are the most common health-care-associated infections in developing countries, but they also represent a substantial…”
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A click chemistry-mediated all-peptide cell printing hydrogel platform for diabetic wound healing by Huang, Jinjian, Yang, Rong, Jiao, Jiao, Li, Ze, Wang, Penghui, Liu, Ye, Li, Sicheng, Chen, Canwen, Li, Zongan, Qu, Guiwen, Chen, Kang, Wu, Xiuwen, Chi, Bo, Ren, Jianan

“…High glucose-induced vascular endothelial injury is a major pathological factor involved in non-healing diabetic wounds. To interrupt this pathological…”
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GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity by Chen, Qin, Shi, Peiliang, Wang, Yufang, Zou, Dayuan, Wu, Xiuwen, Wang, Dingyu, Hu, Qiongyuan, Zou, Yujie, Huang, Zan, Ren, Jianan, Lin, Zhaoyu, Gao, Xiang

“…Abstract Gasdermin B (GSDMB) has been reported to be associated with immune diseases in humans, but the detailed molecular mechanisms remain unsolved. The…”
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The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages by Wu, Jie, Liu, Qinjie, Zhang, Xufei, Tan, Miaomiao, Li, Xuanheng, Liu, Peizhao, Wu, Lei, Jiao, Fan, Lin, Zhaoyu, Wu, Xiuwen, Wang, Xin, Zhao, Yun, Ren, Jianan

“…The discovery of STING-related innate immunity has recently provided a deep mechanistic understanding of immunopathy. While the detrimental effects of STING…”
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Post-Translational Modifications of STING: A Potential Therapeutic Target by Kang, Jiaqi, Wu, Jie, Liu, Qinjie, Wu, Xiuwen, Zhao, Yun, Ren, Jianan

“…Stimulator of interferon genes (STING) is an endoplasmic-reticulum resident protein, playing essential roles in immune responses against microbial infections…”
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Hesperidin Protects Against Intestinal Inflammation by Restoring Intestinal Barrier Function and Up‐Regulating Treg Cells by Guo, Kun, Ren, Jianan, Gu, Guosheng, Wang, Gefei, Gong, Wenbin, Wu, Xiuwen, Ren, Huajian, Hong, Zhiwu, Li, Jieshou

“…Scope Hesperidin is an important natural phenolic compound and is considered beneficial to health. The purpose of this study is to investigate the protective…”
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Intestinal mucosa-derived DNA methylation signatures in the penetrating intestinal mucosal lesions of Crohn’s disease by Li, Yuan, Wang, Zhiming, Wu, Xiuwen, Wang, Gefei, Gu, Guosheng, Ren, Huajian, Hong, Zhiwu, Ren, Jianan

“…The purpose of this study was to evaluate genome-wide DNA methylation changes in intestinal mucosa tissue of adult patients with Crohn's disease…”
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Risk factors and clinical outcomes of hypervirulent Klebsiella pneumoniae induced bloodstream infections by Li, Jiayang, Ren, Jianan, Wang, Weiping, Wang, Gefei, Gu, Guosheng, Wu, Xiuwen, Wang, Ying, Huang, Mei, Li, Jieshou

“…The prevalence of hypervirulent Klebsiella pneumoniae (hvKP) is high in China, but clinical characteristics and outcomes of hvKP induced bloodstream infections…”
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Microfluidic Electrospray Niacin Metal-Organic Frameworks Encapsulated Microcapsules for Wound Healing by Chen, Guopu, Yu, Yunru, Wu, Xiuwen, Wang, Gefei, Gu, Guosheng, Wang, Feng, Ren, Jianan, Zhang, Huidan, Zhao, Yuanjin

“…Niacin metal-organic frameworks (MOFs) encapsulated microcapsules with alginate shells and copper-/zinc-niacin framework cores were synthesized by using a…”
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The Role of Mitochondrial DNA in the Development of Ischemia Reperfusion Injury by Hu, Qiongyuan, Zhou, Quan, Wu, Jie, Wu, Xiuwen, Ren, Jianan

“…ABSTRACTIschemia/reperfusion (I/R) injury is a common occurrence resulting from acute mesenteric ischemia, traumatic or septic shock, burns, and surgical…”
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Released Mitochondrial DNA Following Intestinal Ischemia Reperfusion Induces the Inflammatory Response and Gut Barrier Dysfunction by Hu, Qiongyuan, Ren, Huajian, Ren, Jianan, Liu, Qinjie, Wu, Jie, Wu, Xiuwen, Li, Guanwei, Wang, Gefei, Gu, Guosheng, Guo, Kun, Hong, Zhiwu, Liu, Song, Li, Jieshou

“…Ischemia-reperfusion (I/R) injury is a challenging clinical problem, especially injuries involving the gastrointestinal tract. Mitochondrial DNA (mtDNA) is…”
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4-octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING by Li, Weizhen, Li, Yangguang, Kang, Jiaqi, Jiang, Haiyang, Gong, Wenbin, Chen, Lijuan, Wu, Cunxia, Liu, Mingda, Wu, Xiuwen, Zhao, Yun, Ren, Jianan

“…The Krebs cycle-derived metabolite itaconate, whose production is catalyzed by immune response gene 1 (IRG1), has potential to link immunity and metabolism in…”
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