Search Results - "Ren, Cynthia"
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Connexin43 Forms Supramolecular Complexes through Non-Overlapping Binding Sites for Drebrin, Tubulin, and ZO-1
Published in PloS one (09-06-2016)“…Gap junctions are membrane specialization domains identified in most tissue types where cells abut each other. The connexin channels found in these membrane…”
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Electron Microscopic Analysis of Lens Gap Junction Connexin50 Hemichannels and Channels
Published in The FASEB journal (01-04-2015)“…Abstract only The mammalian lens is an avascular organelle that depends on gap junction (GJ) mediated intercellular communication for homeostasis, growth and…”
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Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X‑Ray Cocrystallography
Published in Journal of medicinal chemistry (11-01-2024)“…SOS1 and SOS2 are guanine nucleotide exchange factors that mediate RTK-stimulated RAS activation. Selective SOS1:KRAS PPI inhibitors are currently under…”
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