Search Results - "Remy‐Jouet, Isabelle"

Mitochondrial Dysfunction as an Arrhythmogenic Substrate by Montaigne, David, MD, PhD, Marechal, Xavier, PhD, Lefebvre, Philippe, PhD, Modine, Thomas, MD, PhD, Fayad, Georges, MD, Dehondt, Helene, Eng, Hurt, Christopher, MD, Coisne, Augustin, MD, Koussa, Mohamed, MD, Remy-Jouet, Isabelle, PhD, Zerimech, Farid, MD, Boulanger, Eric, MD, PhD, Lacroix, Dominique, MD, PhD, Staels, Bart, PhD, Neviere, Remi, MD, PhD

“…Objectives This study sought to provide bedside evidence of the potential link between cardiac mitochondrial dysfunction and arrhythmia as reported in bench…”
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The IL-1β Antibody Gevokizumab Limits Cardiac Remodeling and Coronary Dysfunction in Rats With Heart Failure by Harouki, Najah, BS, Nicol, Lionel, PhD, Remy-Jouet, Isabelle, PhD, Henry, Jean-Paul, BS, Dumesnil, Anais, BS, Lejeune, Annie, BS, Renet, Sylvanie, BS, Golding, Francesca, BS, Djerada, Zoubir, PhD, Wecker, Didier, PhD, Bolduc, Virginie, PhD, Bouly, Muriel, PhD, Roussel, Jerome, PhD, Richard, Vincent, PhD, Mulder, Paul, PhD

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Transient heart rate reduction improves acute decompensated heart failure‐induced left ventricular and coronary dysfunction by Peschanski, Nicolas, Harouki, Najah, Soulie, Matthieu, Lachaux, Marianne, Nicol, Lionel, Remy‐Jouet, Isabelle, Henry, Jean‐Paul, Dumesnil, Anais, Renet, Sylvanie, Fougerousse, Françoise, Brakenhielm, Ebba, Ouvrard‐Pascaud, Antoine, Thuillez, Christian, Richard, Vincent, Roussel, Jérôme, Mulder, Paul

“…Aims Acute decompensated heart failure (ADHF), a live‐threatening complication of heart failure (HF), associates a further decrease of the already by…”
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Evidence for a Role of Vascular Endothelium in the Control of Arterial Wall Viscosity in Humans by Roca, Frederic, Iacob, Michele, Remy-Jouet, Isabelle, Bellien, Jeremy, Joannides, Robinson

“…Arterial wall viscosity (AWV) is a major cause of energy dissipation along the arterial tree. Its determinants remain controversial but an active endothelial…”
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IFNγ causes mitochondrial dysfunction and oxidative stress in myositis by Abad, Catalina, Pinal-Fernandez, Iago, Guillou, Clement, Bourdenet, Gwladys, Drouot, Laurent, Cosette, Pascal, Giannini, Margherita, Debrut, Lea, Jean, Laetitia, Bernard, Sophie, Genty, Damien, Zoubairi, Rachid, Remy-Jouet, Isabelle, Geny, Bernard, Boitard, Christian, Mammen, Andrew, Meyer, Alain, Boyer, Olivier

“…Idiopathic inflammatory myopathies (IIMs) are severe autoimmune diseases with poorly understood pathogenesis and unmet medical needs. Here, we examine the role…”
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Short‐ and long‐term administration of the non‐steroidal mineralocorticoid receptor antagonist finerenone opposes metabolic syndrome‐related cardio‐renal dysfunction by Lachaux, Marianne, Barrera‐Chimal, Jonatan, Nicol, Lionel, Rémy‐Jouet, Isabelle, Renet, Sylvanie, Dumesnil, Anais, Wecker, Didier, Richard, Vincent, Kolkhof, Peter, Jaisser, Frederic, Ouvrard‐Pascaud, Antoine, Mulder, Paul

“…Aim To determine whether non‐steroidal mineralocorticoid receptor (MR) antagonists oppose metabolic syndrome‐related end‐organ, i.e. cardiac, damage. Materials…”
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Polycystin deficiency induces dopamine-reversible alterations in flow-mediated dilatation and vascular nitric oxide release in humans by Lorthioir, Aurélien, Joannidès, Robinson, Rémy-Jouet, Isabelle, Fréguin-Bouilland, Caroline, Iacob, Michèle, Roche, Clothilde, Monteil, Christelle, Lucas, Danièle, Renet, Sylvanie, Audrézet, Marie-Pierre, Godin, Michel, Richard, Vincent, Thuillez, Christian, Guerrot, Dominique, Bellien, Jérémy

“…Autosomal dominant polycystic kidney disease (ADPKD) is a renal hereditary disorder associated with increased cardiovascular mortality, due to mutations in…”
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Role of Toll‐like Receptors 2 and 4 in Mediating Endothelial Dysfunction and Arterial Remodeling in Primary Arterial Antiphospholipid Syndrome by Benhamou, Ygal, Bellien, Jeremy, Armengol, Guillaume, Brakenhielm, Ebba, Adriouch, Sahil, Iacob, Michele, Remy‐Jouet, Isabelle, Le Cam‐Duchez, Véronique, Monteil, Christelle, Renet, Sylvanie, Jouen, Fabienne, Drouot, Laurent, Menard, Jean‐François, Borg, Jeanne‐Yvonne, Thuillez, Christian, Boyer, Olivier, Levesque, Hervé, Richard, Vincent, Joannidès, Robinson

“…Objective To assess the role of Toll‐like receptors (TLRs) in antiphospholipid antibody (aPL)–mediated vascular abnormalities in patients with primary arterial…”
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Impact of soluble epoxide hydrolase inhibition on early kidney damage in hyperglycemic overweight mice by Roche, Clothilde, Guerrot, Dominique, Harouki, Najah, Duflot, Thomas, Besnier, Marie, Rémy-Jouet, Isabelle, Renet, Sylvanie, Dumesnil, Anaïs, Lejeune, Annie, Morisseau, Christophe, Richard, Vincent, Bellien, Jeremy

“…•This study shows that sEH inhibition prevents the development of renal dysfunction in hyperglycemic overweight mice beyond its hypoglycemic effect.•sEH…”
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Physiological role of endothelin-1 in flow-mediated vasodilatation in humans and impact of cardiovascular risk factors by Bellien, Jérémy, Iacob, Michèle, Monteil, Christelle, Rémy-Jouet, Isabelle, Roche, Clothilde, Duflot, Thomas, Vendeville, Cathy, Gutierrez, Laurence, Thuillez, Christian, Richard, Vincent, Joannidès, Robinson

“…The current study addressed the hypothesis that the local decrease in endothelin-1 (ET-1) bioavailability during sustained flow increases contributes to…”
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Short‐and long‐term administration of imeglimin counters cardiorenal dysfunction in a rat model of metabolic syndrome by Lachaux, Marianne, Soulié, Matthieu, Hamzaoui, Mouad, Bailly, Anaëlle, Nicol, Lionel, Rémy‐Jouet, Isabelle, Renet, Sylvanie, Vendeville, Cathy, Gluais‐Dagorn, Pascale, Hallakou‐Bozec, Sophie, Monteil, Christelle, Richard, Vincent, Mulder, Paul

“…Introduction Imeglimin, a glucose‐lowering agent targeting mitochondrial bioenergetics, decreases reactive oxygen species (ROS) overproduction and improves…”
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Coronary endothelial dysfunction after cardiomyocyte-specific mineralocorticoid receptor overexpression by Favre, Julie, Gao, Ji, Zhang, An Di, Remy-Jouet, Isabelle, Ouvrard-Pascaud, Antoine, Dautreaux, Brigitte, Escoubet, Brigitte, Thuillez, Christian, Jaisser, Frédéric, Richard, Vincent

“…The deleterious effects of aldosterone excess demonstrated in cardiovascular diseases might be linked in part to coronary vascular dysfunction. However,…”
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Altered bioavailability of epoxyeicosatrienoic acids is associated with conduit artery endothelial dysfunction in type 2 diabetic patients by Duflot, Thomas, Moreau-Grangé, Lucile, Roche, Clothilde, Iacob, Michèle, Wils, Julien, Rémy-Jouet, Isabelle, Cailleux, Anne-Françoise, Leuillier, Matthieu, Renet, Sylvanie, Li, Dongyang, Morisseau, Christophe, Lamoureux, Fabien, Richard, Vincent, Prévost, Gaëtan, Joannidès, Robinson, Bellien, Jérémy

“…This pathophysiological study addressed the hypothesis that soluble epoxide hydrolase (sEH), which metabolizes the vasodilator and anti-inflammatory…”
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Beneficial Effects of Remifentanil Against Excitotoxic Brain Damage in Newborn Mice by Chollat, Clément, Lecointre, Maryline, Leuillier, Matthieu, Remy-Jouet, Isabelle, Do Rego, Jean-Claude, Abily-Donval, Lénaïg, Ramdani, Yasmina, Richard, Vincent, Compagnon, Patricia, Dureuil, Bertrand, Marret, Stéphane, Gonzalez, Bruno José, Jégou, Sylvie, Tourrel, Fabien

“…Remifentanil, a synthetic opioid used for analgesia during cesarean sections, has been shown in experiments to exert anti-apoptotic activity on immature mice…”
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Selective Heart Rate Reduction Improves Metabolic Syndrome–related Left Ventricular Diastolic Dysfunction by Merabet, Nassiba, Fang, Yuehua, Nicol, Lionel, Monteil, Christelle, Rémy-Jouet, Isabelle, Henry, Jean-Paul, Wecker, Didier, Le Bouter-Banon, Sabrina, Roussel, Jerome, Richard, Vincent, Thuillez, Christian, Mulder, Paul

“…BACKGROUND:Enhanced heart rate observed in metabolic syndrome (MS) contributes to the deterioration of left ventricular (LV) function via impaired LV filling…”
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NO-dependent protective effect of VEGF against excitotoxicity on layer VI of the developing cerebral cortex by El Ghazi, Faiza, Desfeux, Arnaud, Brasse-Lagnel, Carole, Roux, Christian, Lesueur, Celine, Mazur, Danielle, Remy-Jouet, Isabelle, Richard, Vincent, Jégou, Sylvie, Laudenbach, Vincent, Marret, Stephane, Bekri, Soumeya, Prevot, Vincent, Gonzalez, Bruno J

“…Abstract In industrialized countries, cerebral palsy affects 2.5‰ of preterm and term infants. At a neurochemical level, the massive release of glutamate…”
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Preventive actions to avoid questionable research practices. Use of EERM (Ethical and Efficient Research Management) during Arrival and Departure of a co-worker by Bareille, Reine, Baudouin-Massot, Béatrice, Carreno, Marie Paule, Fournier, Sandra, Lebret, Nelly, Remy-Jouet, Isabelle, Giesen, Eva

“…Preventive actions for scientific misconduct and questionable research practice must be taken at an institutional level but also by scientists themselves as…”
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Reduced cardiac remodelling and prevention of glutathione deficiency after omega-3 supplementation in chronic heart failure by Fang, Yuehua, Favre, Julie, Vercauteren, Magalie, Laillet, Brigitte, Remy-Jouet, Isabelle, Skiba, Mohamed, Lallemand, Françoise, Dehaudt, Cathy, Monteil, Christelle, Thuillez, Christian, Mulder, Paul

“…n‐3 polyunsaturated fatty acids (omega‐3) supplementation is associated with reduced cardiovascular mortality and post‐infarction death. However, the impact of…”
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High-efficiency on-line haemodiafiltration improves conduit artery endothelial function compared with high-flux haemodialysis in end-stage renal disease patients by Bellien, Jérémy, Fréguin-Bouilland, Caroline, Joannidès, Robinson, Hanoy, Mélanie, Rémy-Jouet, Isabelle, Monteil, Christelle, Iacob, Michèle, Martin, Laurent, Renet, Sylvanie, Vendeville, Cathy, Godin, Michel, Thuillez, Christian, Le Roy, Frank

“…Middle molecular weight uraemic toxins are considered to play an important role in vascular dysfunction and cardiovascular outcomes in end-stage renal disease…”
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Myocardial Contractile Dysfunction Is Associated With Impaired Mitochondrial Function and Dynamics in Type 2 Diabetic but Not in Obese Patients by Montaigne, David, Marechal, Xavier, Coisne, Augustin, Debry, Nicolas, Modine, Thomas, Fayad, Georges, Potelle, Charlotte, El Arid, Jean-Marc, Mouton, Stéphanie, Sebti, Yasmine, Duez, Hélène, Preau, Sébastien, Remy-Jouet, Isabelle, Zerimech, Farid, Koussa, Mohamed, Richard, Vincent, Neviere, Remi, Edme, Jean-Louis, Lefebvre, Philippe, Staels, Bart

“…BACKGROUND—Obesity and diabetes mellitus are independently associated with the development of heart failure. In this study, we determined the respective…”
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