Search Results - "Remy, Stefan"

A hippocampus-accumbens code guides goal-directed appetitive behavior by Barnstedt, Oliver, Mocellin, Petra, Remy, Stefan

“…The dorsal hippocampus (dHPC) is a key brain region for the expression of spatial memories, such as navigating towards a learned reward location. The nucleus…”
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Locomotion, Theta Oscillations, and the Speed-Correlated Firing of Hippocampal Neurons Are Controlled by a Medial Septal Glutamatergic Circuit by Fuhrmann, Falko, Justus, Daniel, Sosulina, Liudmila, Kaneko, Hiroshi, Beutel, Tatjana, Friedrichs, Detlef, Schoch, Susanne, Schwarz, Martin Karl, Fuhrmann, Martin, Remy, Stefan

“…Before the onset of locomotion, the hippocampus undergoes a transition into an activity-state specialized for the processing of spatially related input. This…”
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Dendritic structural degeneration is functionally linked to cellular hyperexcitability in a mouse model of Alzheimer's disease by Šišková, Zuzana, Justus, Daniel, Kaneko, Hiroshi, Friedrichs, Detlef, Henneberg, Niklas, Beutel, Tatjana, Pitsch, Julika, Schoch, Susanne, Becker, Albert, von der Kammer, Heinz, Remy, Stefan

“…Dendritic structure critically determines the electrical properties of neurons and, thereby, defines the fundamental process of input-to-output conversion. The…”
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Dendritic spikes induce single-burst long-term potentiation by Remy, Stefan, Spruston, Nelson

“…The hippocampus is essential for episodic memory, which requires single-trial learning. Although long-term potentiation (LTP) of synaptic strength is a…”
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Inhibitory Control of Linear and Supralinear Dendritic Excitation in CA1 Pyramidal Neurons by Müller, Christina, Beck, Heinz, Coulter, Douglas, Remy, Stefan

“…The transformation of dendritic excitatory synaptic inputs to axonal action potential output is the fundamental computation performed by all principal neurons…”
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Glutamatergic synaptic integration of locomotion speed via septoentorhinal projections by Justus, Daniel, Dalügge, Dennis, Bothe, Stefanie, Fuhrmann, Falko, Hannes, Christian, Kaneko, Hiroshi, Friedrichs, Detlef, Sosulina, Liudmila, Schwarz, Inna, Elliott, David Anthony, Schoch, Susanne, Bradke, Frank, Schwarz, Martin Karl, Remy, Stefan

“…The authors describe a glutamatergic septoentorhinal pathway that provides running-speed-correlated input to MEC layer 2/3. The speed signal is integrated by…”
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Identifying behavioral structure from deep variational embeddings of animal motion by Luxem, Kevin, Mocellin, Petra, Fuhrmann, Falko, Kürsch, Johannes, Miller, Stephanie R., Palop, Jorge J., Remy, Stefan, Bauer, Pavol

“…Quantification and detection of the hierarchical organization of behavior is a major challenge in neuroscience. Recent advances in markerless pose estimation…”
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Activity-Dependent Control of Neuronal Output by Local and Global Dendritic Spike Attenuation by Remy, Stefan, Csicsvari, Jozsef, Beck, Heinz

“…Neurons possess elaborate dendritic arbors which receive and integrate excitatory synaptic signals. Individual dendritic subbranches exhibit local membrane…”
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Holistic bursting cells store long-term memory in auditory cortex by Li, Ruijie, Huang, Junjie, Li, Longhui, Zhao, Zhikai, Liang, Susu, Liang, Shanshan, Wang, Meng, Liao, Xiang, Lyu, Jing, Zhou, Zhenqiao, Wang, Sibo, Jin, Wenjun, Chen, Haiyang, Holder, Damaris, Liu, Hongbang, Zhang, Jianxiong, Li, Min, Tang, Yuguo, Remy, Stefan, Pakan, Janelle M. P., Chen, Xiaowei, Jia, Hongbo

“…The sensory neocortex has been suggested to be a substrate for long-term memory storage, yet which exact single cells could be specific candidates underlying…”
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Role of Axonal NaV1.6 Sodium Channels in Action Potential Initiation of CA1 Pyramidal Neurons by Royeck, Michel, Horstmann, Marie-Therese, Remy, Stefan, Reitze, Margit, Yaari, Yoel, Beck, Heinz

“…1 Department of Epileptology, University of Bonn Medical Center, Bonn, Germany; 2 Helmholtz-Institute for Radiation and Nuclear Physics and 3 Interdisciplinary…”
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Dendritic inhibition mediated by O-LM and bistratified interneurons in the hippocampus by Müller, Christina, Remy, Stefan

“…In the CA1 region of the hippocampus pyramidal neurons and GABAergic interneurons form local microcircuits. CA1 interneurons are a diverse group consisting of…”
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Machine learning reveals prominent spontaneous behavioral changes and treatment efficacy in humanized and transgenic Alzheimer's disease models by Miller, Stephanie R., Luxem, Kevin, Lauderdale, Kelli, Nambiar, Pranav, Honma, Patrick S., Ly, Katie K., Bangera, Shreya, Bullock, Mary, Shin, Jia, Kaliss, Nick, Qiu, Yuechen, Cai, Catherine, Shen, Kevin, Mallen, K. Dakota, Yan, Zhaoqi, Mendiola, Andrew S., Saito, Takashi, Saido, Takaomi C., Pico, Alexander R., Thomas, Reuben, Roberson, Erik D., Akassoglou, Katerina, Bauer, Pavol, Remy, Stefan, Palop, Jorge J.

“…Computer-vision and machine-learning (ML) approaches are being developed to provide scalable, unbiased, and sensitive methods to assess mouse behavior. Here,…”
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Proximal Persistent Na+ Channels Drive Spike Afterdepolarizations and Associated Bursting in Adult CA1 Pyramidal Cells by Yue, Cuiyong, Remy, Stefan, Su, Hailing, Beck, Heinz, Yaari, Yoel

“…In many principal brain neurons, the fast, all-or-none Na+ spike initiated at the proximal axon is followed by a slow, graded after depolarization (ADP). The…”
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A novel mechanism underlying drug resistance in chronic epilepsy by Remy, Stefan, Gabriel, Siegrun, Urban, Bernd W., Dietrich, Dirk, Lehmann, Thomas N., Elger, Christian E., Heinemann, Uwe, Beck, Heinz

“…The development of resistance to pharmacological treatment is common to many human diseases. In chronic epilepsy, many patients develop resistance to…”
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Anticonvulsant pharmacology of voltage-gated Na+ channels in hippocampal neurons of control and chronically epileptic rats by Remy, Stefan, Urban, Bernd W., Elger, Christian E., Beck, Heinz

“…Voltage‐gated Na+ channels are a main target of many first‐line anticonvulsant drugs and their mechanism of action has been extensively investigated in cell…”
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Septo–hippocampal interaction by Müller, Christina, Remy, Stefan

“…The septo–hippocampal pathway adjusts CA1 network excitability to different behavioral states and is crucially involved in theta rhythmogenesis. In the medial…”
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A post-burst after depolarization is mediated by group i metabotropic glutamate receptor-dependent upregulation of Ca(v)2.3 R-type calcium channels in CA1 pyramidal neurons by Park, Jin-Yong, Remy, Stefan, Varela, Juan, Cooper, Donald C, Chung, Sungkwon, Kang, Ho-Won, Lee, Jung-Ha, Spruston, Nelson

“…Activation of group I metabotropic glutamate receptors (subtypes mGluR1 and mGluR5) regulates neural activity in a variety of ways. In CA1 pyramidal neurons,…”
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Dendritic Integration in Hippocampal Dentate Granule Cells by Krueppel, Roland, Remy, Stefan, Beck, Heinz

“…Hippocampal granule cells are important relay stations that transfer information from the entorhinal cortex into the hippocampus proper. This process…”
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Modelling the contributions to hyperexcitability in a mouse model of Alzheimer's disease by Mittag, Martin, Mediavilla, Laura, Remy, Stefan, Cuntz, Hermann, Jedlicka, Peter

“…Neuronal hyperexcitability is a pathological characteristic of Alzheimer's disease (AD). Three main mechanisms have been proposed to explain it: (i) dendritic…”
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Molecular and cellular mechanisms of pharmacoresistance in epilepsy by Remy, Stefan, Beck, Heinz

“…Epilepsy is a common and devastating neurological disorder. In many patients with epilepsy, seizures are well-controlled with currently available…”
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