Search Results - "Remy, Brenda"

Discrete element simulation of free flowing grains in a four-bladed mixer by Remy, Brenda, Khinast, Johannes G, Glasser, Benjamin J

“…Numerical simulations of granular flow in a cylindrical vessel agitated by a four-blade impeller were performed using the discrete element method. Velocity,…”
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Polydisperse granular flows in a bladed mixer: Experiments and simulations of cohesionless spheres by Remy, Brenda, Khinast, Johannes G., Glasser, Benjamin J.

“…The flow and segregation of polydisperse, spherical particle mixtures in a bladed mixer was investigated using experimental and computational techniques…”
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Flow of granular materials in a bladed mixer: Effect of particle properties and process parameters on impeller torque and power consumption by Boonkanokwong, Veerakiet, Frank, Rohan P., Valliappan, Pavithra, Remy, Brenda, Khinast, Johannes G., Glasser, Benjamin J.

“…[Display omitted] •Experiments were conducted on spherical glass beads flowing in a bladed mixer.•The impeller torque was measured using a rotating platform…”
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The Pharmaceutical Drying Unit Operation: An Industry Perspective on Advancing the Science and Development Approach for Scale-Up and Technology Transfer by Conder, Edward W, Cosbie, Andrew S, Gaertner, John, Hicks, William, Huggins, Seth, MacLeod, Claire S, Remy, Brenda, Yang, Bing-Shiou, Engstrom, Joshua D, Lamberto, David J, Papageorgiou, Charles D

“…The drying unit operation is used extensively in the pharmaceutical industry, but often a lack of understanding of the impact of the drying process parameters…”
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The effect of the number of impeller blades on granular flow in a bladed mixer by Boonkanokwong, Veerakiet, Remy, Brenda, Khinast, Johannes G., Glasser, Benjamin J.

“…Simulations of granular flow of monodisperse, cohesionless spherical glass beads in a cylindrical bladed mixer agitated by an impeller were performed using the…”
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Wet granular flows in a bladed mixer: Experiments and simulations of monodisperse spheres by Remy, Brenda, Khinast, Johannes G., Glasser, Benjamin J.

“…The flow and agglomeration of wet particles in a bladed mixer was studied experimentally using particle image velocimetry and computationally using the…”
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Optimization of Primary Drying in Lyophilization During Early-Phase Drug Development Using a Definitive Screening Design With Formulation and Process Factors by Goldman, Johnathan M, More, Haresh T, Yee, Olga, Borgeson, Elizabeth, Remy, Brenda, Rowe, Jasmine, Sadineni, Vikram

“…Development of optimal drug product (DP) lyophilization cycles is typically accomplished via multiple engineering runs to determine appropriate process…”
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effect of mixer properties and fill level on granular flow in a bladed mixer by Remy, Brenda, Glasser, Benjamin J, Khinast, Johannes G

“…The discrete element method was used to study the effect of mixer properties and fill level on the granular flow of monodisperse, cohesionless spheres in a…”
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All the Brazil nuts are not on top: Vibration induced granular size segregation of binary, ternary and multi-sized mixtures by Metzger, Matthew J., Remy, Brenda, Glasser, Benjamin J.

“…Vertically vibrated systems of granular materials have been used to gain insight on granular segregation for decades. However, the majority of studies have…”
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Scale-up of agitated drying: Effect of shear stress and hydrostatic pressure on active pharmaceutical ingredient powder properties by Remy, Brenda, Kightlinger, Weston, Saurer, Eric M., Domagalski, Nathan, Glasser, Benjamin J.

“…Scale‐up of agitated drying processes to minimize particle size changes in active pharmaceutical ingredients (API) can be challenging. Particle agglomeration…”
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Experiments and simulations of cohesionless particles with varying roughness in a bladed mixer by Remy, Brenda, Canty, Thomas M., Khinast, Johannes G., Glasser, Benjamin J.

“…The kinematics of granular flow of cohesionless particles in a bladed mixer was studied experimentally using particle image velocimetry and computationally…”
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Small-Scale Tools to Assess the Impact of Interfacial and Shear Stress on Biologic Drug Products by Ogunyankin, Maria O., Deshmukh, Smeet, Krause, Mary E., Carvalho, Thiago, Huang, Masano, Ilott, Andrew, Remy, Brenda, Khossravi, Mehrnaz

“…ABSTRACT Proper risk analysis needs to be in place to understand the susceptibility of protein to unfold and aggregate in the presence of interfacial and/or…”
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All the Brazil nuts are not on top: Vibration induced granular size segregation of binary, ternary and multi-sized mixtures by METZGER, Matthew J, REMY, Brenda, GLASSER, Benjamin J

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Selection of an Enantioselective Process for the Preparation of a CGRP Receptor Inhibitor by Cann, Reginald O, Chen, Chung-Pin H, Gao, Qi, Hanson, Ronald L, Hsieh, Daniel, Li, Jun, Lin, Dong, Parsons, Rodney L, Pendri, Yadagiri, Nielsen, R. Brent, Nugent, William A, Parker, William L, Quinlan, Sandra, Reising, Nathan P, Remy, Brenda, Sausker, Justin, Wang, Xuebao

“…(R)-N-(3-(7-Methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)piperazine-1-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide…”
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Granular flow, segregation and agglomeration in bladed mixers by Remy, Brenda

“…A large number of industrial processes involve the transport, mixing and storage of particulate systems. While prevalent in industry, particulate processes are…”
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Modeling-Based Approach towards On-Scale Implementation of a Methanethiol-Emitting Reaction by Remy, Brenda, Brueggemeier, Shawn, Marchut, Alex, Lyngberg, Olav, Lin, Dong, Hobson, Lindsay

“…Utilizing kinetic process modeling, the conditions for a pharmaceutical guanylation reaction were optimized to promote controlled generation of methanethiol…”
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Granular flow, segregation and agglomeration in bladed mixers by Remy, Brenda

“…A large number of industrial processes involve the transport, mixing and storage of particulate systems. While prevalent in industry, particulate processes are…”
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