Search Results - "Rems, Lea"

Membrane Electroporation and Electropermeabilization: Mechanisms and Models by Kotnik, Tadej, Rems, Lea, Tarek, Mounir, Miklav i, Damijan

“…Exposure of biological cells to high-voltage, short-duration electric pulses causes a transient increase in their plasma membrane permeability, allowing…”
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Pulsed Electric Fields Can Create Pores in the Voltage Sensors of Voltage-Gated Ion Channels by Rems, Lea, Kasimova, Marina A., Testa, Ilaria, Delemotte, Lucie

“…Pulsed electric fields are increasingly used in medicine to transiently increase the cell membrane permeability via electroporation to deliver therapeutic…”
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Actin networks regulate the cell membrane permeability during electroporation by Muralidharan, Aswin, Rems, Lea, Kreutzer, Michiel T., Boukany, Pouyan E.

“…Transient physical disruption of cell membranes by electric pulses (or electroporation) has significance in biomedical and biological applications requiring…”
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Quantification of cell membrane permeability induced by monopolar and high-frequency bipolar bursts of electrical pulses by Sweeney, Daniel C., Reberšek, Matej, Dermol, Janja, Rems, Lea, Miklavčič, Damijan, Davalos, Rafael V.

“…High-frequency bipolar electric pulses have been shown to mitigate undesirable muscle contraction during irreversible electroporation (IRE) therapy. Here, we…”
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Identification of electroporation sites in the complex lipid organization of the plasma membrane by Rems, Lea, Tang, Xinru, Zhao, Fangwei, Pérez-Conesa, Sergio, Testa, Ilaria, Delemotte, Lucie

“…The plasma membrane of a biological cell is a complex assembly of lipids and membrane proteins, which tightly regulate transmembrane transport. When a cell is…”
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Response of an actin network in vesicles under electric pulses by Perrier, Dayinta L., Vahid, Afshin, Kathavi, Vaishnavi, Stam, Lotte, Rems, Lea, Mulla, Yuval, Muralidharan, Aswin, Koenderink, Gijsje H., Kreutzer, Michiel T., Boukany, Pouyan E.

“…We study the role of a biomimetic actin network during the application of electric pulses that induce electroporation or electropermeabilization, using giant…”
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Genetically engineered HEK cells as a valuable tool for studying electroporation in excitable cells by Batista Napotnik, Tina, Kos, Bor, Jarm, Tomaž, Miklavčič, Damijan, O’Connor, Rodney P., Rems, Lea

“…Electric pulses used in electroporation-based treatments have been shown to affect the excitability of muscle and neuronal cells. However, understanding the…”
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Flow of DNA in micro/nanofluidics: From fundamentals to applications by Rems, Lea, Kawale, Durgesh, Lee, L. James, Boukany, Pouyan E.

“…Thanks to direct observation and manipulation of DNA in micro/nanofluidic devices, we are now able to elucidate the relationship between the polymer…”
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The equivalence of different types of electric pulses for electrochemotherapy with cisplatin − an in vitro study by Scuderi, Maria, Dermol-Cerne, Janja, Scancar, Janez, Markovic, Stefan, Rems, Lea, Miklavcic, Damijan

“…Electrochemotherapy (ECT) is a treatment involving the administration of chemotherapeutics drugs followed by the application of 8 square monopolar pulses of…”
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Gene Electrotransfer into Mammalian Cells Using Commercial Cell Culture Inserts with Porous Substrate by Vindiš, Tina, Blažič, Anja, Khayyat, Diaa, Potočnik, Tjaša, Sachdev, Shaurya, Rems, Lea

“…Gene electrotransfer is one of the main non-viral methods for intracellular delivery of plasmid DNA, wherein pulsed electric fields are used to transiently…”
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Characterization of Experimentally Observed Complex Interplay between Pulse Duration, Electrical Field Strength, and Cell Orientation on Electroporation Outcome Using a Time-Dependent Nonlinear Numerical Model by Scuderi, Maria, Dermol-Černe, Janja, Batista Napotnik, Tina, Chaigne, Sebastien, Bernus, Olivier, Benoist, David, Sigg, Daniel C, Rems, Lea, Miklavčič, Damijan

“…Electroporation is a biophysical phenomenon involving an increase in cell membrane permeability to molecules after a high-pulsed electric field is applied to…”
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The molecular basis of electroporation of excitable cells by Rems, Lea, Batista Napotnik, Tina, Blazic, Anja, Kos, Bor

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Cellular excitability and ns-pulsed electric fields: Potential involvement of lipid oxidation in the action potential activation by Rems, Lea, Rainot, Aurianne, Wiczew, Daniel, Szulc, Natalia, Tarek, Mounir

“…•Lipid oxidation increases membrane capacitance and conductance.•Changes in membrane properties due to oxidation can trigger an action potential.•Potential…”
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Lipid vesicles in pulsed electric fields: Fundamental principles of the membrane response and its biomedical applications by Perrier, Dayinta L., Rems, Lea, Boukany, Pouyan E.

“…The present review focuses on the effects of pulsed electric fields on lipid vesicles ranging from giant unilamellar vesicles (GUVs) to small unilamellar…”
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Revisiting the role of pulsed electric fields in overcoming the barriers to in vivo gene electrotransfer by Sachdev, Shaurya, Potočnik, Tjaša, Rems, Lea, Miklavčič, Damijan

“…[Display omitted] Gene therapies are revolutionizing medicine by providing a way to cure hitherto incurable diseases. The scientific and technological advances…”
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Monitoring Electroporation-Induced Changes in Action Potential Generation in Genetically Engineered Tet-On Spiking HEK cells by Batista Napotnik, Tina, Kos, Bor, Rems, Lea

“…Excitable cells such as neuronal and muscle cells can be primary targets in rapidly emerging electroporation-based treatments. However, they can be affected by…”
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Molecular Dynamics of Cell Membrane Electroporation by Rems, Lea, Tang, Xinru, Zhao, Fangwei, Delemotte, Lucie

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The contribution of lipid peroxidation to membrane permeability in electropermeabilization: A molecular dynamics study by Rems, Lea, Viano, Marilyne, Kasimova, Marina A., Miklavčič, Damijan, Tarek, Mounir

“…Electroporation or electropermeabilization is a technique that enables transient increase in the cell membrane permeability by exposing cells to pulsed…”
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Models of electroporation and the associated transmembrane molecular transport should be revisited by Scuderi, Maria, Dermol-Černe, Janja, Amaral da Silva, Clarissa, Muralidharan, Aswin, Boukany, Pouyan E., Rems, Lea

“…•Critical assessment of models describing electroporation and molecular transport.•None of the models can be universily applied to the full range of…”
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Cell electrofusion using nanosecond electric pulses by Rems, Lea, Ušaj, Marko, Kandušer, Maša, Reberšek, Matej, Miklavčič, Damijan, Pucihar, Gorazd

“…Electrofusion is an efficient method for fusing cells using short-duration high-voltage electric pulses. However, electrofusion yields are very low when fusion…”
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