Search Results - "Remiszewski, Stacy W."

Psammaplins from the Sponge Pseudoceratina purpurea: Inhibition of Both Histone Deacetylase and DNA Methyltransferase by PIñA, Ivette C., GAUTSCHI, Jeffrey T., WANG, Gui-Yang-Sheng, SANDERS, Miranda L., SCHMITZ, Francis J., FRANCE, Dennis, CORNELL-KENNON, Susan, SAMBUCETTI, Lidia C., REMISZEWSKI, Stacy W., PEREZ, Larry B., BAIR, Kenneth W., CREWS, Phillip

“…Four novel bisulfide bromotyrosine derivatives, psammaplins E (9), F (10), G (11), and H (12), and two new bromotyrosine derivatives, psammaplins I (13) and J…”
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Inhibitors of Human Histone Deacetylase:  Synthesis and Enzyme and Cellular Activity of Straight Chain Hydroxamates by Remiszewski, Stacy W, Sambucetti, Lidia C, Atadja, Peter, Bair, Kenneth W, Cornell, Wendy D, Green, Michael A, Howell, Kobporn Lulu, Jung, Manfred, Kwon, Paul, Trogani, Nancy, Walker, Heather

“…Inhibitors of histone deacetylase (HDAC) have been shown to induce terminal differentiation of human tumor cell lines and to have antitumor effects in vivo. We…”
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Benzazepinones and Benzoxazepinones as Antagonists of Inhibitor of Apoptosis Proteins (IAPs) Selective for the Second Baculovirus IAP Repeat (BIR2) Domain by Donnell, Andrew F, Michoud, Christophe, Rupert, Kenneth C, Han, Xiaochun, Aguilar, Douglas, Frank, Karl B, Fretland, Adrian J, Gao, Lin, Goggin, Barry, Hogg, J. Heather, Hong, Kyoungja, Janson, Cheryl A, Kester, Robert F, Kong, Norman, Le, Kang, Li, Shirley, Liang, Weiling, Lombardo, Louis J, Lou, Yan, Lukacs, Christine M, Mischke, Steven, Moliterni, John A, Polonskaia, Ann, Schutt, Andrew D, Solis, Dave S, Specian, Anthony, Taylor, Robert T, Weisel, Martin, Remiszewski, Stacy W

“…XIAP is a key regulator of apoptosis, and its overexpression in cancer cells may contribute to their survival. The antiapoptotic function of XIAP derives from…”
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Optimization of Benzodiazepinones as Selective Inhibitors of the X‑Linked Inhibitor of Apoptosis Protein (XIAP) Second Baculovirus IAP Repeat (BIR2) Domain by Kester, Robert F, Donnell, Andrew F, Lou, Yan, Remiszewski, Stacy W, Lombardo, Louis J, Chen, Shaoqing, Le, Nam T, Lo, Jennifer, Moliterni, John A, Han, Xiaochun, Hogg, J. Heather, Liang, Weiling, Michoud, Christophe, Rupert, Kenneth C, Mischke, Steven, Le, Kang, Weisel, Martin, Janson, Cheryl A, Lukacs, Christine M, Fretland, Adrian J, Hong, Kyoungja, Polonskaia, Ann, Gao, Lin, Li, Shirley, Solis, Dave S, Aguilar, Doug, Tardell, Christine, Dvorozniak, Mark, Tannu, Shahid, Lee, Edmund C, Schutt, Andy D, Goggin, Barry

“…The IAPs are key regulators of the apoptotic pathways and are commonly overexpressed in many cancer cells. IAPs contain one to three BIR domains that are…”
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The discovery of NVP-LAQ824: from concept to clinic by Remiszewski, Stacy W

“…The natural products trapoxin B and trichostatin A, as well as the novel marine natural product psammaplin A (PSMA) were found in a cell-based screen for…”
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N-Hydroxy-3-phenyl-2-propenamides as Novel Inhibitors of Human Histone Deacetylase with in Vivo Antitumor Activity:  Discovery of (2E)-N-Hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824) by Remiszewski, Stacy W, Sambucetti, Lidia C, Bair, Kenneth W, Bontempo, John, Cesarz, David, Chandramouli, Nagarajan, Chen, Ru, Cheung, Min, Cornell-Kennon, Susan, Dean, Karl, Diamantidis, George, France, Dennis, Green, Michael A, Howell, Kobporn Lulu, Kashi, Rina, Kwon, Paul, Lassota, Peter, Martin, Mary S, Mou, Yin, Perez, Lawrence B, Sharma, Sushil, Smith, Troy, Sorensen, Eric, Taplin, Francis, Trogani, Nancy, Versace, Richard, Walker, Heather, Weltchek-Engler, Susan, Wood, Alexander, Wu, Arthur, Atadja, Peter

“…A series of N-hydroxy-3-phenyl-2-propenamides were prepared as novel inhibitors of human histone deacetylase (HDAC). These compounds were potent enzyme…”
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Psammaplins from the Sponge Pseudoceratina p urpurea: Inhibition of Both Histone Deacetylase and DNA Methyltransferase by Piña, Ivette C, Gautschi, Jeffrey T, Wang, Gui-Yang-Sheng, Sanders, Miranda L, Schmitz, Francis J, France, Dennis, Cornell-Kennon, Susan, Sambucetti, Lidia C, Remiszewski, Stacy W, Perez, Larry B, Bair, Kenneth W, Crews, Phillip

“…Four novel bisulfide bromotyrosine derivatives, psammaplins E (9), F (10), G (11), and H (12), and two new bromotyrosine derivatives, psammaplins I (13) and J…”
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Total synthesis of the latrunculins by Smith, Amos B, Leahy, James W, Noda, Ichio, Remiszewski, Stacy W, Liverton, Nigel J, Zibuck, Regina

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Recent advances in the discovery of small molecule histone deacetylase inhibitors by Remiszewski, Stacy W

“…The reversible acetylation of lysine amino groups in nuclear histones is an important mechanism by which gene expression is regulated, and may act by…”
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Synthesis of 5-epi-desosamine via a stereoselective intramolecular N-sulfinyl Diels-Alder cycloaddition by Remiszewski, Stacy W, Whittle, Robert R, Weinreb, Steven M

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N-hydroxy-3-phenyl-2-propenamides as novel inhibitors of human histone deacetylase with in vivo antitumor activity: Discovery of (2E)-N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]-phen yl]-2-propenamide (NVP-LAQ824) by REMISZEWSKI, Stacy W, SAMBUCETTI, Lidia C, DIAMANTIDIS, George, FRANCE, Dennis, GREEN, Michael A, HOWELL, Kobporn Lulu, KASHI, Rina, KWON, Paul, LASSOTA, Peter, MARTIN, Mary S, YIN MOU, PEREZ, Lawrence B, BAIR, Kenneth W, SHARMA, Sushil, SMITH, Troy, SORENSEN, Eric, TAPLIN, Francis, TROGANI, Nancy, VERSACE, Richard, WALKER, Heather, WELTCHEK-ENGLER, Susan, WOOD, Alexander, WU, Arthur, BONTEMPO, John, ATADJA, Peter, CESARZ, David, CHANDRAMOULI, Nagarajan, RU CHEN, MIN CHEUNG, CORNELL-KENNON, Susan, DEAN, Karl

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Total synthesis of (+)-latrunculin A by Smith, Amos B., Noda, Ichio, Remiszewski, Stacy W., Liverton, Nigel J., Zibuck, Regina

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