Search Results - "Remeta, David P."

Forces Driving a Magic Bullet to Its Target: Revisiting the Role of Thermodynamics in Drug Design, Development, and Optimization by Minetti, Conceição A, Remeta, David P

“…Drug discovery strategies have advanced significantly towards prioritizing target selectivity to achieve the longstanding goal of identifying "magic bullets"…”
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Mechanisms of antiviral action and toxicities of ipecac alkaloids: Emetine and dehydroemetine exhibit anti-coronaviral activities at non-cardiotoxic concentrations by Sidorenko, Viktoriya S., Cohen, Ira, Dorjee, Kunchok, Minetti, Conceição A., Remeta, David P., Gao, Junyuan, Potapova, Irina, Wang, Hong Zhan, Hearing, Janet, Yen, Wan-Yi, Kim, Hwan Keun, Hashimoto, Keiji, Moriya, Masaaki, Dickman, Kathleen G., Yin, Xingyu, Garcia-Diaz, Miguel, Chennamshetti, Rajesh, Bonala, Radha, Johnson, Francis, Waldeck, Amanda L., Gupta, Ramesh, Li, Chaoping, Breslauer, Kenneth J., Grollman, Arthur P., Rosenquist, Thomas A.

“…•Emetine and dehydroemetine inhibit both coronavirus growth and host-cell protein synthesis at nanomolar concentrations.•The stereochemical requirements of…”
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Structural Instability Tuning as a Regulatory Mechanism in Protein-Protein Interactions by Chen, Li, Balabanidou, Vassilia, Remeta, David P., Minetti, Conceição A.S.A., Portaliou, Athina G., Economou, Anastassios, Kalodimos, Charalampos G.

“…Protein-protein interactions mediate a vast number of cellular processes. Here, we present a regulatory mechanism in protein-protein interactions mediated by…”
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Characterization of Aurintricarboxylic Acid (ATA) Interactions with Plasma Transporter Protein and SARS-CoV-2 Viral Targets: Correlation of Functional Activity and Binding Energetics by Minetti, Conceição A., Remeta, David P., Hashimoto, Keiji, Bonala, Radha, Chennamshetti, Rajesh, Yin, Xingyu, Garcia-Diaz, Miguel, Grollman, Arthur P., Johnson, Francis, Sidorenko, Viktoriya S.

“…In an effort to identify functional-energetic correlations leading to the development of efficient anti-SARS-CoV-2 therapeutic agents, we have designed…”
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Substrate-Activated Conformational Switch on Chaperones Encodes a Targeting Signal in Type III Secretion by Chen, Li, Ai, Xuanjun, Portaliou, Athina G., Minetti, Conceicao A.S.A., Remeta, David P., Economou, Anastassios, Kalodimos, Charalampos G.

“…The targeting of type III secretion (TTS) proteins at the injectisome is an important process in bacterial virulence. Nevertheless, how the injectisome…”
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continuous hyperchromicity assay to characterize the kinetics and thermodynamics of DNA lesion recognition and base excision by Minetti, Conceição A.S.A, Remeta, David P, Breslauer, Kenneth J

“…We report a continuous hyperchromicity assay (CHA) for monitoring and characterizing enzyme activities associated with DNA processing. We use this assay to…”
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Substrate-Activated Conformational Switch on Chaperones Encodes a Targeting Signal in Type III Secretion by Chen, Li, Ai, Xuanjun, Portaliou, Athina G., Minetti, Conceicao A.S.A., Remeta, David P., Economou, Anastassios, Kalodimos, Charalampos G.

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Structural and mechanistic insights into the transport of aristolochic acids and their active metabolites by human serum albumin by Pomyalov, Sergei, Minetti, Conceição A., Remeta, David P., Bonala, Radha, Johnson, Francis, Zaitseva, Irina, Iden, Charles, Golebiewska, Urszula, Breslauer, Kenneth J., Shoham, Gil, Sidorenko, Viktoriya S., Grollman, Arthur P.

“…Aristolochic acids I and II (AA-I/II) are carcinogenic principles of Aristolochia plants, which have been employed in traditional medicinal practices and…”
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Magnesium Activates Microsecond Dynamics to Regulate Integrin-Collagen Recognition by Nunes, Ana Monica, Minetti, Conceição A.S.A., Remeta, David P., Baum, Jean

“…Integrin receptors bind collagen via metal-mediated interactions that are modulated by magnesium (Mg2+) levels in the extracellular matrix. Nuclear magnetic…”
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A Revised Picture of the Cu(II)−α-Synuclein Complex: The Role of N‑Terminal Acetylation by Moriarty, Gina M, Minetti, Conceição A. S. A, Remeta, David P, Baum, Jean

“…α-Synuclein (αS) is an amyloidogenic intrinsically disordered protein implicated in Parkinson’s disease, for which copper-mediated pathways of…”
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Massively parallel, computationally guided design of a proenzyme by Yachnin, Brahm J, Azouz, Laura R, White, 3rd, Ralph E, Minetti, Conceição A S A, Remeta, David P, Tan, Victor M, Drake, Justin M, Khare, Sagar D

“…Confining the activity of a designed protein to a specific microenvironment would have broad-ranging applications, such as enabling cell type-specific…”
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Impact of bistrand abasic sites and proximate orientation on DNA global structure and duplex energetics by Minetti, Conceição A., Sun, Jeffrey Y., Jacobs, Daniel P., Kang, Inkoo, Remeta, David P., Breslauer, Kenneth J.

“…Bistrand lesions embedded within a single helical turn of tridecameric deoxyoligonucleotide duplexes represent a model system for exploring the impact of…”
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Heat Shock Protein 90 kDa (Hsp90) Has a Second Functional Interaction Site with the Mitochondrial Import Receptor Tom70 by Zanphorlin, Leticia M., Lima, Tatiani B., Wong, Michael J., Balbuena, Tiago S., Minetti, Conceição A.S.A., Remeta, David P., Young, Jason C., Barbosa, Leandro R.S., Gozzo, Fabio C., Ramos, Carlos H.I.

“…To accomplish its crucial role, mitochondria require proteins that are produced in the cytosol, delivered by cytosolic Hsp90, and translocated to its interior…”
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The Thermodynamics of Template-Directed DNA Synthesis: Base Insertion and Extension Enthalpies by Conceição A. S. A. Minetti, Remeta, David P., Miller, Holly, Gelfand, Craig A., Plum, G. Eric, Grollman, Arthur P., Breslauer, Kenneth J.

“…We used stopped-flow calorimetry to measure the overall enthalpy change associated with template-directed nucleotide insertion and DNA extension. Specifically,…”
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HSF1, Aging, and Neurodegeneration by Liu, Alice Y, Minetti, Conceição A, Remeta, David P, Breslauer, Kenneth J, Chen, Kuang Yu

“…Heat shock factor 1 (HSF1) is a master transcription regulator that mediates the induction of heat shock protein chaperones for quality control (QC) of the…”
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What Drives Proteins into the Major or Minor Grooves of DNA? by Privalov, Peter L., Dragan, Anatoly I., Crane-Robinson, Colyn, Breslauer, Kenneth J., Remeta, David P., Minetti, Conceição A.S.A.

“…The energetic profiles of a significant number of protein–DNA systems at 20 °C reveal that, despite comparable Gibbs free energies, association with the major…”
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Acid-Induced Changes in Thermal Stability and Fusion Activity of Influenza Hemagglutinin by Remeta, David P, Krumbiegel, Mathias, Minetti, Conceição A. S. A, Puri, Anu, Ginsburg, Ann, Blumenthal, Robert

“…The conformational and thermal stability of full-length hemagglutinin (HA) of influenza virus (strain X31) has been investigated using a combination of…”
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Intrinsic local destabilization of the C-terminus predisposes integrin [alpha]1 I domain to a conformational switch induced by collagen binding by Nunes, Ana Monica, Zhu, Jie, Jezioro, Jacqueline, Minetti, Conceição ASA, Remeta, David P, Farndale, Richard W, Hamaia, Samir W, Baum, Jean

“…Integrin-collagen interactions play a critical role in a myriad of cellular functions that include immune response, and cell development and differentiation,…”
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Intrinsic local destabilization of the C‐terminus predisposes integrin α1 I domain to a conformational switch induced by collagen binding by Nunes, Ana Monica, Zhu, Jie, Jezioro, Jacqueline, Minetti, Conceição A.S.A., Remeta, David P., Farndale, Richard W., Hamaia, Samir W., Baum, Jean

“…Integrin–collagen interactions play a critical role in a myriad of cellular functions that include immune response, and cell development and differentiation,…”
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Impact of thymine glycol damage on DNA duplex energetics: Correlations with lesion-induced biochemical and structural consequences by Minetti, Conceição A. S. A., Remeta, David P., Iden, Charles R., Johnson, Francis, Grollman, Arthur P., Breslauer, Kenneth J.

“…ABSTRACT The magnitude and nature of lesion‐induced energetic perturbations empirically correlate with mutagenicity/cytotoxicity profiles and can be predictive…”
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