Search Results - "Reme, CE"

Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration by Wenzel, Andreas, Grimm, Christian, Samardzija, Marijana, Remé, Charlotte E.

“…Human retinal dystrophies and degenerations and light-induced retinal degenerations in animal models are sharing an important feature: visual cell death by…”
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Cooperative Phagocytes: Resident Microglia and Bone Marrow Immigrants Remove Dead Photoreceptors in Retinal Lesions by Joly, Sandrine, Francke, Mike, Ulbricht, Elke, Beck, Susanne, Seeliger, Matthias, Hirrlinger, Petra, Hirrlinger, Johannes, Lang, Karl S, Zinkernagel, Martin, Odermatt, Bernhard, Samardzija, Marijana, Reichenbach, Andreas, Grimm, Christian, Reme, Charlotte E

“…Phagocytosis is essential for the removal of photoreceptor debris following retinal injury. We used two mouse models, mice injected with green fluorescent…”
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HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration by Grimm, Christian, Wenzel, Andreas, Groszer, Matthias, Mayser, Helmut, Seeliger, Mathias, Samardzija, Marijana, Bauer, Christian, Gassmann, Max, Remé, Charlotte E

“…Erythropoietin (Epo) is upregulated by hypoxia and provides protection against apoptosis of erythroid progenitors in bone marrow and brain neurons. Here we…”
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The Rpe65 Leu450Met variation increases retinal resistance against light-induced degeneration by slowing rhodopsin regeneration by Wenzel, A, Reme, C E, Williams, T P, Hafezi, F, Grimm, C

“…Excessive light can cause retinal degeneration and may be an environmental cofactor accelerating retinal dystrophies and age-related diseases. In rodent…”
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Evidence for two apoptotic pathways in light-induced retinal degeneration by Wenzel, Andreas, Taylor, Allen, Chen, Ching-Kang, Remé, Charlotte E, Brill, Elliott, Hao, Wenshan, Obin, Martin S, Lem, Janis, Krasnoperova, Nataliia V, Grimm, Christian, Kleyner, Yelena, Simon, Melvin I, Eversole-Cire, Pamela

“…Excessive phototransduction signaling is thought to be involved in light-induced and inherited retinal degeneration. Using knockout mice with defects in…”
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Protection of Rpe65 -deficient mice identifies rhodopsin as a mediator of light-induced retinal degeneration by Redmond, T. Michael, Remé, Charlotte E, Hafezi, Farhad, Yu, Shirley, Wenzel, Andreas, Grimm, Christian

“…Light-induced apoptosis of photoreceptors represents an animal model for retinal degeneration. Major human diseases that affect vision, such as age-related…”
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Rpe65 as a modifier gene for inherited retinal degeneration by Samardzija, M., Wenzel, A., Naash, M., Remé, C. E., Grimm, C.

“…Light accelerates progression of retinal degeneration in many animal models of retinitis pigmentosa (RP). A sequence variant in the Rpe65 gene (Rpe65450Leu or…”
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Rhodopsin-Mediated Blue-Light Damage to the Rat Retina: Effect of Photoreversal of Bleaching by Grimm, Christian, Wenzel, Andreas, Williams, Theodore P, Rol, Pascal O, Hafezi, Farhad, Reme, Charlotte E

“…Acute white-light damage to rods depends on the amount of rhodopsin available for bleaching during light exposure. Bleached rhodopsin is metabolically…”
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New views on RPE65 deficiency: the rod system is the source of vision in a mouse model of Leber congenital amaurosis by Redmond, T. Michael, Zrenner, Eberhart, Wenzel, Andreas, Remé, Charlotte E, Jaissle, Gesine, Biel, Martin, Fariss, Robert N, Humphries, Peter, Ståhlberg, Fredrik, Grimm, Christian, Seeliger, Mathias W, Hofmann, Franz, Friedburg, Christoph, Guo, Hao

“…Leber congenital amaurosis (LCA) is the most serious form of the autosomal recessive childhood-onset retinal dystrophies. Mutations in the gene encoding RPE65,…”
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The genetic modifier Rpe65Leu(450): effect on light damage susceptibility in c-Fos-deficient mice by Wenzel, Andreas, Grimm, Christian, Samardzija, Marijana, Remé, Charlotte E

“…To test whether introduction of the Rpe65Leu(450) variant can overcome protection against light-induced photoreceptor apoptosis in mice without the activator…”
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The Retinal G Protein-coupled Receptor (RGR) Enhances Isomerohydrolase Activity Independent of Light by Wenzel, Andreas, Oberhauser, Vitus, Pugh, Jr, Edward N, Lamb, Trevor D, Grimm, Christian, Samardzija, Marijana, Fahl, Edda, Seeliger, Mathias W, Remé, Charlotte E, von Lintig, Johannes

“…Rod and cone visual pigments use 11- cis- retinal, a vitamin A derivative, as their chromophore. Light isomerizes 11- cis- into all- trans- retinal, triggering…”
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Apoptotic cell death in retinal degenerations by Remé, Charlotte E, Grimm, Christian, Hafezi, Farhad, Marti, Andreas, Wenzel, Andreas

“…Apoptosis is a regulated mode of single cell death that involves gene expression in many instances and occurs under physiological and pathological conditions…”
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c-fos Controls the "Private Pathway" of Light-Induced Apoptosis of Retinal Photoreceptors by Wenzel, Andreas, Grimm, Christian, Marti, Andreas, Kueng-Hitz, Nicole, Hafezi, Farhad, Niemeyer, Gunter, Reme, Charlotte E

“…White light (5 klux for 2 hr) induces apoptosis of rod photoreceptors in wild-type mice (c-fos(+/+)) within 24 hr, whereas rods of c-fos knock-out mice…”
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Fra-1 replaces c-Fos-dependent functions in mice by Fleischmann, A, Hafezi, F, Elliott, C, Remé, C E, Rüther, U, Wagner, E F

“…Structure-function analysis as well as studies with knock-out and transgenic mice have assigned distinct functions to c-Fos and Fra-1, two components of the…”
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Gene expression in the mouse retina: the effect of damaging light by Grimm, C, Wenzel, A, Hafezi, F, Remé, C E

“…High levels of visible light induce apoptotic cell death of photoreceptors, a process depending on the activation of the transcription factor AP-1. This…”
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Prevention of Photoreceptor Apoptosis by Activation of the Glucocorticoid Receptor by Wenzel, Andreas, Grimm, Christian, Seeliger, Mathias W, Jaissle, Gesine, Hafezi, Farhad, Kretschmer, Robert, Zrenner, Eberhart, Reme, Charlotte E

“…Evidence has accumulated that excessive light exposure may promote age-related and inherited retinal degeneration, in which photoreceptor death by apoptosis…”
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The absence of c-fos prevents light-induced apoptotic cell death of photoreceptors in retinal degeneration in vivo by Hafezi, Farhad, Steinbach, Joachim P, Marti, Andreas, Munz, Kurt, Wang, Zhao-Qi, Wagner, Erwin F, Aguzzi, Adriano, Remé, Charlotte E

“…Apoptotic cell death in the retina was recently demonstrated in animal models of the hereditary human retinal dystrophy known as retinitis pigmentosa. Although…”
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Protective Effect of Halothane Anesthesia on Retinal Light Damage: Inhibition of Metabolic Rhodopsin Regeneration by Keller, Charlotte, Grimm, Christian, Wenzel, Andreas, Hafezi, Farhad, Reme, Charlotte E

“…To determine whether the volatile anesthetic halothane protects against light-induced photoreceptor degeneration in the rodent retina. Albino mice and rats…”
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Blue Light's Effects on Rhodopsin: Photoreversal of Bleaching in Living Rat Eyes by Grimm, Christian, Reme, Charlotte E, Rol, Pascal O, Williams, Theodore P

“…To determine whether blue light induces photoreversal of rhodopsin bleaching in vivo. Eyes of anesthetized albino rats were exposed to either green (550 nm) or…”
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Light-induced Apoptosis: Differential Timing in the Retina and Pigment Epithelium by HAFEZI, FARHAD, MARTI, ANDREAS, MUNZ, KURT, REMÉ, CHARLOTTE E

“…Apoptosis is a genetically regulated form of cell death. Individual cells show condensed nuclear chromatin and cytoplasm, and biochemical analysis reveals…”
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